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MX2021002854A - Ciclacion enzimatica de acido homofarnesilico. - Google Patents

Ciclacion enzimatica de acido homofarnesilico.

Info

Publication number
MX2021002854A
MX2021002854A MX2021002854A MX2021002854A MX2021002854A MX 2021002854 A MX2021002854 A MX 2021002854A MX 2021002854 A MX2021002854 A MX 2021002854A MX 2021002854 A MX2021002854 A MX 2021002854A MX 2021002854 A MX2021002854 A MX 2021002854A
Authority
MX
Mexico
Prior art keywords
homofarnesylic acid
homofarnesylic
enzymatic cyclization
acid
cyclization
Prior art date
Application number
MX2021002854A
Other languages
English (en)
Inventor
Stefan Rüdenauer
Michael Breuer
Wolfgang Siegel
Ralf Pelzer
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of MX2021002854A publication Critical patent/MX2021002854A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01129—Squalene--hopanol cyclase (4.2.1.129)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
    • C12Y504/99017—Squalene--hopene cyclase (5.4.99.17)

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a procesos para la sintetización de esclareolida y compuestos relacionados por ciclación biocatalítica de compuestos de ácido carboxílico poliinsaturado, en particular de ácido homofarnesílico y compuestos relacionados. La invención también se refiere a un proceso para la sintetización de ambróxido por medio de ciclación biocatalítica de ácido homofarnesílico por medio de la cual se obtiene esclareolida.
MX2021002854A 2016-02-19 2018-08-17 Ciclacion enzimatica de acido homofarnesilico. MX2021002854A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16156410 2016-02-19

Publications (1)

Publication Number Publication Date
MX2021002854A true MX2021002854A (es) 2021-05-28

Family

ID=55446622

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018010024A MX380770B (es) 2016-02-19 2017-02-20 Ciclación enzimática de ácido homofarnesílico.
MX2021002854A MX2021002854A (es) 2016-02-19 2018-08-17 Ciclacion enzimatica de acido homofarnesilico.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018010024A MX380770B (es) 2016-02-19 2017-02-20 Ciclación enzimática de ácido homofarnesílico.

Country Status (9)

Country Link
US (2) US10954538B2 (es)
EP (2) EP3816297A1 (es)
JP (3) JP6989513B2 (es)
CN (1) CN109072265A (es)
BR (1) BR112018016789A2 (es)
ES (1) ES2854724T3 (es)
MX (2) MX380770B (es)
MY (1) MY196447A (es)
WO (1) WO2017140909A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11136611B2 (en) 2017-02-24 2021-10-05 Basf Se Method for the preparation of (3E,7E)-homofarnesic acid or (3E,7E)-homofarnesic acid ester
JP7203747B2 (ja) 2017-02-24 2023-01-13 ビーエーエスエフ ソシエタス・ヨーロピア アリルアルコール及びそれらのアシル化生成物のカルボニル化による不飽和カルボン酸の調製のための方法
CN107828709B (zh) * 2017-11-09 2021-06-25 天津大学 异源合成龙涎香醇的重组大肠杆菌及其构建方法
GB201917688D0 (en) * 2019-12-04 2020-01-15 Givaudan Sa SHC enzymes and enzyme variants
GB202005468D0 (en) * 2020-04-15 2020-05-27 Givaudan Sa Enzyme-media process
EP4359372B1 (de) 2021-06-21 2025-06-25 Basf Se Hydrierung von estern zu alkoholen in gegenwart eines mn-pnn-komplexes
EP4540381A1 (en) * 2022-06-15 2025-04-23 International Flavors & Fragrances Inc. Squalene hopene cyclase variants for producing sclareolide
CN117164538A (zh) * 2023-08-29 2023-12-05 新疆大学 一种一锅两步制备降龙涎醚的方法
WO2025093710A1 (en) 2023-11-02 2025-05-08 Basf Se Process for a stereoselective polyene cyclization
CN119552142A (zh) * 2024-11-29 2025-03-04 吉林大学 一种由降龙涎二醇合成降龙涎醚的方法

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US513270A (en) 1894-01-23 August friedrich wilhelm kreinsen
ATE72457T1 (de) 1983-07-13 1992-02-15 Basf K & F Corp Verfahren zur herstellung eines diols und eines furans und dazu faehiger mikroorganismus.
DE4027419A1 (de) 1990-08-30 1992-03-05 Huels Chemische Werke Ag Verfahren zur reaktivierung von desaktivierten hydrierkatalysatoren
DE19931847A1 (de) 1999-07-09 2001-01-11 Basf Ag Immobilisierte Lipase
DE10019373A1 (de) 2000-04-18 2001-10-31 Pfreundt Gmbh & Co Kg Vorrichtung und Verfahren zur Steuerung eines Maschinenbauteils
DE10019380A1 (de) 2000-04-19 2001-10-25 Basf Ag Verfahren zur Herstellung von kovalent gebundenen biologisch aktiven Stoffen an Polyurethanschaumstoffen sowie Verwendung der geträgerten Polyurethanschaumstoffe für chirale Synthesen
DE10019377A1 (de) 2000-04-19 2001-10-25 Basf Ag Verfahren zur Immobilisierung von biologisch aktiven Stoffen auf Trägermaterialien und Verwendung der mit biologisch aktiven Stoffen geträgerten Materialien für chirale Synthesen
CA2528425A1 (en) * 2003-06-18 2004-12-23 Basf Aktiengesellschaft Method for the microbiological isomerisation of alpha-hydroxy carboxylic acids
DE102004022686A1 (de) 2004-05-05 2005-11-24 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
DE102005010804A1 (de) 2005-03-07 2006-09-14 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
JP4854418B2 (ja) * 2006-07-28 2012-01-18 花王株式会社 ドデカヒドロ−３ａ，６，６，９ａ−テトラメチルナフト［２，１−ｂ］フラン原料の製造方法
CN104031945B (zh) * 2008-01-29 2017-08-11 弗门尼舍有限公司 生产香紫苏醇的方法
ES2703770T3 (es) * 2009-06-05 2019-03-12 Basf Se Preparación biocatalítica de ambroxán
JP6096667B2 (ja) 2010-11-17 2017-03-15 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ テルペンの生体触媒環化のための方法及びその方法で使用され得るシクラーゼ変異体
US8932839B2 (en) * 2010-11-17 2015-01-13 Basf Se Method for the biocatalytic cyclization of terpenes and cyclase mutants employable therein
EP2915797A1 (de) 2014-03-07 2015-09-09 Basf Se Verfahren zur Herstellung von Menthonen aus Isopulegol in der Gasphase
US10233169B2 (en) 2014-04-14 2019-03-19 Basf Se Production of 2-substituted 4-hydroxy-4-methyl-tetrahydropyrans from starting materials containing 2-alkyl-4,4-dimethyl-1,3-dioxanes
MX386539B (es) 2014-04-14 2025-03-18 Basf Se Producción de 4-hidroxi-4-metiltetrahidropiranos 2-sustituidos que tienen calidad odorífera estable.
EP2865676A1 (de) 2014-04-14 2015-04-29 Basf Se Herstellung von 2-substituierten 4-Methyl-tetrahydropyranen aus 2-Alkyl-4,4-dimethyl-1,3-dioxan-haltigen Ausgangsstoffen
US10017465B2 (en) 2014-08-12 2018-07-10 Basf Se Method for producing astaxanthin from astacin
CN106573886B (zh) 2014-08-12 2020-10-30 巴斯夫欧洲公司 由环状α-酮烯醇制备环状α-酮醇的方法
EP2985364A1 (en) 2014-08-14 2016-02-17 Basf Se Process for preparing alcohols by electrochemical reductive coupling
JP6738324B2 (ja) 2014-09-10 2020-08-12 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 糖基質の酵素的トランスリン酸化
CN106687443A (zh) 2014-09-11 2017-05-17 巴斯夫欧洲公司 生产虾青素酯的方法
BR112017004667A2 (pt) 2014-09-12 2018-01-30 Basf Se método para preparação de um composto, composto, uso de um composto, método para preparação de gêneros alimentícios, e, produto alimentar ou aditivo alimentar.
PL3197987T3 (pl) 2014-09-26 2019-07-31 Basf Se Zastosowanie izomerycznie czystego lub izomerycznie wysoce wzbogaconego octanu cis- lub trans- 2-izobutylo-4-metylotetrahydropiran-4-ylu
EP3201184B1 (de) 2014-09-29 2019-01-02 Basf Se Verfahren zur biokatalytischen cyclisierung von geranyllinalool und dabei erhaltene cyclisierungsprodukte
EP3002003A1 (de) 2014-09-30 2016-04-06 Basf Se Verwendung neuartiger cyclischer Carbaldehyde als Aromastoff
WO2016050909A1 (en) 2014-10-02 2016-04-07 Basf Se Process for purifying astaxanthin and canthaxanthin
PL3206756T3 (pl) 2014-10-14 2019-06-28 Basf Se Zastosowanie heksadeka-8,15-dienalu jako aromatycznej substancji chemicznej
JP2017535554A (ja) 2014-11-18 2017-11-30 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ １−（２，６，６−トリメチルシクロヘキシル）−アルカン−３−オールの調製方法
WO2016097238A1 (en) 2014-12-19 2016-06-23 Basf Se 1-(7,10,10-trimethyl-4-bicyclo(6.2.0)decanyl)ethanone as novel aroma chemical
WO2016097239A1 (en) 2014-12-19 2016-06-23 Basf Se Process for preparing 1-[(1r,4r/s,8s)-10,10-dimethyl-7-methylene-4-bicyclo[6.2.0]decanyl]ethanone
EP3483151B1 (de) 2015-03-05 2025-06-25 Basf Se Tetrahydropyranylester als riechstoffe
DE102015103608A1 (de) 2015-03-11 2016-09-15 Basf Se Verfahren zur mikrobiellen de novo Synthese von Terpenen
RU2017137403A (ru) 2015-03-26 2019-04-26 Басф Се Биокаталитическое получение l-фукозы
MX2017014148A (es) 2015-05-04 2018-03-15 Basf Se Proceso para la preparacion de melonal.
WO2016184948A1 (en) 2015-05-20 2016-11-24 Basf Se Process for preparing a macrocyclic diketone
WO2016193134A1 (de) 2015-05-29 2016-12-08 Basf Se Verfahren zur herstellung cyclischer ester
WO2016193330A1 (en) 2015-06-03 2016-12-08 Basf Se Process for preparing 3-methylcyclopentadecane-1,5-dione
BR112018000481B1 (pt) 2015-07-10 2022-01-11 Basf Se Processos para preparação de compostos e de (-)- ambrox (v)
CN107848930A (zh) 2015-07-15 2018-03-27 巴斯夫欧洲公司 制备芳基丙烯的方法
CN107848929A (zh) 2015-07-15 2018-03-27 巴斯夫欧洲公司 制备芳基丙烯的方法
MX395508B (es) 2015-08-18 2025-03-04 Basf Se Proceso para preparar a-damascona.
CN107848928B (zh) 2015-08-18 2022-04-15 巴斯夫欧洲公司 制备1,4-双(乙氧基甲基)环己烷的方法
JP6885930B2 (ja) 2015-09-22 2021-06-16 ビーエイエスエフ・ソシエタス・エウロパエアＢａｓｆ Ｓｅ ３−メチルシクロペンタデカン−１，５−ジオールを調製する方法
EP3153493A1 (de) 2015-10-08 2017-04-12 Basf Se Verfahren zur reinigung von cyclohexadec-8-en-1-on
WO2017060440A1 (de) 2015-10-08 2017-04-13 Basf Se Verwendung neuartiger gemische von (e/z)-cyclopentadecenon-isomeren, deren herstellung und deren verwendung als aromastoff
CN108350401B (zh) 2015-10-23 2021-06-04 巴斯夫欧洲公司 气味物质和芳香剂与乙烯基内酰胺聚合物的固溶体
EP3170828A1 (de) 2015-11-23 2017-05-24 Basf Se Verfahren zur herstellung von verbindungen mit 16-oxabicyclo[10.3.1]pentadecengerüst und deren folgeprodukten
ES2899827T3 (es) 2015-12-08 2022-03-14 Basf Se Material zeolítico que contiene estaño y que tiene una estructura de marco BEA

Also Published As

Publication number Publication date
ES2854724T3 (es) 2021-09-22
JP2019505222A (ja) 2019-02-28
EP3816297A1 (de) 2021-05-05
EP3417067B1 (de) 2020-11-18
JP6989513B2 (ja) 2022-01-05
BR112018016789A2 (pt) 2018-12-26
US20190144899A1 (en) 2019-05-16
MX380770B (es) 2025-03-12
MX2018010024A (es) 2018-11-09
WO2017140909A1 (de) 2017-08-24
MY196447A (en) 2023-04-12
JP7507739B2 (ja) 2024-06-28
US20210381013A1 (en) 2021-12-09
US10954538B2 (en) 2021-03-23
EP3417067A1 (de) 2018-12-26
CN109072265A (zh) 2018-12-21
JP2024038047A (ja) 2024-03-19
JP2022033873A (ja) 2022-03-02

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