MX2019010563A - Desarrollo y uso de sondas fluorescentes de bilirrubina sin enlazar. - Google Patents
Desarrollo y uso de sondas fluorescentes de bilirrubina sin enlazar.Info
- Publication number
- MX2019010563A MX2019010563A MX2019010563A MX2019010563A MX2019010563A MX 2019010563 A MX2019010563 A MX 2019010563A MX 2019010563 A MX2019010563 A MX 2019010563A MX 2019010563 A MX2019010563 A MX 2019010563A MX 2019010563 A MX2019010563 A MX 2019010563A
- Authority
- MX
- Mexico
- Prior art keywords
- probes
- unbounded
- fluorescent
- development
- bilirubin
- Prior art date
Links
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 title abstract 6
- 239000000523 sample Substances 0.000 title abstract 5
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 2
- 235000018417 cysteine Nutrition 0.000 abstract 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/728—Bilirubin; including biliverdin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/146666—Bile pigment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Se describe la identificación y uso de proteínas marcadas fluorescentemente y que sufren un cambio en el índice de fluorescencia después del enlace a bilirrubina. Se revelan sondas que son marcadas en un residuo de cisteína o lisina y también sondas marcadas tanto en cisteína como en lisina con dos fluoróforos diferentes. Estas sondas son útiles para la determinación de niveles de bilirrubina sin enlazar en una muestra del fluido.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161527849P | 2011-08-26 | 2011-08-26 | |
| PCT/US2012/052395 WO2013032953A2 (en) | 2011-08-26 | 2012-08-24 | Development and use of fluorescent probes of unbound bilirubin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019010563A true MX2019010563A (es) | 2019-10-24 |
| MX380526B MX380526B (es) | 2025-03-12 |
Family
ID=47757131
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014002051A MX347754B (es) | 2011-08-26 | 2012-08-24 | Desarrollo y uso de sondas fluorescentes de bilirrubina sin enlazar. |
| MX2019010563A MX380526B (es) | 2011-08-26 | 2012-08-24 | Desarrollo y uso de sondas fluorescentes de bilirrubina sin enlazar |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014002051A MX347754B (es) | 2011-08-26 | 2012-08-24 | Desarrollo y uso de sondas fluorescentes de bilirrubina sin enlazar. |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US9529003B2 (es) |
| EP (2) | EP2748615B1 (es) |
| JP (3) | JP6104913B2 (es) |
| CN (2) | CN104220877B (es) |
| AU (3) | AU2012300319B8 (es) |
| CA (1) | CA2846106C (es) |
| CY (1) | CY1122022T1 (es) |
| DK (1) | DK2748615T3 (es) |
| ES (1) | ES2733974T3 (es) |
| MX (2) | MX347754B (es) |
| PT (1) | PT2748615T (es) |
| WO (1) | WO2013032953A2 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2920204B1 (en) * | 2012-11-16 | 2019-09-18 | IBA GmbH | Streptavidin muteins and methods of using them |
| EP2963115B1 (en) * | 2013-02-28 | 2020-04-01 | Riken | Novel polypeptide exhibiting fluorescent properties and use thereof |
| WO2015084894A1 (en) | 2013-12-03 | 2015-06-11 | Alan Kleinfeld | Determination of the unbound free fatty acid profiles in biological and industrial specimens |
| US20160146838A1 (en) * | 2014-11-20 | 2016-05-26 | Jean Ronald Brisard | System and method for ebola detection |
| CN104819981B (zh) * | 2015-05-16 | 2017-11-21 | 山东耀华医疗器械股份有限公司 | 一种尿液成分测量仪 |
| US11078254B2 (en) * | 2017-04-11 | 2021-08-03 | National Institute Of Advanced Industrial Science And Technology | Method for immobilizing lectin |
| JP7166429B2 (ja) * | 2018-04-03 | 2022-11-07 | ネオメトリックス ディーエックス， インコーポレイテッド | ビリルビンのｉｎ ｖｉｖｏ毒性レベルを評価し、ビリルビン神経毒性の増大したリスクを診断するための、方法およびデバイス |
| CN111334079A (zh) * | 2018-12-18 | 2020-06-26 | 中国科学院大连化学物理研究所 | 一种全光谱高亮度、高稳定性荧光染料及其合成和应用 |
| US20230053493A1 (en) * | 2019-08-30 | 2023-02-23 | Alan Marc Kleinfeld | One step methods, kits, and systems for the measurement of concentrations of unbound bilirubin in biological fluids |
| CN111239094B (zh) * | 2020-03-13 | 2022-08-26 | 河南中医药大学 | 一种碱性磷酸酶的灵敏检测方法 |
| CN113238041B (zh) * | 2021-01-13 | 2024-01-16 | 军事科学院军事医学研究院环境医学与作业医学研究所 | 一种基于β-环糊精修饰的免疫生物条形码增敏探针以及快速检测阿特拉津的方法 |
| US11908583B2 (en) * | 2022-05-02 | 2024-02-20 | Kpn Innovations, Llc. | Apparatus and method for determining toxic load quantifiers |
| WO2025065355A1 (zh) * | 2023-09-27 | 2025-04-03 | 京东方科技集团股份有限公司 | 针对亨廷顿舞蹈症的早期诊断的多肽探针和试剂盒 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5470714A (en) | 1989-12-12 | 1995-11-28 | Lidak Pharmaceuticals | One-step free fatty acid determination method |
| US6444432B1 (en) | 1997-06-13 | 2002-09-03 | Alan M. Kleinfeld | Method of detection of cardiac ischemia using fatty acid binding protein |
| JP4719403B2 (ja) | 2000-08-15 | 2011-07-06 | ディサーナ リミテッド | 機能的タンパク質アレイ |
| EP2821793B1 (en) * | 2004-03-22 | 2017-04-19 | FFA Sciences, LLP | Development and use of fluorescent probes of unbound analytes |
| US20060257938A1 (en) * | 2005-05-10 | 2006-11-16 | Kleinfeld Alan M | Method of screening for drugs that block ligand binding to a lipid binding protein |
| WO2008060841A2 (en) * | 2006-10-27 | 2008-05-22 | Ffa Sciences, Llc | Use of probes for unbound metabolites |
| US9134317B2 (en) | 2008-01-18 | 2015-09-15 | Alan Kleinfeld | Development and use of cysteine-labeled fluorescent probes of unbound analytes |
-
2012
- 2012-08-24 CA CA2846106A patent/CA2846106C/en active Active
- 2012-08-24 MX MX2014002051A patent/MX347754B/es active IP Right Grant
- 2012-08-24 ES ES12827317T patent/ES2733974T3/es active Active
- 2012-08-24 DK DK12827317.4T patent/DK2748615T3/da active
- 2012-08-24 CN CN201280041789.4A patent/CN104220877B/zh active Active
- 2012-08-24 JP JP2014527346A patent/JP6104913B2/ja active Active
- 2012-08-24 PT PT12827317T patent/PT2748615T/pt unknown
- 2012-08-24 EP EP12827317.4A patent/EP2748615B1/en active Active
- 2012-08-24 CN CN201711257192.4A patent/CN108051584B/zh active Active
- 2012-08-24 WO PCT/US2012/052395 patent/WO2013032953A2/en not_active Ceased
- 2012-08-24 US US14/238,144 patent/US9529003B2/en active Active
- 2012-08-24 AU AU2012300319A patent/AU2012300319B8/en active Active
- 2012-08-24 MX MX2019010563A patent/MX380526B/es unknown
- 2012-08-24 EP EP19159898.6A patent/EP3598139A1/en active Pending
-
2016
- 2016-11-17 US US15/354,188 patent/US10295551B2/en active Active
-
2017
- 2017-03-01 JP JP2017038572A patent/JP6694403B2/ja not_active Expired - Fee Related
- 2017-07-25 AU AU2017208236A patent/AU2017208236B2/en active Active
-
2019
- 2019-03-11 JP JP2019043964A patent/JP6847141B2/ja active Active
- 2019-03-27 US US16/366,143 patent/US11029320B2/en active Active
- 2019-07-16 AU AU2019206014A patent/AU2019206014B2/en active Active
- 2019-07-29 CY CY20191100805T patent/CY1122022T1/el unknown
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