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MX2022001292A - Composiciones enriquecidas estereoquimicamente para administracion de acidos nucleicos. - Google Patents

Composiciones enriquecidas estereoquimicamente para administracion de acidos nucleicos.

Info

Publication number
MX2022001292A
MX2022001292A MX2022001292A MX2022001292A MX2022001292A MX 2022001292 A MX2022001292 A MX 2022001292A MX 2022001292 A MX2022001292 A MX 2022001292A MX 2022001292 A MX2022001292 A MX 2022001292A MX 2022001292 A MX2022001292 A MX 2022001292A
Authority
MX
Mexico
Prior art keywords
formula
delivery
chemical entities
nucleic acids
enriched compositions
Prior art date
Application number
MX2022001292A
Other languages
English (en)
Inventor
Shrirang Karve
Frank Derosa
Michael Heartlein
Original Assignee
Shire Human Genetic Therapies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Human Genetic Therapies filed Critical Shire Human Genetic Therapies
Publication of MX2022001292A publication Critical patent/MX2022001292A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Se proporciona, en parte, una composición que comprende una o más entidades químicas de fórmula I, cada una de las cuales es un compuesto de fórmula (I): una sal farmacéuticamente aceptable de éste, un solvato de éste, o un solvato de una sal farmacéuticamente aceptable de éste, la composición se caracteriza porque más de una primera cantidad umbral de la cantidad total de entidades químicas de fórmula I en la composición: son entidades químicas de fórmula I.a, en donde la primera cantidad umbral es 50 %; o son entidades químicas de fórmula I.b.1, en donde la primera cantidad umbral es 25 %; o son entidades químicas de fórmula I.b.2, en donde la primera cantidad umbral es 25 %, en donde las entidades químicas de fórmula I.a, I.b.1 y I.b.2 se describen en la presente, y métodos para utilizar dichas composiciones, por ejemplo, para la administración de un polinucleótido in vivo.
MX2022001292A 2014-06-24 2017-01-04 Composiciones enriquecidas estereoquimicamente para administracion de acidos nucleicos. MX2022001292A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462016512P 2014-06-24 2014-06-24

Publications (1)

Publication Number Publication Date
MX2022001292A true MX2022001292A (es) 2022-02-22

Family

ID=54929772

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2017000143A MX389802B (es) 2014-06-24 2015-06-24 Composiciones enriquecidas estereoquimicamente para administracion de acidos nucleicos.
MX2022001292A MX2022001292A (es) 2014-06-24 2017-01-04 Composiciones enriquecidas estereoquimicamente para administracion de acidos nucleicos.
MX2022001291A MX2022001291A (es) 2014-06-24 2017-01-04 Composiciones enriquecidas estereoquimicamente para administracion de acidos nucleicos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017000143A MX389802B (es) 2014-06-24 2015-06-24 Composiciones enriquecidas estereoquimicamente para administracion de acidos nucleicos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022001291A MX2022001291A (es) 2014-06-24 2017-01-04 Composiciones enriquecidas estereoquimicamente para administracion de acidos nucleicos.

Country Status (17)

Country Link
US (4) US10138213B2 (es)
EP (1) EP3160959B1 (es)
JP (1) JP6599373B2 (es)
KR (3) KR102387898B1 (es)
CN (3) CN116059170A (es)
AU (4) AU2015279968B2 (es)
CA (1) CA2952824C (es)
CL (1) CL2016003263A1 (es)
EA (1) EA033966B1 (es)
ES (1) ES2964588T3 (es)
IL (1) IL249615A0 (es)
MA (1) MA40241A (es)
MX (3) MX389802B (es)
PE (1) PE20171238A1 (es)
SG (1) SG11201610670WA (es)
UA (1) UA121863C2 (es)
WO (1) WO2015200465A1 (es)

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WO2018144709A2 (en) * 2017-02-01 2018-08-09 The Trustees Of The University Of Pennsylvania Gene therapy for treating citrullenemia
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AU2019271132B2 (en) * 2018-05-15 2026-02-05 Translate Bio, Inc. Subcutaneous delivery of messenger RNA
KR20210060480A (ko) 2018-08-24 2021-05-26 트랜슬레이트 바이오 인코포레이티드 전령 rna의 정제 방법
KR20210093232A (ko) 2018-10-09 2021-07-27 더 유니버시티 오브 브리티시 콜롬비아 유기용매와 세제가 없는 형질감염 적격 소포를 포함하는 조성물과 시스템 및 관련 방법
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EP4076647A1 (en) 2019-12-20 2022-10-26 CureVac AG Lipid nanoparticles for delivery of nucleic acids
CN111658782A (zh) * 2020-06-10 2020-09-15 深圳近邻生物科技有限公司 mRNA疫苗递送载体及制备方法、mRNA疫苗及制备方法
MX2023003344A (es) * 2020-09-23 2023-06-05 Translate Bio Inc Lipidos cationicos a base de piperazina.
US12458604B2 (en) 2020-10-14 2025-11-04 The Trustees Of The University Of Pennsylvania Methods of lipid nanoparticle manufacture and compositions derived therefrom
WO2022099003A1 (en) 2020-11-06 2022-05-12 Sanofi Lipid nanoparticles for delivering mrna vaccines
CA3230031A1 (en) 2021-09-03 2023-03-09 Patrick Baumhof Novel lipid nanoparticles for delivery of nucleic acids
US20250027108A1 (en) 2021-10-29 2025-01-23 CureVac SE Improved circular rna for expressing therapeutic proteins
EP4469091A1 (en) 2022-01-28 2024-12-04 CureVac SE Nucleic acid encoded transcription factor inhibitors
JP2025517508A (ja) 2022-05-25 2025-06-05 キュアバック エスイー 核酸ベースのワクチン
DE202023106198U1 (de) 2022-10-28 2024-03-21 CureVac SE Impfstoff auf Nukleinsäurebasis
DE112024001143T5 (de) 2023-03-08 2025-12-18 CureVac SE Neue lipid-nanopartikel-formeln für die abgabe von nukleinsäuren
WO2024230934A1 (en) 2023-05-11 2024-11-14 CureVac SE Therapeutic nucleic acid for the treatment of ophthalmic diseases

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