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MX2020009605A - Metodos para mejorar la viabilidad celular en un biorreactor de produccion. - Google Patents

Metodos para mejorar la viabilidad celular en un biorreactor de produccion.

Info

Publication number
MX2020009605A
MX2020009605A MX2020009605A MX2020009605A MX2020009605A MX 2020009605 A MX2020009605 A MX 2020009605A MX 2020009605 A MX2020009605 A MX 2020009605A MX 2020009605 A MX2020009605 A MX 2020009605A MX 2020009605 A MX2020009605 A MX 2020009605A
Authority
MX
Mexico
Prior art keywords
methods
cell viability
production bioreactor
improving cell
bioreactor
Prior art date
Application number
MX2020009605A
Other languages
English (en)
Inventor
Timothy Johnson
Jason Walther
Jonathan Wang
Neha Shah
Jiuyi Lu
Yukun Ren
Jean Mclarty
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of MX2020009605A publication Critical patent/MX2020009605A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18—Flow directing inserts
    • C12M27/20—Baffles; Ribs; Ribbons; Auger vanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/42—Means for regulation, monitoring, measurement or control, e.g. flow regulation of agitation speed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

En la presente memoria se proporcionan métodos para pronosticar el efecto de una concentración de un sensibilizador sobre la viabilidad celular en un biorreactor de producción, métodos para mejorar la viabilidad celular en un biorreactor de producción, métodos para pronosticar la viabilidad celular en un biorreactor de producción, y métodos para cultivar una célula en un biorreactor de producción.
MX2020009605A 2018-03-16 2019-03-15 Metodos para mejorar la viabilidad celular en un biorreactor de produccion. MX2020009605A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862644339P 2018-03-16 2018-03-16
US201862645755P 2018-03-20 2018-03-20
PCT/US2019/022530 WO2019178508A1 (en) 2018-03-16 2019-03-15 Methods for improving cell viability in a production bioreactor

Publications (1)

Publication Number Publication Date
MX2020009605A true MX2020009605A (es) 2021-01-08

Family

ID=65952204

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020009605A MX2020009605A (es) 2018-03-16 2019-03-15 Metodos para mejorar la viabilidad celular en un biorreactor de produccion.
MX2024009056A MX2024009056A (es) 2018-03-16 2020-09-15 Metodos para mejorar la viabilidad celular en un biorreactor de produccion.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2024009056A MX2024009056A (es) 2018-03-16 2020-09-15 Metodos para mejorar la viabilidad celular en un biorreactor de produccion.

Country Status (18)

Country Link
US (2) US11391725B2 (es)
EP (2) EP4512887A3 (es)
JP (2) JP2021515584A (es)
KR (2) KR20250016476A (es)
CN (2) CN112136045B (es)
AU (1) AU2019236246B2 (es)
BR (1) BR112020018823A2 (es)
CA (1) CA3094076C (es)
ES (1) ES3009097T3 (es)
HU (1) HUE069711T2 (es)
IL (2) IL319295A (es)
MA (1) MA52007A (es)
MX (2) MX2020009605A (es)
PL (1) PL3765846T3 (es)
SG (1) SG11202009047TA (es)
TW (2) TW202513790A (es)
WO (1) WO2019178508A1 (es)
ZA (2) ZA202005741B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2023054556A1 (es) 2021-09-30 2023-04-06
US12157873B2 (en) 2022-09-28 2024-12-03 Genzyme Corporation Systems and devices for producing biological products and methods of using the same
US20240263122A1 (en) * 2023-02-08 2024-08-08 National Central University Bioreactor apparatus, ion-exchange substrate and method for regulation of ion concentration and cell culture thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5563068A (en) * 1994-04-21 1996-10-08 Genetic Therapy, Inc. Bioreactor
WO2006089002A2 (en) * 2005-02-15 2006-08-24 Yale University Method for high throughput screening for antibodies and proteins inducing apoptosis
EP2500415A1 (en) * 2006-09-13 2012-09-19 Abbott Laboratories Cell culture improvements
TWI548747B (zh) * 2006-09-13 2016-09-11 艾伯維有限公司 細胞培養改良
JP2010525833A (ja) * 2007-05-07 2010-07-29 プロタリクス リミテッド 大規模な使い捨て型バイオリアクター
WO2010120514A2 (en) 2009-03-31 2010-10-21 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
KR101808496B1 (ko) * 2009-07-31 2017-12-12 백스터 인터내셔널 인코포레이티드 Adamts 단백질 발현을 위한 세포 배양 배지
US20150353883A1 (en) * 2013-01-10 2015-12-10 Biogen Ma Inc. Medium Supplements for Improved Process Performance
CN105209603A (zh) * 2013-02-22 2015-12-30 建新公司 微载体灌注培养方法及其用途
WO2014151901A1 (en) * 2013-03-14 2014-09-25 Abbvie Inc. Improvement of mammalian cell culture performance through surfactant supplementation of feed media
CA2905180C (en) * 2013-03-15 2023-03-07 Alder Biopharmaceuticals, Inc. Temperature shift for high yield expression of polypeptides in yeast and other transformed cells
US20160131634A1 (en) * 2013-05-29 2016-05-12 Biogen Ma Inc. Methods of evaluating cell culture additives
PT3110961T (pt) * 2014-02-27 2020-01-29 Hoffmann La Roche Modulação do crescimento celular e da glicosilação na produção de glicoproteínas recombinantes
IL253071B2 (en) * 2014-12-22 2024-04-01 Genzyme Corp Methods for growing mammalian cells
TWI541353B (zh) * 2014-12-25 2016-07-11 財團法人工業技術研究院 產生嗜熱性鹼性蛋白酶生產菌屬（Ｔｅｐｉｄｉｍｏｎａｓ）之胞外蛋白的方法
CN108350440A (zh) * 2015-08-17 2018-07-31 阿雷克森制药公司 碱性磷酸酯的制造

Also Published As

Publication number Publication date
AU2019236246B2 (en) 2025-06-05
AU2019236246A1 (en) 2020-11-12
KR102757905B1 (ko) 2025-01-22
US20220308042A1 (en) 2022-09-29
RU2020133815A (ru) 2022-04-19
HUE069711T2 (hu) 2025-04-28
PL3765846T3 (pl) 2025-03-31
ZA202208613B (en) 2025-01-29
CA3094076A1 (en) 2019-09-19
CN112136045A (zh) 2020-12-25
EP4512887A2 (en) 2025-02-26
ZA202005741B (en) 2023-04-26
IL277352A (en) 2020-11-30
CN112136045B (zh) 2024-12-13
TW202513790A (zh) 2025-04-01
MX2024009056A (es) 2024-07-29
ES3009097T3 (en) 2025-03-26
SG11202009047TA (en) 2020-10-29
WO2019178508A1 (en) 2019-09-19
TW201947033A (zh) 2019-12-16
EP3765846B1 (en) 2024-10-30
IL277352B2 (en) 2025-08-01
EP3765846C0 (en) 2024-10-30
BR112020018823A2 (pt) 2021-02-09
US11391725B2 (en) 2022-07-19
IL319295A (en) 2025-04-01
US20190285617A1 (en) 2019-09-19
JP2021515584A (ja) 2021-06-24
KR20200132932A (ko) 2020-11-25
KR20250016476A (ko) 2025-02-03
IL277352B1 (en) 2025-04-01
EP3765846A1 (en) 2021-01-20
EP4512887A3 (en) 2025-04-30
MA52007A (fr) 2021-01-20
JP2024023489A (ja) 2024-02-21
CA3094076C (en) 2025-11-25
TWI835779B (zh) 2024-03-21
CN119709931A (zh) 2025-03-28

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