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MX2021009744A - Composiciones de anticuerpos lym-1 y lym-2 y constructos car mejorados. - Google Patents

Composiciones de anticuerpos lym-1 y lym-2 y constructos car mejorados.

Info

Publication number
MX2021009744A
MX2021009744A MX2021009744A MX2021009744A MX2021009744A MX 2021009744 A MX2021009744 A MX 2021009744A MX 2021009744 A MX2021009744 A MX 2021009744A MX 2021009744 A MX2021009744 A MX 2021009744A MX 2021009744 A MX2021009744 A MX 2021009744A
Authority
MX
Mexico
Prior art keywords
lym
antibodies
compositions
car constructs
improved car
Prior art date
Application number
MX2021009744A
Other languages
English (en)
Inventor
Alan L Epstein
Peisheng Hu
Long Zheng
Original Assignee
Univ Southern California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Southern California filed Critical Univ Southern California
Publication of MX2021009744A publication Critical patent/MX2021009744A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C12N5/0634—Cells from the blood or the immune system
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    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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Abstract

Se proporcionan en la presente anticuerpos novedosos y células receptoras de antígeno quimérico (CAR) que comprenden los dominios de unión a antígeno de estos anticuerpos. También se proporcionan composiciones que comprenden los mismos, el vector o el plásmido que codifica los anticuerpos y CARs, y métodos para producir los mismos o utilizar los mismos para detectar o tratar cáncer y kits para llevar a cabo los métodos.
MX2021009744A 2019-02-15 2020-02-14 Composiciones de anticuerpos lym-1 y lym-2 y constructos car mejorados. MX2021009744A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962806632P 2019-02-15 2019-02-15
US201962815961P 2019-03-08 2019-03-08
US201962924151P 2019-10-21 2019-10-21
PCT/US2020/018441 WO2020168298A2 (en) 2019-02-15 2020-02-14 Lym-1 and lym-2 antibody compositions and improved car constructs

Publications (1)

Publication Number Publication Date
MX2021009744A true MX2021009744A (es) 2021-11-12

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MX2021009744A MX2021009744A (es) 2019-02-15 2020-02-14 Composiciones de anticuerpos lym-1 y lym-2 y constructos car mejorados.

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US (2) US11667715B2 (es)
EP (1) EP3924387A4 (es)
JP (1) JP2022520106A (es)
KR (1) KR20210118945A (es)
CN (1) CN113710703A (es)
AU (1) AU2020221324A1 (es)
BR (1) BR112021015676A2 (es)
CA (1) CA3129501A1 (es)
IL (1) IL285463A (es)
MX (1) MX2021009744A (es)
SG (1) SG11202108655TA (es)
WO (1) WO2020168298A2 (es)

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GB201913697D0 (en) * 2019-09-23 2019-11-06 King S College London DAP10/DAP12 fusion polypeptides

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