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MX2022001407A - Compuestos derivados y relacionados de bis-[n-((5-carbamoil)-1h be nzo[d]imidazol-2-yl)-pyrazol-5-carboxamida] como agonistas de sting (estimulador de genes de interferón) para el tratamiento de cáncer. - Google Patents

Compuestos derivados y relacionados de bis-[n-((5-carbamoil)-1h be nzo[d]imidazol-2-yl)-pyrazol-5-carboxamida] como agonistas de sting (estimulador de genes de interferón) para el tratamiento de cáncer.

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Publication number
MX2022001407A
MX2022001407A MX2022001407A MX2022001407A MX2022001407A MX 2022001407 A MX2022001407 A MX 2022001407A MX 2022001407 A MX2022001407 A MX 2022001407A MX 2022001407 A MX2022001407 A MX 2022001407A MX 2022001407 A MX2022001407 A MX 2022001407A
Authority
MX
Mexico
Prior art keywords
imidazol
sting
carboxamide
agonists
cancer
Prior art date
Application number
MX2022001407A
Other languages
English (en)
Inventor
Joshua D Thomas
Dorin Toader
Jeremy R Duvall
Keith W Bentley
Brian D Jones
Eugene W Kelleher
Soumya S Ray
Original Assignee
Mersana Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mersana Therapeutics Inc filed Critical Mersana Therapeutics Inc
Publication of MX2022001407A publication Critical patent/MX2022001407A/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

La presente invención se refiere a compuestos de fórmula (IA') como agonistas de STING (estimulador de genes de interferón) para usarse en el tratamiento de, por ejemplo, cáncer, obesidad, lesiones hepáticas, metabolismo de lípidos y glucosa y infecciones virales. La presente invensión divulga la sintésis y caracterización de compuentos ejemplares, así como de los datos farmacológicos de los mismos (por ejemplo, páginas 128 a 286: ejemplos 1 a 54; tablas 1, 2a, 2b y 3). Un compuesto ejemplar es, por ejemplo, ejemplo 1: (E)-N-(5-carbamoil-1-(4-(5-carbamoil-2-(4- etil-2-metiloxazol-5-carboxamido)-7- (3-hidroxipropoxi)-1H-benzo[d ]imidazol-1-il)but-2-en-1-il)-7-metoxi-1H-benzo[d]imidazol-2-il)- 4-etil-2- metiloxazol-5-carboxamida (compuesto 9).
MX2022001407A 2019-08-02 2020-07-31 Compuestos derivados y relacionados de bis-[n-((5-carbamoil)-1h be nzo[d]imidazol-2-yl)-pyrazol-5-carboxamida] como agonistas de sting (estimulador de genes de interferón) para el tratamiento de cáncer. MX2022001407A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962882081P 2019-08-02 2019-08-02
US201962944643P 2019-12-06 2019-12-06
US202062982935P 2020-02-28 2020-02-28
PCT/US2020/044538 WO2021026009A1 (en) 2019-08-02 2020-07-31 Bis-[n-((5-carbamoyl)-1h-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as sting (stimulator of interferon genes) agonists for the treatment of cancer

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MX2022001407A true MX2022001407A (es) 2022-04-27

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MX2022001407A MX2022001407A (es) 2019-08-02 2020-07-31 Compuestos derivados y relacionados de bis-[n-((5-carbamoil)-1h be nzo[d]imidazol-2-yl)-pyrazol-5-carboxamida] como agonistas de sting (estimulador de genes de interferón) para el tratamiento de cáncer.
MX2025006327A MX2025006327A (es) 2019-08-02 2022-02-01 Compuestos derivados y relacionados de bis-[n-((5- carbamoil)-1hbenzo[d]imidazol-2-yl)-pyrazol-5- carboxamida] como agonistas de sting (estimulador de genes de interferón) para el tratamiento de cáncer.

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US (3) US11155567B2 (es)
EP (1) EP4007758A1 (es)
JP (1) JP2022543086A (es)
KR (1) KR20220056176A (es)
CN (1) CN114585623A (es)
AU (1) AU2020324388A1 (es)
BR (1) BR112022001931A2 (es)
CA (1) CA3149482A1 (es)
IL (1) IL290212A (es)
MX (2) MX2022001407A (es)
TW (1) TW202120500A (es)
WO (1) WO2021026009A1 (es)
ZA (1) ZA202201505B (es)

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JP7664680B2 (ja) 2017-03-29 2025-04-18 リガケム バイオサイエンシズ， インク． ピロロベンゾジアゼピン二量体前駆体及びそのリガンド－リンカーコンジュゲート化合物
AU2020214477B2 (en) * 2019-01-31 2022-10-27 Hitgen Inc. Immunomodulator
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JP2022543086A (ja) 2019-08-02 2022-10-07 メルサナ セラピューティクス インコーポレイテッド がんの処置用のＳＴＩＮＧ（インターフェロン遺伝子刺激因子）アゴニストとしてのビス－［Ｎ－（（５－カルバモイル）－１Ｈ－ベンゾ［ｄ］イミダゾール－２－イル）－ピラゾール－５－カルボキサミド］誘導体および関連化合物
JP2023520513A (ja) * 2020-04-02 2023-05-17 メルサナ セラピューティクス インコーポレイテッド Ｓｔｉｎｇアゴニストを含む抗体薬物コンジュゲート
WO2021206158A1 (ja) 2020-04-10 2021-10-14 小野薬品工業株式会社 がん治療方法
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