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MX2019014173A - Formación de imágenes con iluminación estructurada por selección espacial de ángulo de patrón. - Google Patents

Formación de imágenes con iluminación estructurada por selección espacial de ángulo de patrón.

Info

Publication number
MX2019014173A
MX2019014173A MX2019014173A MX2019014173A MX2019014173A MX 2019014173 A MX2019014173 A MX 2019014173A MX 2019014173 A MX2019014173 A MX 2019014173A MX 2019014173 A MX2019014173 A MX 2019014173A MX 2019014173 A MX2019014173 A MX 2019014173A
Authority
MX
Mexico
Prior art keywords
imaging system
sim
sim imaging
implementations
implemented
Prior art date
Application number
MX2019014173A
Other languages
English (en)
Inventor
Peter Clarke Newman
Stanley S Hong
Aaron Liu
Simon Prince
Merek C Siu
Danilo Condello
Shaoping Lu
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Priority claimed from PCT/US2019/013504 external-priority patent/WO2019143564A1/en
Publication of MX2019014173A publication Critical patent/MX2019014173A/es

Links

Classifications

    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/06Means for illuminating specimens
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458Fluorescence microscopy
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6486Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052Optical details of the image generation
    • G02B21/0076Optical details of the image generation arrangements using fluorescence or luminescence
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/18Arrangements with more than one light path, e.g. for comparing two specimens
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/36Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/361Optical details, e.g. image relay to the camera or image sensor
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/36Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365Control or image processing arrangements for digital or video microscopes
    • G02B21/367Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/42Diffraction optics, i.e. systems including a diffractive element being designed for providing a diffractive effect
    • G02B27/4233Diffraction optics, i.e. systems including a diffractive element being designed for providing a diffractive effect having a diffractive element [DOE] contributing to a non-imaging application
    • G02B27/425Diffraction optics, i.e. systems including a diffractive element being designed for providing a diffractive effect having a diffractive element [DOE] contributing to a non-imaging application in illumination systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N2021/6463Optics
    • G01N2021/6471Special filters, filter wheel
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N2021/6463Optics
    • G01N2021/6478Special lenses
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/58Optics for apodization or superresolution; Optical synthetic aperture systems

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Multimedia (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Length Measuring Devices By Optical Means (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

La descripción proporciona sistemas formadores de imágenes de microscopia de iluminación estructurada (SIM). En un conjunto de implementaciones, un sistema formador de imágenes SIM puede implementarse como un sistema formador de imágenes SIM de múltiples brazos, por lo que cada brazo del sistema incluye un emisor de luz y un divisor de haz (por ejemplo, una rejilla de difracción transmisiva) que tiene una orientación específica y fija con respecto al eje óptico del sistema. En un segundo conjunto de implementaciones, un sistema formador de imagen SIM puede implementarse como un sistema formador de imágenes SIM de diapositiva de múltiples divisores de haz, donde se monta una plataforma de movimiento lineal con múltiples divisores de haz que tienen una orientación fija correspondiente con respecto al eje óptico del sistema. En un tercer conjunto de implementaciones, se puede implementar un sistema formador de imágenes SIM como un sistema formador de imágenes SIM de selección espacial de ángulo de patrón, mediante el cual se usa una rejilla de difracción bidimensional fija en combinación con una rueda de filtro espacial para proyectar patrones de franjas unidimensionales en una muestra.
MX2019014173A 2018-01-16 2019-01-14 Formación de imágenes con iluminación estructurada por selección espacial de ángulo de patrón. MX2019014173A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862618059P 2018-01-16 2018-01-16
NL2020620A NL2020620B1 (en) 2018-01-16 2018-03-20 Pattern angle spatial selection structured illumination imaging
PCT/US2019/013504 WO2019143564A1 (en) 2018-01-16 2019-01-14 Pattern angle spatial selection structured illumination imaging

Publications (1)

Publication Number Publication Date
MX2019014173A true MX2019014173A (es) 2021-02-09

Family

ID=61868834

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019014173A MX2019014173A (es) 2018-01-16 2019-01-14 Formación de imágenes con iluminación estructurada por selección espacial de ángulo de patrón.

Country Status (16)

Country Link
US (1) US10996453B2 (es)
EP (1) EP3628075B1 (es)
JP (1) JP6916316B2 (es)
KR (1) KR102312777B1 (es)
CN (1) CN209979487U (es)
AU (1) AU2019209204B2 (es)
CA (1) CA3066483C (es)
IL (1) IL271048B (es)
MX (1) MX2019014173A (es)
MY (1) MY198394A (es)
NL (1) NL2020620B1 (es)
NZ (1) NZ759623A (es)
RU (1) RU2740206C1 (es)
SA (1) SA519410845B1 (es)
SG (1) SG11201911584YA (es)
TW (1) TWI710864B (es)

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Also Published As

Publication number Publication date
SG11201911584YA (en) 2020-01-30
JP6916316B2 (ja) 2021-08-11
CA3066483A1 (en) 2019-07-25
RU2740206C1 (ru) 2021-01-12
IL271048B (en) 2022-05-01
SA519410845B1 (ar) 2022-06-16
CA3066483C (en) 2022-06-28
IL271048A (en) 2020-01-30
TW201932991A (zh) 2019-08-16
JP2020532758A (ja) 2020-11-12
KR102312777B1 (ko) 2021-10-14
CN209979487U (zh) 2020-01-21
AU2019209204B2 (en) 2021-06-17
AU2019209204A1 (en) 2020-11-26
BR112019028316A2 (pt) 2020-07-14
TWI710864B (zh) 2020-11-21
NL2020620B1 (en) 2019-07-25
KR20200019148A (ko) 2020-02-21
US20200218050A1 (en) 2020-07-09
MY198394A (en) 2023-08-28
US10996453B2 (en) 2021-05-04
EP3628075A1 (en) 2020-04-01
NZ759623A (en) 2022-05-27
EP3628075A4 (en) 2020-07-15
EP3628075B1 (en) 2023-01-25

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