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MX2020001450A - Composiciones para reducir la inmunosupresion por celulas de tumor. - Google Patents

Composiciones para reducir la inmunosupresion por celulas de tumor.

Info

Publication number
MX2020001450A
MX2020001450A MX2020001450A MX2020001450A MX2020001450A MX 2020001450 A MX2020001450 A MX 2020001450A MX 2020001450 A MX2020001450 A MX 2020001450A MX 2020001450 A MX2020001450 A MX 2020001450A MX 2020001450 A MX2020001450 A MX 2020001450A
Authority
MX
Mexico
Prior art keywords
compositions
tumor cells
reducing immunosuppression
methods
shrna
Prior art date
Application number
MX2020001450A
Other languages
English (en)
Inventor
W Wucherpfennig Kai
Dranoff Glenn
Zhou Penghui
SHAFFER Donald
Hacohen Nir
I Cantor Harvey
Alvarez Arias Diana
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of MX2020001450A publication Critical patent/MX2020001450A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C12Q2600/00—Oligonucleotides characterized by their use
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Abstract

La presente invención provee, en parte, métodos de descubrimiento de objetivos de inmunoterapia in vivo, composiciones terapéuticas (p. ej., ARNhp, células inmunorrespondedoras que expresan ARNhp y/o receptores de antígeno quiméricos (CAR)), y métodos de uso de los mismos.
MX2020001450A 2013-06-10 2015-12-09 Composiciones para reducir la inmunosupresion por celulas de tumor. MX2020001450A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361833298P 2013-06-10 2013-06-10
US201361921303P 2013-12-27 2013-12-27
US201461929821P 2014-01-21 2014-01-21

Publications (1)

Publication Number Publication Date
MX2020001450A true MX2020001450A (es) 2020-03-24

Family

ID=51063858

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015016963A MX2015016963A (es) 2013-06-10 2014-06-10 Metodos y composiciones para reducir la inmunosupresion por celulas de tumor.
MX2020001450A MX2020001450A (es) 2013-06-10 2015-12-09 Composiciones para reducir la inmunosupresion por celulas de tumor.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015016963A MX2015016963A (es) 2013-06-10 2014-06-10 Metodos y composiciones para reducir la inmunosupresion por celulas de tumor.

Country Status (11)

Country Link
US (4) US9944931B2 (es)
EP (2) EP3008173B1 (es)
JP (3) JP6546160B2 (es)
KR (3) KR102301464B1 (es)
CN (1) CN105431524B (es)
AU (2) AU2014278323B2 (es)
CA (2) CA3051222C (es)
EA (1) EA035475B1 (es)
ES (1) ES2897579T3 (es)
MX (2) MX2015016963A (es)
WO (1) WO2014201021A2 (es)

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