[go: up one dir, main page]

MX2020001272A - Anticuerpos dirigidos contra interleucina-33 (il-33). - Google Patents

Anticuerpos dirigidos contra interleucina-33 (il-33).

Info

Publication number
MX2020001272A
MX2020001272A MX2020001272A MX2020001272A MX2020001272A MX 2020001272 A MX2020001272 A MX 2020001272A MX 2020001272 A MX2020001272 A MX 2020001272A MX 2020001272 A MX2020001272 A MX 2020001272A MX 2020001272 A MX2020001272 A MX 2020001272A
Authority
MX
Mexico
Prior art keywords
chain polypeptide
directed against
antibodies directed
against interleukin
binding agent
Prior art date
Application number
MX2020001272A
Other languages
English (en)
Inventor
Robert A Horlick
David J King
Andrew John Mcknight
Original Assignee
Anaptysbio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anaptysbio Inc filed Critical Anaptysbio Inc
Publication of MX2020001272A publication Critical patent/MX2020001272A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a un polipéptido de cadena pesada de inmunoglobulina aislado y un polipéptido de cadena ligera de inmunoglobulina aislado que se enlazan a interleucina-33 (IL-33). La invención proporciona un agente de enlace a IL-33 que comprende el polipéptido de cadena pesada de inmunoglobulina y el polipéptido de cadena ligera de inmunoglobulina anteriormente mencionados. La invención también proporciona vectores, composiciones, y métodos relacionados al uso del agente de enlace a IL-33 para tratar un trastorno en un mamífero que responde a inhibición de IL-33.
MX2020001272A 2014-01-10 2016-07-08 Anticuerpos dirigidos contra interleucina-33 (il-33). MX2020001272A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461925946P 2014-01-10 2014-01-10

Publications (1)

Publication Number Publication Date
MX2020001272A true MX2020001272A (es) 2020-07-20

Family

ID=53524474

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016009047A MX2016009047A (es) 2014-01-10 2015-01-09 Anticuerpos dirigidos contra interleucina-33 (il-33).
MX2020001272A MX2020001272A (es) 2014-01-10 2016-07-08 Anticuerpos dirigidos contra interleucina-33 (il-33).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016009047A MX2016009047A (es) 2014-01-10 2015-01-09 Anticuerpos dirigidos contra interleucina-33 (il-33).

Country Status (13)

Country Link
US (4) US10059764B2 (es)
EP (1) EP3092253B1 (es)
JP (2) JP2017503506A (es)
KR (1) KR102446386B1 (es)
CN (1) CN106103480B (es)
AU (1) AU2015204674B2 (es)
BR (1) BR112016016020B1 (es)
ES (1) ES2866935T3 (es)
MX (2) MX2016009047A (es)
NZ (1) NZ722445A (es)
RU (1) RU2693084C2 (es)
SG (2) SG10201805934RA (es)
WO (1) WO2015106080A2 (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2004697A2 (en) 2006-04-07 2008-12-24 The Procter & Gamble Company Antibodies that bind human protein tyrosine phosphatase beta (hptpbeta) and uses thereof
CA2850830A1 (en) 2011-10-13 2013-04-18 Aerpio Therapeutics, Inc. Methods for treating vascular leak syndrome and cancer
JO3532B1 (ar) 2013-03-13 2020-07-05 Regeneron Pharma الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها
CA2904377C (en) 2013-03-15 2021-07-13 Regeneron Pharmaceuticals, Inc. Il-33 antagonists and uses thereof
MX381087B (es) 2013-12-26 2025-03-12 Mitsubishi Tanabe Pharma Corp Anticuerpo monoclonal neutralizador de anti-il-33 humana.
EP3092253B1 (en) 2014-01-10 2021-03-17 AnaptysBio, Inc. Antibodies directed against interleukin-33 (il-33)
WO2016077366A1 (en) 2014-11-10 2016-05-19 Genentec, Inc. Therapeutic and diagnostic methods for il-33-mediated disorders
BR112017009728A2 (pt) 2014-11-10 2018-02-06 Genentech, Inc. anticorpos isolados, ácido nucleico isolado, vetor, célula hospedeira, método para produzir o anticorpo, composição, usos de um anticorpo e métodos de tratamento de um distúrbio
AU2017208099A1 (en) * 2016-01-14 2018-08-09 Anaptysbio, Inc. Inhibition of allergic reaction using an IL-33 inhibitor
JP2019516362A (ja) 2016-04-27 2019-06-20 ファイザー・インク 抗ｉｌ−３３抗体、その組成物、方法および使用
KR20190031246A (ko) 2016-07-20 2019-03-25 에르피오 세러퓨틱스 인코포레이티드 VE-PTP (HPTP-β)를 표적으로 하는 인간화된 단클론성 항체
JOP20190093A1 (ar) 2016-10-28 2019-04-25 Lilly Co Eli أجسام مضادة لـ il-33 واستخداماتها
TWI857389B (zh) 2016-12-01 2024-10-01 美商再生元醫藥公司 治療發炎症狀的方法
WO2018115960A1 (en) 2016-12-19 2018-06-28 Mosaic Biomedicals, S.L. Antibodies against lif and uses thereof
BR112019012691A2 (pt) 2016-12-19 2019-11-19 Fundacio Privada Inst Catalana De Recerca I Estudis Avancats anticorpos contra a lif e seus usos
US10738131B2 (en) 2017-02-10 2020-08-11 Genentech, Inc. Anti-tryptase antibodies, compositions thereof, and uses thereof
KR102605045B1 (ko) 2017-04-13 2023-11-27 리제너론 파마슈티칼스 인코포레이티드 Il33 및 il1rl1을 코딩하는 유전자에서의 위험 대립유전자를 갖는 환자에서의 폐 질환의 치료 및 저해
CN115920031A (zh) 2017-08-31 2023-04-07 田边三菱制药株式会社 含有il-33拮抗剂的子宫内膜异位症治疗剂
US20200239562A1 (en) 2017-10-09 2020-07-30 Anaptysbio, Inc. Anti-il-33 therapy for atopic dermatitis
JP7418337B2 (ja) 2018-02-09 2024-01-19 ジェネンテック， インコーポレイテッド マスト細胞媒介性炎症性疾患の治療法及び診断法
WO2019183639A1 (en) * 2018-03-23 2019-09-26 Anaptysbio, Inc. Inhibition of allergic reaction to peanut allergen using an il-33 inhibitor
IL307286B1 (en) 2018-04-11 2025-11-01 Regeneron Pharma Methods and compositions for quantifying il-33
TW202021983A (zh) 2018-09-21 2020-06-16 美商安納普提斯生物公司 用於嗜伊紅性氣喘之抗il-33療法
CN120058958A (zh) 2018-09-24 2025-05-30 视点制药公司 靶向HPTP-β（VE-PTP）和VEGF的多特异性抗体
KR20220092927A (ko) 2019-11-04 2022-07-04 메디뮨 리미티드 신장 장애를 치료하기 위한 항 il-33 치료제
TW202134261A (zh) 2019-11-04 2021-09-16 英商梅迪繆思有限公司 使用il-33拮抗劑之方法
JP7722195B2 (ja) 2020-02-05 2025-08-13 日油株式会社 膵液瘻の予防または治療剤
PE20230252A1 (es) * 2020-03-13 2023-02-07 Genentech Inc Anticuerpos anti-interleucina-33 y sus usos de estos
EP4118236A1 (en) 2020-03-13 2023-01-18 MedImmune Limited Therapeutic methods for the treatment of subjects with risk alelles in il33
US20230174637A1 (en) 2020-04-06 2023-06-08 Medimmune Limited Treating acute respiratory distress syndrome with il-33 axis binding antagonists
IL297841A (en) 2020-05-11 2023-01-01 Medimmune Ltd Formulations of anti-il-33 antibodies
EP4151654A4 (en) * 2020-05-12 2024-11-27 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. St2 antigen binding protein
US12065507B2 (en) * 2020-06-01 2024-08-20 University Of Kentucky Research Foundation Compounds and methods for use in connection with opioid use disorders
EP4178565A4 (en) * 2020-07-07 2024-11-27 The General Hospital Corporation INHIBITION OF INTERLEUKIN 33 (IL-33) FOR THE TREATMENT OF CANCER, FIBROSIS AND INFLAMMATION
KR102789102B1 (ko) * 2020-08-18 2025-03-28 성균관대학교산학협력단 Il-33 항체 또는 이의 항원 결합 단편
CN114249825A (zh) * 2020-09-25 2022-03-29 三生国健药业（上海）股份有限公司 结合人il-33的抗体、其制备方法和用途
CN113603775B (zh) 2021-09-03 2022-05-20 江苏荃信生物医药股份有限公司 抗人白介素-33单克隆抗体及其应用
EP4430072A1 (en) 2021-11-10 2024-09-18 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
TW202402790A (zh) 2022-03-25 2024-01-16 英商梅迪繆思有限公司 減少呼吸系統感染之方法
TW202423973A (zh) 2022-08-19 2024-06-16 英商梅迪繆思有限公司 選擇患者以用ｉｌ—３３軸拮抗劑進行治療之方法
WO2025114862A1 (en) * 2023-11-27 2025-06-05 Glaxosmithkline Intellectual Property Development Limited Il-33 binding antibodies
WO2025120567A1 (en) 2023-12-07 2025-06-12 Medimmune Limited Method of treatment of asthma
TW202540173A (zh) 2024-04-04 2025-10-16 英商梅迪繆思有限公司 治療及選擇對象之方法
WO2025242618A1 (en) 2024-05-20 2025-11-27 Medimmune Limited Bronchiectasis treatment

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4828981A (en) 1983-08-24 1989-05-09 Synbiotics Corporation Immunoassays for determining Dirofilaria immitis infection using antiidiotype monoclonal antibody reagents
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
WO1992008796A1 (en) 1990-11-13 1992-05-29 Immunex Corporation Bifunctional selectable fusion genes
AU6953394A (en) 1993-05-21 1994-12-20 Targeted Genetics Corporation Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene
US5814618A (en) 1993-06-14 1998-09-29 Basf Aktiengesellschaft Methods for regulating gene expression
US5464758A (en) 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
FR2814642B1 (fr) 2000-10-03 2005-07-01 Ass Pour Le Dev De La Rech En Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
CA2467633C (en) 2001-12-03 2012-03-27 Abgenix, Inc. Antibody categorization based on binding characteristics
NZ549040A (en) 2004-02-17 2009-07-31 Schering Corp Use for interleukin-33 (IL33) and the IL-33 receptor complex
US20070048785A1 (en) * 2004-06-09 2007-03-01 Lin Laura L Anti-IL-13 antibodies and complexes
PL1915398T3 (pl) * 2005-07-18 2016-10-31 Ludzkie przeciwciała neutralizujące anty-B7RP1
WO2007130627A2 (en) 2006-05-04 2007-11-15 The Brigham And Women's Hospital, Inc. Il-33 in the treatment and diagnosis of diseases and disorders
US7560530B1 (en) * 2006-07-20 2009-07-14 Schering Corporation IL-33 receptor
CN101512008B (zh) 2006-09-08 2015-04-01 艾伯维巴哈马有限公司 白介素-13结合蛋白
EP2126105A4 (en) 2007-02-20 2010-11-03 Anaptysbio Inc SOMATIC HYPERPERMUTATION SYSTEMS
CA2685124A1 (en) 2007-04-26 2008-11-06 Provost, Fellows And Scholars Of The College Of The Holy And Undivided T Rinity Of Queen Elizabeth Near Dublin Products for altering il-33 activity and methods therefor
AU2008254704A1 (en) 2007-05-18 2008-11-27 Medimmune, Llc IL-33 in inflammatory disease
MX2010014364A (es) * 2008-06-30 2011-08-12 Morphotek Inc Anticuerpos anti-gd2 y metodos y usos relacionados con los mismos.
RU2011135768A (ru) 2009-01-29 2013-03-10 Эбботт Лэборетриз Белки, связывающие il-1
US20120263709A1 (en) 2009-09-10 2012-10-18 Schering Corporation Use of il-33 antagonists to treat fibrotic diseases
WO2011047328A1 (en) 2009-10-15 2011-04-21 Avaxia Biologics, Inc. Antibody therapeutics with local activity in the digestive tract
KR101848225B1 (ko) 2010-05-14 2018-04-12 애브비 인코포레이티드 Ｉｌ－１ 결합 단백질
CN105440134A (zh) * 2010-08-16 2016-03-30 安姆根公司 结合肌肉生长抑制素的抗体、组合物和方法
BR112013010714A2 (pt) 2010-11-01 2024-01-16 Rib X Pharmaceuticals Inc Composição farmacêutica e uso de um composto antibiótico
TWI732259B (zh) 2010-12-16 2021-07-01 美商建南德克公司 關於th2抑制作用之診斷及治療
WO2012103240A2 (en) 2011-01-25 2012-08-02 Eleven Biotherapeutics, Inc. Receptor binding agents
FR2972006B1 (fr) 2011-02-24 2016-03-25 Centre Nat Rech Scient Nouveaux fragments d'il-33 superactifs et leurs utilisations
TW201323440A (zh) 2011-10-24 2013-06-16 Abbvie Inc 抗骨硬化素（ｓｃｌｅｒｏｓｔｉｎ）之免疫結合物
US9932402B2 (en) 2011-10-27 2018-04-03 Nkt Therapeutics Inc. Humanized antibodies to iNKT
US9260756B2 (en) 2012-02-24 2016-02-16 Children's Hospital Medical Center Esophageal microRNA expression profiles in eosinophilic esophagitis
US9212227B2 (en) 2012-04-30 2015-12-15 Janssen Biotech, Inc. ST2L antibody antagonists for the treatment of ST2L-mediated inflammatory pulmonary conditions
UY34813A (es) 2012-05-18 2013-11-29 Amgen Inc Proteínas de unión a antígeno dirigidas contra el receptor st2
RU2015105178A (ru) 2012-07-31 2016-09-20 Новартис Аг Лечение воспаления с использованием серелаксина
US20150250808A1 (en) 2012-10-15 2015-09-10 Vojo P. Deretic Treatment of autophagy-based disorders and related pharmaceutical compositions, diagnostic and screening assays and kits
WO2014090800A1 (en) 2012-12-10 2014-06-19 Vib Vzw Novel interleukin-33 inhibitors
KR101780575B1 (ko) 2013-02-14 2017-09-21 건국대학교 산학협력단 신규한 인터루킨-33 수용체와 결합 단백질 조성물 및 그 용도
JO3532B1 (ar) 2013-03-13 2020-07-05 Regeneron Pharma الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها
CA2904377C (en) 2013-03-15 2021-07-13 Regeneron Pharmaceuticals, Inc. Il-33 antagonists and uses thereof
TR201903312T4 (tr) 2013-08-12 2019-04-22 Astrazeneca Ab Benralizumab kullanarak astım alevlenme oranlarini azaltma yöntemleri.
KR101567758B1 (ko) 2013-10-17 2015-11-11 인하대학교 산학협력단 항-Siglec-8 항체 또는 항-Siglec-F 항체, 및 항-IL-33 항체를 포함하는 알러지 질환의 예방 또는 치료용 조성물
SG11201603127WA (en) 2013-10-23 2016-05-30 Genentech Inc Methods of diagnosing and treating eosinophilic disorders
MX381087B (es) 2013-12-26 2025-03-12 Mitsubishi Tanabe Pharma Corp Anticuerpo monoclonal neutralizador de anti-il-33 humana.
EP3092253B1 (en) 2014-01-10 2021-03-17 AnaptysBio, Inc. Antibodies directed against interleukin-33 (il-33)
EP3119913B1 (en) 2014-03-21 2021-01-06 The Brigham and Women's Hospital, Inc. Methods and compositions for treatment of immune-related diseases or disorders and/or therapy monitoring
GB201406608D0 (en) 2014-04-12 2014-05-28 Psioxus Therapeutics Ltd Virus
US10040859B2 (en) 2014-04-21 2018-08-07 The Children's Hospital Of Philadelphia Methods of treating hemophagocytic lymphohistiocytosis with an IL-33 receptor antibody
WO2016077366A1 (en) 2014-11-10 2016-05-19 Genentec, Inc. Therapeutic and diagnostic methods for il-33-mediated disorders
BR112017009728A2 (pt) 2014-11-10 2018-02-06 Genentech, Inc. anticorpos isolados, ácido nucleico isolado, vetor, célula hospedeira, método para produzir o anticorpo, composição, usos de um anticorpo e métodos de tratamento de um distúrbio
CA2978449A1 (en) 2015-03-02 2016-09-09 180 Therapeutics Lp Method of treating a localized fibrotic disorder using an il-33 antagonist
EP3095440B1 (en) 2015-05-19 2020-01-15 PLS-Design GmbH Antigen-specific immunotherapy using tolerizing liposomes
US10005834B2 (en) 2015-10-06 2018-06-26 Regeneron Pharmaceuticals, Inc. Biomarkers related to interleukin-33 (IL-33)-mediated diseases and uses thereof
AU2017208099A1 (en) 2016-01-14 2018-08-09 Anaptysbio, Inc. Inhibition of allergic reaction using an IL-33 inhibitor

Also Published As

Publication number Publication date
AU2015204674B2 (en) 2020-09-03
US11999783B2 (en) 2024-06-04
KR102446386B1 (ko) 2022-09-22
US20160333090A1 (en) 2016-11-17
SG10201805934RA (en) 2018-08-30
BR112016016020A2 (pt) 2018-05-22
US20240294631A1 (en) 2024-09-05
RU2016132757A (ru) 2018-02-16
JP6882702B2 (ja) 2021-06-02
US10059764B2 (en) 2018-08-28
MX2016009047A (es) 2017-04-13
CA2936366A1 (en) 2015-07-16
RU2693084C2 (ru) 2019-07-01
CN106103480A (zh) 2016-11-09
US10836820B2 (en) 2020-11-17
EP3092253A4 (en) 2017-11-29
EP3092253B1 (en) 2021-03-17
JP2017503506A (ja) 2017-02-02
AU2015204674A1 (en) 2016-08-25
CN106103480B (zh) 2021-10-22
SG11201605580RA (en) 2016-10-28
RU2016132757A3 (es) 2018-07-16
WO2015106080A2 (en) 2015-07-16
ES2866935T3 (es) 2021-10-20
KR20160132006A (ko) 2016-11-16
RU2019118984A (ru) 2019-08-06
US20180346562A1 (en) 2018-12-06
NZ722445A (en) 2022-07-01
JP2020018309A (ja) 2020-02-06
WO2015106080A3 (en) 2015-09-11
US20210040198A1 (en) 2021-02-11
BR112016016020B1 (pt) 2024-02-27
EP3092253A2 (en) 2016-11-16

Similar Documents

Publication Publication Date Title
MX2020001272A (es) Anticuerpos dirigidos contra interleucina-33 (il-33).
ZA201706740B (en) Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3)
PH12018502225A1 (en) Anti-il-33 antibodies, compositions, methods and uses thereof
MX2022002364A (es) Anticuerpos anti-pd-l1.
EA201791029A1 (ru) Антитела против интерлейкина-33 и их применение
ZA201708265B (en) Tigit-binding agents and uses thereof
MX2021003704A (es) Anticuerpos heterodimericos que se unen a cd3 y a antigenos tumorales.
MX372817B (es) Anticuerpos dirigidos contra la proteína muerte programada-1 (pd-1).
SG10201907161YA (en) Antibodies directed against lymphocyte activation gene 3 (lag-3)
PH12017500982A1 (en) Heterodimeric antibodies that bind cd3 and cd38
EA201891992A1 (ru) Химерные рецепторы и способы их применения
PH12017502019B1 (en) Heterodimeric antibodies that bind cd3 and tumor antigens
NZ728688A (en) Anti-pd-1 antibodies
EP4491195A3 (en) Bispecific tetravalent antibodies and methods of makiing and using thereof
NZ724815A (en) Humanized antibodies that bind lgr5
NZ730186A (en) Humanized anti-hepcidin antibodies and uses thereof
ZA201800804B (en) Novel anti-human gpvi antibodies and uses thereof
MX2023006786A (es) Anticuerpos inmunomoduladores biespecificos que se fijan a receptores coestimuladores y de puntos de control.
EA201992315A1 (ru) Композиции и способы для лечения рака легкого
EA201891528A1 (ru) Композиции и способы обнаружения и лечения рака желудка
MX2018011244A (es) Anticuerpos monoclonales neutralizantes para il-25 y usos de estos.
MX2017003014A (es) Anticuerpos anti-alfa v beta 5 humanizados y usos de estos.
WO2015116569A3 (en) Antibodies directed against discoidin domain receptor family, member 1 (ddr1)
MX2018009218A (es) Anticuerpos de cgrp y sus usos.
MX2019002349A (es) Anticuerpos inmunomoduladores biespecíficos que se fijan a receptores coestimuladores y de puntos de control.