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MX2020009272A - Receptores de antígeno quimérico del antígeno de membrana específico de próstata y métodos de uso de los mismos. - Google Patents

Receptores de antígeno quimérico del antígeno de membrana específico de próstata y métodos de uso de los mismos.

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Publication number
MX2020009272A
MX2020009272A MX2020009272A MX2020009272A MX2020009272A MX 2020009272 A MX2020009272 A MX 2020009272A MX 2020009272 A MX2020009272 A MX 2020009272A MX 2020009272 A MX2020009272 A MX 2020009272A MX 2020009272 A MX2020009272 A MX 2020009272A
Authority
MX
Mexico
Prior art keywords
modified
prostate
cells
psma
receptor
Prior art date
Application number
MX2020009272A
Other languages
English (en)
Inventor
Yangbing Zhao
Szu Hua Sharon Lin
Xiaojun Liu
Anne Chew
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of MX2020009272A publication Critical patent/MX2020009272A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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Abstract

La presente descripción proporciona células inmunes modificadas (por ejemplo, células T modificadas) que comprenden un receptor de antígeno quimérico (CAR) que tiene afinidad por un antígeno de membrana específico de próstata (PSMA) (por ejemplo, PSMA de humano); la presente descripción proporciona células inmunes modificadas (por ejemplo, células T modificadas) que comprenden un CAR que tiene afinidad por PSMA y un receptor negativo dominante y/o receptor de cambio; la presente descripción proporciona células inmunes modificadas (por ejemplo, células T modificadas) que comprenden un CAR que tiene afinidad por PSMA y un receptor negativo dominante y/o un receptor de cambio, en donde la célula modificada es capaz de expresar y secretar un anticuerpo biespecífico.
MX2020009272A 2018-03-06 2019-03-05 Receptores de antígeno quimérico del antígeno de membrana específico de próstata y métodos de uso de los mismos. MX2020009272A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862639321P 2018-03-06 2018-03-06
PCT/US2019/020729 WO2019173324A1 (en) 2018-03-06 2019-03-05 Prostate-specific membrane antigen cars and methods of use thereof

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MX2020009272A true MX2020009272A (es) 2021-01-08

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US (3) US10780120B2 (es)
EP (2) EP3762410A4 (es)
JP (4) JP7526097B2 (es)
KR (1) KR20200130709A (es)
CN (1) CN112119157B (es)
AU (2) AU2019231205A1 (es)
CA (2) CA3093078A1 (es)
MX (1) MX2020009272A (es)
TW (2) TW201940520A (es)
WO (2) WO2019173324A1 (es)

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