[go: up one dir, main page]

MX2019012902A - Preparacion de derivados de acido 2-([1,2,3]triazol-2-il)-benzoico . - Google Patents

Preparacion de derivados de acido 2-([1,2,3]triazol-2-il)-benzoico .

Info

Publication number
MX2019012902A
MX2019012902A MX2019012902A MX2019012902A MX2019012902A MX 2019012902 A MX2019012902 A MX 2019012902A MX 2019012902 A MX2019012902 A MX 2019012902A MX 2019012902 A MX2019012902 A MX 2019012902A MX 2019012902 A MX2019012902 A MX 2019012902A
Authority
MX
Mexico
Prior art keywords
triazol
preparation
benzoic acid
formula
derivatives
Prior art date
Application number
MX2019012902A
Other languages
English (en)
Other versions
MX392154B (es
Inventor
Dörrwächter Patric
Schmidt Gunther
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of MX2019012902A publication Critical patent/MX2019012902A/es
Publication of MX392154B publication Critical patent/MX392154B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/70—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper
    • B01J23/72—Copper
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un proceso para la preparación de derivados de ácido 2-(2H-[1,2,3]triazol-2-iI)-benzoico particulares de la fórmula (I) (ver Fórmula) a ciertas formas cristalinas de sales de potasio de dichos derivados de ácido 2-(2H-[1,2,3]triazol-2-il)-benzoico de la fórmula (lK), a ciertas formas cristalinas de dichos derivados de ácido 2-(2H-[1,2,3]triazol-2-il)-benzoico de la fórmula (I) y a su uso en la preparación de farmacéuticos tales como (S)-(2-(5-cloro-4-metil-1H-benzo[d]imidazol-2-il)-2-metilpirrolid in-1-il)-(5-metoxi-2-(2H-1,2,3-triazol-2-il)fenil)metanona.
MX2019012902A 2017-05-03 2018-05-02 Preparacion de derivados de acido 2-([1,2,3]triazol-2-il)-benzoico. MX392154B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2017060451 2017-05-03
PCT/EP2018/061172 WO2018202689A1 (en) 2017-05-03 2018-05-02 Preparation of 2-([1,2,3]triazol-2-yl)-benzoic acid derivatives

Publications (2)

Publication Number Publication Date
MX2019012902A true MX2019012902A (es) 2019-12-16
MX392154B MX392154B (es) 2025-03-21

Family

ID=62116854

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019012902A MX392154B (es) 2017-05-03 2018-05-02 Preparacion de derivados de acido 2-([1,2,3]triazol-2-il)-benzoico.

Country Status (20)

Country Link
US (1) US11124488B2 (es)
EP (1) EP3619199B1 (es)
JP (1) JP7182562B2 (es)
KR (1) KR102582197B1 (es)
CN (1) CN110612291B (es)
CA (1) CA3059394C (es)
CY (1) CY1124777T1 (es)
DK (1) DK3619199T3 (es)
ES (1) ES2892161T3 (es)
HR (1) HRP20211304T1 (es)
HU (1) HUE055904T2 (es)
IL (1) IL270274B (es)
LT (1) LT3619199T (es)
MX (1) MX392154B (es)
PL (1) PL3619199T3 (es)
PT (1) PT3619199T (es)
RS (1) RS62357B1 (es)
SI (1) SI3619199T1 (es)
TW (1) TWI756418B (es)
WO (1) WO2018202689A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12022552763A1 (en) 2020-04-19 2024-03-25 Idorsia Pharmaceuticals Ltd Medical use of daridorexant
TW202400149A (zh) 2022-05-13 2024-01-01 瑞士商愛杜西亞製藥有限公司 經噻唑并芳基-甲基取代之環狀肼-n-甲醯胺衍生物
CN118724879B (zh) * 2023-12-19 2025-02-11 南京知和医药科技有限公司 一种氘代稠环化合物及其制备方法与用途
ES3038762A1 (es) * 2024-04-12 2025-10-14 Moehs Iberica Sl Procedimiento de síntesis de ácido 5-metoxi-2-(2H-1,2,3-triazol-2yl)benzoico, sal sódica de dicho ácido como intermedio de síntesis y uso del ácido o de su sal en la preparación de daridorexant y ciertos intermedios en la síntesis del mismo

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7994336B2 (en) 2006-08-15 2011-08-09 Actelion Pharmaceuticals Ltd. Azetidine compounds as orexin receptor antagonists
ATE481383T1 (de) 2006-09-29 2010-10-15 Actelion Pharmaceuticals Ltd 3-aza-bicycloä3.1.0ühexanderivate
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
CL2007003827A1 (es) 2006-12-28 2008-09-26 Actelion Pharmaceuticals Ltd Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras.
DE602008002934D1 (de) 2007-05-14 2010-11-18 Actelion Pharmaceuticals Ltd 2-cyclopropylthiazolderivate
AU2008260647A1 (en) 2007-05-23 2008-12-11 Merck Sharp & Dohme Corp. Cyclopropyl pyrrolidine orexin receptor antagonists
SI2491038T1 (sl) 2009-10-23 2016-08-31 Janssen Pharmaceutica N.V. Disubstituirani oktahil-dropirolo(3,4-c)piroli kot modulatorji oreksinskega receptorja
WO2011050200A1 (en) 2009-10-23 2011-04-28 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
JP5848251B2 (ja) 2009-10-23 2016-01-27 ヤンセン ファーマシューティカ エヌ．ベー． オレキシン受容体調節因子としての縮合複素環式化合物
CA2821893A1 (en) 2010-12-17 2012-06-21 Taisho Pharmaceutical Co., Ltd. Pyrazole derivative
WO2012085852A1 (en) 2010-12-22 2012-06-28 Actelion Pharmaceuticals Ltd 3,8-diaza-bicyclo[4.2.0]oct-8-yl amides
EP2680697B1 (en) 2011-03-03 2018-01-10 Merck Sharp & Dohme Corp. Process for the preparation of an orexin receptor antagonist
WO2012145581A1 (en) 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
EP2730573A4 (en) 2011-07-05 2014-12-03 Taisho Pharmaceutical Co Ltd METHYLPIPERIDINDERIVAT
WO2013050938A1 (en) * 2011-10-04 2013-04-11 Actelion Pharmaceuticals Ltd 3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives
EA024106B1 (ru) 2011-11-08 2016-08-31 Актелион Фармасьютиклз Лтд. Производные 2-(1,2,3-триазол-2-ил)бензамида и 3-(1,2,3-триазол-2-ил)пиколинамида
US9441254B2 (en) 2012-05-09 2016-09-13 Merck Sharp & Dohme Corp. Process for the preparation of an intermediate for an orexin receptor antagonist
KR101689093B1 (ko) 2012-06-04 2016-12-22 액테리온 파마슈티칼 리미티드 벤즈이미다졸-프롤린 유도체
JP2014015452A (ja) 2012-06-15 2014-01-30 Taisho Pharmaceutical Co Ltd ピラゾール誘導体を含有する医薬
JP6244365B2 (ja) 2012-10-10 2017-12-06 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ ［オルトビ−（ヘテロ−）アリール］−［２−（メタビ−（ヘテロ−）アリール）−ピロリジン−１−イル］−メタノン誘導体であるオレキシン受容体アンタゴニスト
CN105051040A (zh) 2013-03-12 2015-11-11 埃科特莱茵药品有限公司 作为食欲素受体拮抗剂的氮杂环丁烷酰胺衍生物
TW201444849A (zh) * 2013-03-13 2014-12-01 Janssen Pharmaceutica Nv 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途
TW201444821A (zh) 2013-03-13 2014-12-01 Janssen Pharmaceutica Nv 經取代之哌啶化合物及其作為食慾素受體調節劑之用途
WO2015083070A1 (en) * 2013-12-03 2015-06-11 Actelion Pharmaceuticals Ltd Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone and its use as orexin receptor antagonists
UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
MX366642B (es) 2013-12-04 2019-07-17 Idorsia Pharmaceuticals Ltd Uso de derivados de bencimidazol-prolina.
WO2015123355A1 (en) * 2014-02-12 2015-08-20 Eolas Therapeutics, Inc. Substituted prolines / piperidines as orexin receptor antagonists
WO2016020403A1 (en) 2014-08-04 2016-02-11 Sandoz Ag Preparation of a benzoic acid derivative and its use for the preparation of suvorexant
CN104649983B (zh) * 2014-12-23 2018-01-23 广东东阳光药业有限公司 一种酸的制备方法
WO2016171248A1 (ja) * 2015-04-24 2016-10-27 武田薬品工業株式会社 複素環化合物

Also Published As

Publication number Publication date
SI3619199T1 (sl) 2021-11-30
CN110612291B (zh) 2024-02-13
IL270274B (en) 2022-08-01
CN110612291A (zh) 2019-12-24
WO2018202689A1 (en) 2018-11-08
PT3619199T (pt) 2021-10-01
EP3619199A1 (en) 2020-03-11
IL270274A (es) 2019-12-31
JP2020518573A (ja) 2020-06-25
TW201843144A (zh) 2018-12-16
KR102582197B1 (ko) 2023-09-22
US20210114997A1 (en) 2021-04-22
DK3619199T3 (da) 2021-09-27
US11124488B2 (en) 2021-09-21
CA3059394A1 (en) 2018-11-08
LT3619199T (lt) 2021-09-27
CA3059394C (en) 2023-09-12
PL3619199T3 (pl) 2021-12-20
EP3619199B1 (en) 2021-07-07
HRP20211304T1 (hr) 2021-11-12
TWI756418B (zh) 2022-03-01
KR20200003097A (ko) 2020-01-08
MX392154B (es) 2025-03-21
HUE055904T2 (hu) 2021-12-28
JP7182562B2 (ja) 2022-12-02
ES2892161T3 (es) 2022-02-02
CY1124777T1 (el) 2022-11-25
RS62357B1 (sr) 2021-10-29

Similar Documents

Publication Publication Date Title
BR102014006322B8 (pt) 4-amino-6-picolinatos(heterocílicos) e 6-amino-2-pirimidina-(heterocíclica)-4-carboxilatos, e processo para controle de vegetação indesejada
MX379536B (es) Compuestos de pirimidinio sustituido y derivados para combatir plagas de animales.
CR20140057A (es) Compuestos fungicidas de 1-{2-[2-halo-4-(4-halogen-fenoxi)-fenil]-2-etoxi-etil}-1h-[1,2,4]triazol sustituidos
SA113340696B1 (ar) تصنيع 2-(5-برومو-4-(4-سيكلو بروبيل نافثالين-1-يل)-4 h-1، 2، 4- ترازول-3- يل ثيو) حمض أسيتيك
CU20170057A7 (es) Derivados de feniltriazol sustituido con hidroxialquilo
UY34219A (es) Compuestos de 2-(2,4,5-anilino sustituido)pirimidina
MX365744B (es) Derivados de sulfuro de trifluoroetilo o sustituidos con n-arilamidina como acaricidas e insecticidas.
UY34480A (es) Compuestos de 2-(fenilo sustituido)-ciclopentan-1,3-diona y derivados de los mismos, composiciones y métodos para controlar malezas.
BR112014030674A2 (pt) compostos n-ariltriazol como antagonistas do lpar
PE20142448A1 (es) Compuestos de n-alquiltriazol como antagonistas de lpar
CR20140038A (es) Compuestos fungicidas de 1-{2-[2-halo-4-(4-halogen-fenoxi)-fenil]-2-alquiniloxi-etil}-1h-[1,2,4]triazol sustituidos
CR20140464A (es) Compuestos de heterociclilo
ECSP13012596A (es) Proceso de elaboración para derivados de pirimidina
BR112013016982A2 (pt) formas polimórficas de ácido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acético e usos destes
MX2019012902A (es) Preparacion de derivados de acido 2-([1,2,3]triazol-2-il)-benzoico .
BR112015033042A8 (pt) composto de azina, processos para a preparação de composto de azina, composição agroquímica, processo para a preparação de composições agroquímicas, método para controlar vegetação e uso do composto de azina
MX380799B (es) Ácidos propiónicos 3-sustituidos como inhibidores de la integrina alfa v.
MX371337B (es) Compuestos para protección de células.
MX2012004311A (es) Derivados de ciclohexano spiro condensados como inhibidores de lipasa sensible a hormonas (hsl) utiles en el tratamiento de diabetes.
TW201613904A (en) Pyridone derivatives containing tetrahydropyranylmethyl group
CR20140217A (es) Compuestos de 1,2,5-oxadiazol sustituido y su uso como herbicidas ii
MX2018009501A (es) Forma cristalina a de agonista de tlr7, metodo de preparacion y uso de la misma.
CR20160073A (es) Compuestos plaguicidas
GT201500292A (es) Formas cristalinas de inhibidores de tirosina cinasa y sus sales
WO2015049645A3 (en) An improved process for the preparation of dasatinib