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MX2021008663A - Anticuerpos mejorados contra il-6. - Google Patents

Anticuerpos mejorados contra il-6.

Info

Publication number
MX2021008663A
MX2021008663A MX2021008663A MX2021008663A MX2021008663A MX 2021008663 A MX2021008663 A MX 2021008663A MX 2021008663 A MX2021008663 A MX 2021008663A MX 2021008663 A MX2021008663 A MX 2021008663A MX 2021008663 A MX2021008663 A MX 2021008663A
Authority
MX
Mexico
Prior art keywords
antibodies against
enhanced antibodies
enhanced
antibodies
treatment
Prior art date
Application number
MX2021008663A
Other languages
English (en)
Inventor
Alison Tisdale
Michael March Schmidt
Grigorios Zarbis-Papastoitsis
Eric Steven Furfine
Original Assignee
Eleven Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eleven Biotherapeutics Inc filed Critical Eleven Biotherapeutics Inc
Publication of MX2021008663A publication Critical patent/MX2021008663A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se proporcionan anticuerpos contra IL-6 mejorados. Se describen los usos de los anticuerpos en el tratamiento de enfermedades relacionadas a IL-6, por ejemplo, enfermedades oculares tales como edema macular diabético.
MX2021008663A 2014-11-07 2017-05-08 Anticuerpos mejorados contra il-6. MX2021008663A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462077105P 2014-11-07 2014-11-07
US201462087448P 2014-12-04 2014-12-04
US201562247705P 2015-10-28 2015-10-28

Publications (1)

Publication Number Publication Date
MX2021008663A true MX2021008663A (es) 2021-08-19

Family

ID=54602042

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017005992A MX385206B (es) 2014-11-07 2015-11-06 Anticuerpos mejorados contra il-6.
MX2021008663A MX2021008663A (es) 2014-11-07 2017-05-08 Anticuerpos mejorados contra il-6.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017005992A MX385206B (es) 2014-11-07 2015-11-06 Anticuerpos mejorados contra il-6.

Country Status (33)

Country Link
US (3) US11142571B2 (es)
EP (3) EP3215530B9 (es)
JP (1) JP6594438B2 (es)
KR (2) KR102636726B1 (es)
CN (1) CN107249631B (es)
AU (1) AU2015342882B2 (es)
CA (1) CA2965689C (es)
CL (1) CL2017001135A1 (es)
CO (1) CO2017005404A2 (es)
CR (1) CR20170231A (es)
DK (2) DK4268843T3 (es)
EA (1) EA035199B1 (es)
ES (2) ES2756275T3 (es)
FI (1) FI4268843T3 (es)
HR (2) HRP20191945T1 (es)
HU (1) HUE046181T2 (es)
IL (1) IL251858B (es)
LT (1) LT4268843T (es)
MA (2) MA62787B1 (es)
MX (2) MX385206B (es)
MY (1) MY185114A (es)
PE (1) PE20171107A1 (es)
PH (1) PH12017500809B1 (es)
PL (2) PL4268843T3 (es)
PT (2) PT3215530T (es)
RS (2) RS67353B1 (es)
SA (1) SA517381458B1 (es)
SG (2) SG11201703574VA (es)
SI (2) SI3215530T1 (es)
SM (1) SMT202500415T1 (es)
UA (1) UA122673C2 (es)
WO (1) WO2016073890A1 (es)
ZA (1) ZA201702985B (es)

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CN110891611B (zh) 2017-03-22 2024-03-29 阿森迪斯制药公司 水凝胶交联透明质酸前药组合物和方法
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JP7767298B2 (ja) 2020-03-13 2025-11-11 ジェネンテック， インコーポレイテッド 抗インターロイキン－３３抗体及びその使用
MX2022011752A (es) 2020-03-24 2022-10-18 Genentech Inc Agentes de fijacion a tie2 y metodos de uso.
CA3198668A1 (en) 2020-10-15 2022-04-21 Genentech, Inc. Hyaluronic acid binding derivatives of versican (vg1) for long acting delivery of therapeutics
CN114525235B (zh) * 2022-02-25 2023-07-14 郑州大学 一种提高人表皮生长因子分泌生产效率的方法
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Also Published As

Publication number Publication date
US20250059270A1 (en) 2025-02-20
FI4268843T3 (fi) 2025-11-14
KR20170077196A (ko) 2017-07-05
BR112017008672A2 (pt) 2018-03-20
MA51554A (fr) 2020-11-18
RS59805B1 (sr) 2020-02-28
CR20170231A (es) 2017-09-25
KR102636726B1 (ko) 2024-02-13
SI3215530T1 (sl) 2020-02-28
EP3215530B1 (en) 2019-08-21
PL4268843T3 (pl) 2025-12-15
ZA201702985B (en) 2019-10-30
MX2017005992A (es) 2017-09-15
PH12017500809B1 (en) 2023-09-20
IL251858A0 (en) 2017-06-29
CL2017001135A1 (es) 2017-12-15
ES3051832T3 (en) 2025-12-30
JP2017535285A (ja) 2017-11-30
CO2017005404A2 (es) 2017-10-31
HUE046181T2 (hu) 2020-02-28
PE20171107A1 (es) 2017-08-07
CA2965689A1 (en) 2016-05-12
EA201791005A1 (ru) 2017-09-29
PL3215530T3 (pl) 2020-05-18
US20220169719A1 (en) 2022-06-02
PT3215530T (pt) 2019-11-21
AU2015342882B2 (en) 2021-05-20
CA2965689C (en) 2022-03-22
AU2015342882A1 (en) 2017-05-18
MA62787B1 (fr) 2025-11-28
CN107249631B (zh) 2021-11-23
SG10202103420PA (en) 2021-05-28
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