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MX2022002747A - Proteinas de fusion de ca2-il15 para regulacion ajustable. - Google Patents

Proteinas de fusion de ca2-il15 para regulacion ajustable.

Info

Publication number
MX2022002747A
MX2022002747A MX2022002747A MX2022002747A MX2022002747A MX 2022002747 A MX2022002747 A MX 2022002747A MX 2022002747 A MX2022002747 A MX 2022002747A MX 2022002747 A MX2022002747 A MX 2022002747A MX 2022002747 A MX2022002747 A MX 2022002747A
Authority
MX
Mexico
Prior art keywords
fusion proteins
adjustable regulation
regulation
adjustable
human
Prior art date
Application number
MX2022002747A
Other languages
English (en)
Inventor
Celeste Richardson
Jennifer Leah Gori
Vipin Suri
Kutlu Goksu Elpek
Scott Francis Heller
Dexue Sun
Meghan C Langley
Tucker Read Ezell
Geetha Hanna Mylvaganam
Michelle Ols
Michelle Fleury
James A Storer
Shyamsundar Subramanian
Colleen Foley
Molly Reed Perkins
Jeremy Hatem Tchaicha
Dhruv Kam Sethi
Original Assignee
Obsidian Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Obsidian Therapeutics Inc filed Critical Obsidian Therapeutics Inc
Publication of MX2022002747A publication Critical patent/MX2022002747A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
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    • C12Y402/01—Hydro-lyases (4.2.1)
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
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    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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Abstract

La presente descripción proporciona dominios sensibles & fármaco derivados de la anhidrasa carbónica humana 2 que puede modular la estabilidad de proteínas para cargas útiles de interleucina humana 15 (IL15), así como composiciones y métodos de uso de los mismos.
MX2022002747A 2019-09-10 2020-09-10 Proteinas de fusion de ca2-il15 para regulacion ajustable. MX2022002747A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962898520P 2019-09-10 2019-09-10
PCT/US2020/050273 WO2021050789A1 (en) 2019-09-10 2020-09-10 Ca2-il15 fusion proteins for tunable regulation

Publications (1)

Publication Number Publication Date
MX2022002747A true MX2022002747A (es) 2022-04-06

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MX2022002747A MX2022002747A (es) 2019-09-10 2020-09-10 Proteinas de fusion de ca2-il15 para regulacion ajustable.

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US (2) US11058725B2 (es)
EP (1) EP4028413A1 (es)
JP (2) JP7692897B2 (es)
CN (1) CN114651003A (es)
CA (1) CA3150224A1 (es)
MX (1) MX2022002747A (es)
WO (1) WO2021050789A1 (es)

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BR112021025022A2 (pt) * 2019-06-12 2022-02-22 Obsidian Therapeutics Inc Composições de ca2 e métodos para regulação ajustáveis
WO2022060806A1 (en) * 2020-09-16 2022-03-24 Obsidian Therapeutics, Inc. Compositions and methods for expression of anti-bcma chimeric antigen receptors with small molecule-regulated il15 in t cells
JP2024504585A (ja) 2021-01-19 2024-02-01 オブシディアン セラピューティクス， インコーポレイテッド Ｔ細胞及び腫瘍浸潤リンパ球の拡張のための組成物及び方法
CA3206549A1 (en) * 2021-01-29 2022-08-04 Frederick G. Vogt Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy
WO2023010090A1 (en) * 2021-07-29 2023-02-02 Sqz Biotechnologies Company Methods to generate enhanced tumor infiltrating lymphocytes through microfluidic delivery
MX2024004777A (es) 2021-10-18 2024-07-10 Obsidian Therapeutics Inc Composiciones y sistemas para la regulacion de la funcion/abundancia y la administracion de cargas utiles de polipeptidos.
JP2024545582A (ja) * 2021-11-11 2024-12-10 ステムセル テクノロジーズ カナダ インコーポレイテッド マイクロ流体送達による増強された腫瘍浸潤リンパ球を作製する方法
EP4466010A1 (en) 2022-01-18 2024-11-27 Obsidian Therapeutics, Inc. Methods for identifying and using allogeneic tumor infiltrating lymphocytes to treat cancer
WO2024186735A1 (en) * 2023-03-03 2024-09-12 Memorial Sloan-Kettering Cancer Center Methods and compositions for the treatment of cancer
WO2025122943A1 (en) 2023-12-08 2025-06-12 Obsidian Therapeutics, Inc. Compositions and methods for enhanced payload regulation using nuclear factor of activated t cells (nfat) response elements
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