MX2019010150A - Uso de biomarcadores en la identificacion de pacientes con cancer que seran sensibles al tratamiento con un inhibidor de prmt5. - Google Patents
Uso de biomarcadores en la identificacion de pacientes con cancer que seran sensibles al tratamiento con un inhibidor de prmt5.Info
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- MX2019010150A MX2019010150A MX2019010150A MX2019010150A MX2019010150A MX 2019010150 A MX2019010150 A MX 2019010150A MX 2019010150 A MX2019010150 A MX 2019010150A MX 2019010150 A MX2019010150 A MX 2019010150A MX 2019010150 A MX2019010150 A MX 2019010150A
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- treatment
- biomarkers
- responsive
- cancer patients
- identifying cancer
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- G01N33/575—
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Primary Health Care (AREA)
- Data Mining & Analysis (AREA)
- Databases & Information Systems (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
Abstract
La presente invencion se refiere a un metodo de identificacion de un paciente que es probable que sea sensible al tratamiento con un inhibidor de proteina arginina N-metiltransferasa 5 (PRMT5) que comprende; evaluar una muestra biologica del paciente para detectar la presencia de una alteracion del espliceosoma, en el que la presencia de cualquiera de dicha alteracion indica una mayor probabilidad de que dicho paciente sea sensible al tratamiento con dicho inhibidor de PRMT5 que en ausencia de cualquiera de dicha mutacion o alteracion.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762464006P | 2017-02-27 | 2017-02-27 | |
| PCT/EP2018/054644 WO2018154104A1 (en) | 2017-02-27 | 2018-02-26 | Use of biomarkers in identifying cancer patients that will be responsive to treatment with a prmt5 inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019010150A true MX2019010150A (es) | 2019-10-21 |
Family
ID=61563368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019010150A MX2019010150A (es) | 2017-02-27 | 2018-02-26 | Uso de biomarcadores en la identificacion de pacientes con cancer que seran sensibles al tratamiento con un inhibidor de prmt5. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US11279970B2 (es) |
| EP (1) | EP3585904B1 (es) |
| JP (1) | JP7225106B2 (es) |
| KR (1) | KR102573149B1 (es) |
| CN (1) | CN110382707A (es) |
| AU (1) | AU2018225312B2 (es) |
| BR (1) | BR112019017466A2 (es) |
| CA (1) | CA3049739A1 (es) |
| CL (1) | CL2019002438A1 (es) |
| CO (1) | CO2019008390A2 (es) |
| EA (1) | EA201992026A1 (es) |
| ES (1) | ES2971035T3 (es) |
| IL (1) | IL268842B2 (es) |
| JO (1) | JOP20190199B1 (es) |
| MA (1) | MA47594A (es) |
| MX (1) | MX2019010150A (es) |
| MY (1) | MY195860A (es) |
| PE (1) | PE20191359A1 (es) |
| PH (1) | PH12019501942A1 (es) |
| SG (1) | SG11201907607VA (es) |
| TN (1) | TN2019000212A1 (es) |
| UA (1) | UA127679C2 (es) |
| WO (1) | WO2018154104A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI791251B (zh) | 2015-08-26 | 2023-02-01 | 比利時商健生藥品公司 | 使用作為ｐｒｍｔ５抑制劑之新穎經６-６雙環芳香環取代之核苷類似物 |
| UA123637C2 (uk) | 2016-03-10 | 2021-05-05 | Янссен Фармацевтика Нв | Заміщені аналоги нуклеозидів для застосування як інгібіторів prmt5 |
| EP3519413A1 (en) | 2016-10-03 | 2019-08-07 | Janssen Pharmaceutica NV | Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors |
| BR112019017466A2 (pt) | 2017-02-27 | 2020-03-31 | Janssen Pharmaceutica Nv | Uso de biomarcadores na identificação de pacientes com câncer que serão responsivos a tratamento com um inibidor de prmt5 |
| AU2018381004B2 (en) * | 2017-12-05 | 2021-04-29 | Angex Pharmaceutical, Inc. | Heterocyclic compounds as PRMT5 inhibitors |
| IL275129B2 (en) | 2017-12-08 | 2023-10-01 | Janssen Pharmaceutica Nv | Novel spirobicyclic analogues |
| IL262658A (en) * | 2018-10-28 | 2020-04-30 | Memorial Sloan Kettering Cancer Center | Prevention of age related clonal hematopoiesis and diseases associated therewith |
| US11198699B2 (en) | 2019-04-02 | 2021-12-14 | Aligos Therapeutics, Inc. | Compounds targeting PRMT5 |
| GB201905780D0 (en) | 2019-04-25 | 2019-06-05 | La Thangue Nicholas | Cancer therapy |
| TW202112375A (zh) | 2019-06-06 | 2021-04-01 | 比利時商健生藥品公司 | 使用ｐｒｍｔ５抑制劑治療癌症之方法 |
| CN120539415A (zh) * | 2024-02-21 | 2025-08-26 | 复旦大学附属华山医院 | 一种系统性硬化症生物标志物及其检测方法与应用 |
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| US6143749A (en) | 1995-06-07 | 2000-11-07 | Abbott Laboratories | Heterocyclic substituted cyclopentane compounds |
| CN1331326A (zh) * | 2000-06-30 | 2002-01-16 | 上海博德基因开发有限公司 | 一种新的多肽——人精氨酸甲基转移酶(hrmt)32.12和编码这种多肽的多核苷酸 |
| WO2003039523A2 (en) | 2001-11-05 | 2003-05-15 | Exiqon A/S | OLIGONUCLEOTIDES MODIFIED WITH NOVEL α-L-RNA ANALOGUES |
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| AU2002951247A0 (en) | 2002-09-06 | 2002-09-19 | Alchemia Limited | Compounds that interact with kinases |
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| US8323918B2 (en) * | 2008-12-12 | 2012-12-04 | University Of South Carolina | Chloroacetamidine based inhibitors and activity based probes for the protein arginine methytransferases |
| BR112012014925A2 (pt) | 2009-12-18 | 2017-03-01 | Joslin Diabetes Center Inc | compostos promotores de replicação de células beta e métodos de uso dos mesmos |
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| EP2771012A4 (en) | 2011-10-24 | 2015-06-24 | Glaxosmithkline Ip No 2 Ltd | NEW CONNECTIONS |
| WO2013151975A1 (en) | 2012-04-02 | 2013-10-10 | Northeastern University | Compositions and methods for the inhibition of methyltransferases |
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| JP2016505001A (ja) * | 2012-12-21 | 2016-02-18 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
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| JP6510485B2 (ja) | 2013-03-15 | 2019-05-08 | オハイオ・ステイト・イノベーション・ファウンデーション | Ｐｒｍｔ５インヒビターおよびそれらの使用方法 |
| EP3091984B1 (en) | 2014-01-09 | 2020-04-22 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Substituted benzoxazine and related compounds |
| WO2015200680A2 (en) | 2014-06-25 | 2015-12-30 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| MX376054B (es) | 2014-07-01 | 2025-03-07 | Takeda Pharmaceuticals Co | Compuestos de heteroarilo utiles como inhibidores de enzima activadora de sumo. |
| EA031895B1 (ru) | 2015-02-24 | 2019-03-29 | Пфайзер Инк. | Замещенные нуклеозидные производные, полезные в качестве агентов против рака |
| TWI791251B (zh) | 2015-08-26 | 2023-02-01 | 比利時商健生藥品公司 | 使用作為ｐｒｍｔ５抑制劑之新穎經６-６雙環芳香環取代之核苷類似物 |
| CN108884108B (zh) | 2016-03-10 | 2021-08-31 | 詹森药业有限公司 | 用于用作prmt5抑制剂的取代核苷类似物 |
| WO2018065365A1 (en) | 2016-10-03 | 2018-04-12 | Janssen Pharmaceutica Nv | Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors |
| EP3519413A1 (en) | 2016-10-03 | 2019-08-07 | Janssen Pharmaceutica NV | Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors |
| BR112019017466A2 (pt) | 2017-02-27 | 2020-03-31 | Janssen Pharmaceutica Nv | Uso de biomarcadores na identificação de pacientes com câncer que serão responsivos a tratamento com um inibidor de prmt5 |
| IL275129B2 (en) | 2017-12-08 | 2023-10-01 | Janssen Pharmaceutica Nv | Novel spirobicyclic analogues |
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2018
- 2018-02-26 BR BR112019017466-4A patent/BR112019017466A2/pt not_active Application Discontinuation
- 2018-02-26 MX MX2019010150A patent/MX2019010150A/es unknown
- 2018-02-26 PE PE2019001538A patent/PE20191359A1/es unknown
- 2018-02-26 CN CN201880013998.5A patent/CN110382707A/zh active Pending
- 2018-02-26 UA UAA201910005A patent/UA127679C2/uk unknown
- 2018-02-26 WO PCT/EP2018/054644 patent/WO2018154104A1/en not_active Ceased
- 2018-02-26 AU AU2018225312A patent/AU2018225312B2/en not_active Ceased
- 2018-02-26 EP EP18708634.3A patent/EP3585904B1/en active Active
- 2018-02-26 TN TNP/2019/000212A patent/TN2019000212A1/en unknown
- 2018-02-26 JO JOP/2019/0199A patent/JOP20190199B1/ar active
- 2018-02-26 ES ES18708634T patent/ES2971035T3/es active Active
- 2018-02-26 CA CA3049739A patent/CA3049739A1/en active Pending
- 2018-02-26 MA MA047594A patent/MA47594A/fr unknown
- 2018-02-26 SG SG11201907607VA patent/SG11201907607VA/en unknown
- 2018-02-26 IL IL268842A patent/IL268842B2/en unknown
- 2018-02-26 EA EA201992026A patent/EA201992026A1/ru unknown
- 2018-02-26 US US16/487,852 patent/US11279970B2/en active Active
- 2018-02-26 KR KR1020197024211A patent/KR102573149B1/ko active Active
- 2018-02-26 JP JP2019545251A patent/JP7225106B2/ja active Active
- 2018-02-26 MY MYPI2019004748A patent/MY195860A/en unknown
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2019
- 2019-07-31 CO CONC2019/0008390A patent/CO2019008390A2/es unknown
- 2019-08-22 PH PH12019501942A patent/PH12019501942A1/en unknown
- 2019-08-23 CL CL2019002438A patent/CL2019002438A1/es unknown
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2022
- 2022-02-10 US US17/669,008 patent/US11999993B2/en active Active
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