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MX2020003543A - Metodo de produccion de un compuesto intermediario para sintetizar un medicamento. - Google Patents

Metodo de produccion de un compuesto intermediario para sintetizar un medicamento.

Info

Publication number
MX2020003543A
MX2020003543A MX2020003543A MX2020003543A MX2020003543A MX 2020003543 A MX2020003543 A MX 2020003543A MX 2020003543 A MX2020003543 A MX 2020003543A MX 2020003543 A MX2020003543 A MX 2020003543A MX 2020003543 A MX2020003543 A MX 2020003543A
Authority
MX
Mexico
Prior art keywords
intermediate compound
preparing intermediate
pharmaceutical synthesis
pharmaceutical
synthesis
Prior art date
Application number
MX2020003543A
Other languages
English (en)
Inventor
Ae Ri Park
Seok Ju Lee
Bongchan Kim
In Ae Ryu
Jongwon Park
Original Assignee
Lg Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd
Priority claimed from KR1020180115838A external-priority patent/KR102152445B1/ko
Publication of MX2020003543A publication Critical patent/MX2020003543A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La presente invención se refiere a un método para la preparación de un compuesto de fórmula química 2 que es un intermediario usado para sintetizar antidiabéticos que inhiben la enzima dipeptidil peptidasa IV, que 1) puede producirlo en alta pureza mediante una ciclación y deciclación de oxazolidinona que la convierte en una amida, 2) es capaz de aumentar el rendimiento y aumentar la productividad mediante la estabilización del procedimiento de preparación, y 3) puede lograr un efecto de mejora tal como reducción del costo de materias primas, etc. usando un material de partida de una muestra económica.
MX2020003543A 2017-09-28 2018-09-28 Metodo de produccion de un compuesto intermediario para sintetizar un medicamento. MX2020003543A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20170126119 2017-09-28
PCT/KR2018/011565 WO2019066578A1 (ko) 2017-09-28 2018-09-28 의약품 합성용 중간체 화합물의 제조 방법
KR1020180115838A KR102152445B1 (ko) 2017-09-28 2018-09-28 의약품 합성용 중간체 화합물의 제조 방법

Publications (1)

Publication Number Publication Date
MX2020003543A true MX2020003543A (es) 2020-07-29

Family

ID=65902150

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020003543A MX2020003543A (es) 2017-09-28 2018-09-28 Metodo de produccion de un compuesto intermediario para sintetizar un medicamento.

Country Status (2)

Country Link
MX (1) MX2020003543A (es)
WO (1) WO2019066578A1 (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5705985B2 (ja) * 2010-09-03 2015-04-22 エルジー・ライフ・サイエンシーズ・リミテッドＬＧ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． 医薬品合成用中間体化合物の製造方法

Also Published As

Publication number Publication date
WO2019066578A1 (ko) 2019-04-04

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