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MX2020010034A - Metodo de tratamiento de enfermedad fibrotica. - Google Patents

Metodo de tratamiento de enfermedad fibrotica.

Info

Publication number
MX2020010034A
MX2020010034A MX2020010034A MX2020010034A MX2020010034A MX 2020010034 A MX2020010034 A MX 2020010034A MX 2020010034 A MX2020010034 A MX 2020010034A MX 2020010034 A MX2020010034 A MX 2020010034A MX 2020010034 A MX2020010034 A MX 2020010034A
Authority
MX
Mexico
Prior art keywords
treating fibrotic
methods
fibrotic disease
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Prior art date
Application number
MX2020010034A
Other languages
English (en)
Inventor
Brad Owen Buckman
Prabha Ibrahim
P T Ravi Rajagopalan
Original Assignee
Blade Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blade Therapeutics Inc filed Critical Blade Therapeutics Inc
Publication of MX2020010034A publication Critical patent/MX2020010034A/es

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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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Abstract

En la presente se describen métodos para tratar trastornos fibróticos por la administración de compuestos selectivos para CAPN1, CAPN2, y/o CAPN9 tal que se reduzcan al mínimo los efectos secundarios, interacciones fuera de ruta, y/o toxicidades. Estos métodos pueden, por ejemplo, reducir al mínimo los efectos no deseados de compuestos terapéuticos al proporcionar dosificación y formas de dosificación que reducen al mínimo el nivel de fármaco no unido dentro de los tejidos pertinentes de un paciente que se somete a tratamiento.
MX2020010034A 2018-03-28 2019-03-25 Metodo de tratamiento de enfermedad fibrotica. MX2020010034A (es)

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PCT/US2019/023917 WO2019190999A1 (en) 2018-03-28 2019-03-25 Method of treating fibrotic disease

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RU2020130022A (ru) * 2018-03-28 2022-05-04 Блэйд Терапьютикс, Инк. Модуляторы кальпаина и их терапевтическое применение
BR112020026744A2 (pt) * 2018-06-28 2021-03-30 Blade Therapeutics, Inc. Métodos para tratar fibrose hepática com o uso de inibidores de calpaína
CN116096714A (zh) 2020-06-10 2023-05-09 安力高医药股份有限公司 用于治疗冠状病毒、小核糖核酸病毒和诺罗病毒感染的抗病毒化合物
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