MX2020008173A - Combinacion de un agente antimuscarinico o de uno anticolinergico y acido lipoico, y sus usos. - Google Patents
Combinacion de un agente antimuscarinico o de uno anticolinergico y acido lipoico, y sus usos.Info
- Publication number
- MX2020008173A MX2020008173A MX2020008173A MX2020008173A MX2020008173A MX 2020008173 A MX2020008173 A MX 2020008173A MX 2020008173 A MX2020008173 A MX 2020008173A MX 2020008173 A MX2020008173 A MX 2020008173A MX 2020008173 A MX2020008173 A MX 2020008173A
- Authority
- MX
- Mexico
- Prior art keywords
- antimuscarinic
- lipoic acid
- anticholinergic agent
- formula
- combination
- Prior art date
Links
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 title abstract 4
- 230000001022 anti-muscarinic effect Effects 0.000 title abstract 4
- 239000000812 cholinergic antagonist Substances 0.000 title abstract 4
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 title abstract 4
- 235000019136 lipoic acid Nutrition 0.000 title abstract 4
- 229960002663 thioctic acid Drugs 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000003149 muscarinic antagonist Substances 0.000 abstract 1
- 239000006069 physical mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente divulgación se refiere a composiciones farmacéuticas que comprende una cantidad terapéuticamente efectiva de un agente antimuscarínico o de uno anticolinérgico, o de una sal o de un estereoisómero farmacéuticamente aceptable de los mismos, en combinación con una cantidad terapéuticamente efectiva de ácido lipoico, o de una sal o de un estereoisómero farmacéuticamente aceptable del mismo. El agente antimuscarínico o anticolinérgico es un compuesto de la Fórmula I, Formula II, o Formula III, y el ácido lipoico es un compuesto de la Fórmula IV o Formula V. La composición farmacéutica es una mezcla física de un agente antimuscarínico o de uno anticolinérgico y ácido lipoico.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201841004306 | 2018-02-05 | ||
| IN201841008091 | 2018-03-05 | ||
| PCT/IB2019/050901 WO2019150341A1 (en) | 2018-02-05 | 2019-02-05 | Combination of an antimuscarinic or an anticholinergic agent and lipoic acid and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020008173A true MX2020008173A (es) | 2020-09-25 |
Family
ID=67480013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020008173A MX2020008173A (es) | 2018-02-05 | 2019-02-05 | Combinacion de un agente antimuscarinico o de uno anticolinergico y acido lipoico, y sus usos. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20200375961A1 (es) |
| EP (1) | EP3749303A4 (es) |
| JP (1) | JP2021512876A (es) |
| KR (1) | KR20200118128A (es) |
| AU (1) | AU2019214557A1 (es) |
| BR (1) | BR112020015436A2 (es) |
| CA (1) | CA3089894A1 (es) |
| IL (1) | IL276350A (es) |
| MX (1) | MX2020008173A (es) |
| RU (1) | RU2020122659A (es) |
| SG (1) | SG11202006492SA (es) |
| WO (1) | WO2019150341A1 (es) |
| ZA (1) | ZA202004058B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3522873T3 (da) * | 2016-10-04 | 2022-06-20 | Cellix Bio Private Ltd | Sammensætninger og fremgangsmåder til behandlingen af xerostomi |
| CA3126328A1 (en) * | 2019-01-12 | 2020-07-16 | Cellix Bio Private Limited | Combination of selective alpha-adrenergic receptor agonist or an anticholinergic agent and lipoic acid and uses thereof |
| CN113387923A (zh) * | 2020-03-13 | 2021-09-14 | 诺华股份有限公司 | 硫辛酸胆碱酯盐的药物组合物及使用其的治疗方法 |
| IL298476A (en) * | 2020-05-26 | 2023-01-01 | Cellix Bio Private Ltd | Pharmaceutical formulations of pilocarpine r-(+)-lipoate |
| WO2022080529A1 (ko) * | 2020-10-15 | 2022-04-21 | 경상대학교병원 | 침분비 저하증 예방 또는 치료용 약학적 조성물 및 건강기능식품 |
| WO2023052974A1 (en) * | 2021-09-29 | 2023-04-06 | Avaca Pharma Private Limited | Ocular compositions and methods for the treatment of ophthalmic diseases and disorders |
| WO2023052977A1 (en) * | 2021-09-29 | 2023-04-06 | Avaca Pharma Private Limited | Compositions, methods and uses thereof |
| CN119454701A (zh) * | 2022-01-18 | 2025-02-18 | 苏州普乐康医药科技有限公司 | 一种含西维美林的眼用制剂及其制备方法和应用 |
| TW202329958A (zh) * | 2022-01-25 | 2023-08-01 | 張金明 | 西維美林水溶液組合物和使用方法 |
| CN118679159A (zh) * | 2022-01-29 | 2024-09-20 | 南京济群医药科技股份有限公司 | 一种m-胆碱受体激动剂化合物及其制备方法和用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3608073A (en) * | 1968-07-16 | 1971-09-21 | Barnes Hind Pharm Inc | Emulsion of pilocarpine for ophthalmic use |
| EP1758597B1 (en) * | 2004-05-20 | 2012-09-12 | Diamedica Inc. | Use of drug combinations for treating insulin resistance |
| JP2006070027A (ja) * | 2004-08-06 | 2006-03-16 | Dai Ichi Seiyaku Co Ltd | 口腔粘膜投与剤 |
| WO2006013914A1 (ja) * | 2004-08-06 | 2006-02-09 | Daiichi Pharmaceutical Co., Ltd. | 口腔粘膜投与剤 |
| DK1965787T3 (da) * | 2005-11-30 | 2013-06-03 | Endo Pharmaceuticals Inc | Behandling af xerostomi med en svovlindeholdende antioxidant |
| UA86441C2 (ru) * | 2007-03-30 | 2009-04-27 | Акционерное Общество Открытого Типа "Галичфарм" | (2-гидроксиэтил)триметиламмония тиоктат (холина тиоктат), имеющий гепатопротекторное, гипоаммониемическое и детоксицирующее действие, способ его получения, фармацевтическая композиция на его основе |
| US20090263467A1 (en) * | 2008-04-21 | 2009-10-22 | Hemant Narahar Joshi | Combination drug therapy using orally dissolving film or orally disintegrating tablet dosage forms to treat dry mouth ailments |
| PL2821405T3 (pl) * | 2009-06-15 | 2017-08-31 | Encore Health, Llc | Estry cholinowe do leczenia prezbiopii i zaćmy |
| PT2498771E (pt) * | 2009-11-12 | 2014-01-30 | Acacia Pharma Ltd | Uso do betanecol para o tratamento de xerostomia |
| US10507245B2 (en) * | 2012-07-19 | 2019-12-17 | Luis Felipe Vejarano Restrepo | Ophthalmic formulation and method for ameliorating presbyopia |
| WO2014059309A1 (en) * | 2012-10-11 | 2014-04-17 | Theravida, Inc. | Pharmaceutical formulations of pilocarpine |
| KR101586789B1 (ko) * | 2012-12-28 | 2016-01-19 | 주식회사 종근당 | 양이온성 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물 |
| US9427144B2 (en) * | 2014-01-03 | 2016-08-30 | Ophthalmx Llc | Methods and systems for detecting ophthalmic disease |
| CA2936146A1 (en) * | 2014-01-06 | 2015-07-09 | Stealth Biotherapeutics Corp | Methods and compositions for preventing or treating dominant optic atrophy |
| DK3522873T3 (da) * | 2016-10-04 | 2022-06-20 | Cellix Bio Private Ltd | Sammensætninger og fremgangsmåder til behandlingen af xerostomi |
| CN111372576A (zh) * | 2017-11-17 | 2020-07-03 | 塞尔利克斯生物私人有限公司 | 用于治疗眼部病症的组合物和方法 |
| CA3126328A1 (en) * | 2019-01-12 | 2020-07-16 | Cellix Bio Private Limited | Combination of selective alpha-adrenergic receptor agonist or an anticholinergic agent and lipoic acid and uses thereof |
-
2019
- 2019-02-05 BR BR112020015436-9A patent/BR112020015436A2/pt not_active Application Discontinuation
- 2019-02-05 JP JP2020542141A patent/JP2021512876A/ja active Pending
- 2019-02-05 SG SG11202006492SA patent/SG11202006492SA/en unknown
- 2019-02-05 MX MX2020008173A patent/MX2020008173A/es unknown
- 2019-02-05 KR KR1020207025451A patent/KR20200118128A/ko not_active Ceased
- 2019-02-05 WO PCT/IB2019/050901 patent/WO2019150341A1/en not_active Ceased
- 2019-02-05 CA CA3089894A patent/CA3089894A1/en active Pending
- 2019-02-05 EP EP19747106.3A patent/EP3749303A4/en not_active Withdrawn
- 2019-02-05 AU AU2019214557A patent/AU2019214557A1/en not_active Abandoned
- 2019-02-05 RU RU2020122659A patent/RU2020122659A/ru unknown
-
2020
- 2020-07-02 ZA ZA2020/04058A patent/ZA202004058B/en unknown
- 2020-07-28 IL IL276350A patent/IL276350A/en unknown
- 2020-08-04 US US16/985,187 patent/US20200375961A1/en not_active Abandoned
-
2022
- 2022-11-23 US US17/993,868 patent/US20230310391A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019214557A1 (en) | 2020-08-20 |
| WO2019150341A1 (en) | 2019-08-08 |
| CA3089894A1 (en) | 2019-08-08 |
| EP3749303A4 (en) | 2022-01-26 |
| JP2021512876A (ja) | 2021-05-20 |
| EP3749303A1 (en) | 2020-12-16 |
| KR20200118128A (ko) | 2020-10-14 |
| RU2020122659A (ru) | 2022-03-09 |
| SG11202006492SA (en) | 2020-08-28 |
| BR112020015436A2 (pt) | 2020-12-22 |
| IL276350A (en) | 2020-09-30 |
| ZA202004058B (en) | 2021-08-25 |
| US20200375961A1 (en) | 2020-12-03 |
| US20230310391A1 (en) | 2023-10-05 |
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