[go: up one dir, main page]

MX2019009839A - Celulas eritroides funcionalizadas. - Google Patents

Celulas eritroides funcionalizadas.

Info

Publication number
MX2019009839A
MX2019009839A MX2019009839A MX2019009839A MX2019009839A MX 2019009839 A MX2019009839 A MX 2019009839A MX 2019009839 A MX2019009839 A MX 2019009839A MX 2019009839 A MX2019009839 A MX 2019009839A MX 2019009839 A MX2019009839 A MX 2019009839A
Authority
MX
Mexico
Prior art keywords
erythroid cells
functionalized
functionalized erythroid
reagents
methods
Prior art date
Application number
MX2019009839A
Other languages
English (en)
Inventor
Mata-Fink Jordi
F Chen Tiffany
Wickham Tom
Elloul Sivan
Zhang Xuqing
Hudak Carolyn
Law Billy
Hoffman Lenka
Eric TEICHERT Kristian
Rabia Dastagir Shamael
Original Assignee
Rubius Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rubius Therapeutics Inc filed Critical Rubius Therapeutics Inc
Publication of MX2019009839A publication Critical patent/MX2019009839A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0641—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

En el presente documento se describen nuevas preparaciones de células eritroides funcionalizadas y composiciones, reactivos y métodos relacionados para su uso en aplicaciones farmacéuticas y veterinarias.
MX2019009839A 2017-02-17 2018-02-16 Celulas eritroides funcionalizadas. MX2019009839A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762460589P 2017-02-17 2017-02-17
US201762542142P 2017-08-07 2017-08-07
PCT/US2018/000042 WO2018151829A1 (en) 2017-02-17 2018-02-16 Functionalized erythroid cells

Publications (1)

Publication Number Publication Date
MX2019009839A true MX2019009839A (es) 2019-10-22

Family

ID=61873874

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019009839A MX2019009839A (es) 2017-02-17 2018-02-16 Celulas eritroides funcionalizadas.

Country Status (12)

Country Link
US (2) US11020435B2 (es)
EP (1) EP3583202A1 (es)
JP (1) JP2020507329A (es)
KR (1) KR20190117667A (es)
CN (1) CN110520522A (es)
AU (1) AU2018221227A1 (es)
BR (1) BR112019016951A2 (es)
CA (1) CA3052142A1 (es)
IL (1) IL268359A (es)
MX (1) MX2019009839A (es)
SG (1) SG11201906933SA (es)
WO (1) WO2018151829A1 (es)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2930665A1 (en) 2013-11-18 2015-05-21 Rubius Therapeutics, Inc. Synthetic membrane-receiver complexes
PL3125927T3 (pl) 2014-04-01 2021-07-19 Rubius Therapeutics, Inc. Sposoby i kompozycje do immunomodulacji
CN108778298A (zh) 2016-01-11 2018-11-09 鲁比厄斯治疗法股份有限公司 与免疫适应症的多模式治疗性细胞体系有关的组合物和方法
KR20190117667A (ko) * 2017-02-17 2019-10-16 루비우스 테라퓨틱스, 아이엔씨. 기능화된 적혈구 세포
WO2019090148A2 (en) 2017-11-03 2019-05-09 Rubius Therapeutics, Inc. Compositions and methods related to therapeutic cell systems for tumor growth inhibition
AU2018389346B2 (en) * 2017-12-23 2022-08-25 Rubius Therapeutics, Inc. Artificial antigen presenting cells and methods of use
WO2019140116A2 (en) 2018-01-10 2019-07-18 Rubius Therapeutics, Inc. Amplifiable rnas for therapeutic cell systems
RU2020132924A (ru) 2018-03-08 2022-04-11 Рубиус Терапьютикс, Инк. Терапевтические клеточные системы и способы лечения рака и инфекционных заболеваний
US11166996B2 (en) 2018-12-12 2021-11-09 Flagship Pioneering Innovations V, Inc. Anellovirus compositions and methods of use
BR112021013934A2 (pt) 2019-01-18 2021-09-21 Flagship Pioneering, Inc. Composições de trem e seus usos
EP3927354A1 (en) 2019-02-20 2021-12-29 Rubius Therapeutics, Inc. Engineered erythroid cells including loadable antigen-presenting polypeptides and methods of use
CN121081490A (zh) 2019-03-04 2025-12-09 旗舰创业创新第六有限责任公司 环状多核糖核苷酸及其药物组合物
CA3131319A1 (en) 2019-03-25 2020-10-01 Avak Kahvejian Compositions comprising modified circular polyribonucleotides and uses thereof
JP2022534988A (ja) 2019-05-31 2022-08-04 フラッグシップ パイオニアリング， インコーポレイテッド ｔＲＮＡプールを調節するためのＴＲＥＭの使用
US20220257794A1 (en) 2019-06-14 2022-08-18 Flagship Pioneering Innovations Vi, Llc Circular rnas for cellular therapy
WO2020257730A1 (en) 2019-06-19 2020-12-24 Flagship Pioneering Innovations Vi, Llc Compositions comprising circular polyribonucleotides for protein modulation and uses thereof
CA3160097A1 (en) 2019-11-04 2021-05-14 Flagship Pioneering, Inc. Trem compositions for con-rare codons and related uses
EP4055169A1 (en) 2019-11-04 2022-09-14 Flagship Pioneering, Inc. Methods of modifying a nucleic acid sequence
TW202142239A (zh) 2020-01-29 2021-11-16 美商旗艦先鋒創新有限責任公司 包含環狀多核糖核苷酸之組合物之遞送
WO2021155175A1 (en) 2020-01-29 2021-08-05 Flagship Pioneering Innovations Vi, Llc Compositions for translation and methods of use thereof
US20230340451A1 (en) 2020-01-29 2023-10-26 Flagship Pioneering Innovations Vi, Llc Compositions comprising linear polyribonucleotides for protein modulation and uses thereof
CN115151636A (zh) * 2020-02-10 2022-10-04 鲁比厄斯治疗法股份有限公司 包含hla-g多肽的经工程改造的红系细胞及其使用方法
CN115335064B (zh) * 2020-03-20 2024-08-30 西湖生物医药科技(杭州)有限公司 修饰的红细胞及其用于递送药剂的用途
US20230193311A1 (en) 2020-05-20 2023-06-22 Flagship Pioneering Innovations Vi, Llc Immunogenic compositions and uses thereof
US20230203192A1 (en) 2020-05-20 2023-06-29 Flagship Pioneering, Inc. Compositions and methods for producing human polyclonal antibodies
MX2022014653A (es) 2020-05-20 2023-02-16 Flagship Pioneering Innovations Vi Llc Composiciones de antigeno de coronavirus y sus usos.
IL298539A (en) 2020-05-29 2023-01-01 Flagship Pioneering Innovations Vi Llc Trem compositions and methods relating thereto
CA3182026A1 (en) 2020-05-29 2021-12-02 Flagship Pioneering Innovations Vi, Llc. Trem compositions and methods relating thereto
US20230233514A1 (en) 2020-06-23 2023-07-27 Flagship Pioneering, Inc. Antiviral compounds and methods of using the same
JP2023542492A (ja) 2020-09-03 2023-10-10 フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー 免疫原性組成物及びその使用
WO2022140702A1 (en) 2020-12-23 2022-06-30 Flagship Pioneering, Inc. Compositions of modified trems and uses thereof
AU2022246895A1 (en) 2021-03-31 2023-10-19 Flagship Pioneering Innovations V, Inc. Thanotransmission polypeptides and their use in treating cancer
WO2023284742A1 (en) * 2021-07-13 2023-01-19 Westlake Therapeutics (Hangzhou) Co. Limited Cells modified by conjugated n-terminal glycine and uses thereof
EP4377457A1 (en) 2021-07-26 2024-06-05 Flagship Pioneering Innovations VI, LLC Trem compositions and uses thereof
WO2023044006A1 (en) 2021-09-17 2023-03-23 Flagship Pioneering Innovations Vi, Llc Compositions and methods for producing circular polyribonucleotides
KR20240126857A (ko) 2021-10-18 2024-08-21 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 폴리리보뉴클레오티드를 정제하기 위한 조성물 및 방법
WO2023097003A2 (en) 2021-11-24 2023-06-01 Flagship Pioneering Innovations Vi, Llc Immunogenic compositions and their uses
CA3239266A1 (en) 2021-11-24 2023-06-01 Flagship Pioneering Innovations Vi, Llc Coronavirus immunogen compositions and their uses
JP2024541466A (ja) 2021-11-24 2024-11-08 フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー 水痘帯状疱疹ウイルス免疫原組成物及びその使用
CN118679254A (zh) 2021-12-22 2024-09-20 旗舰创业创新六公司 用于纯化多核糖核苷酸的组合物和方法
CA3241026A1 (en) 2021-12-23 2023-06-29 Flagship Pioneering Innovations Vi, Llc Circular polyribonucleotides encoding antifusogenic polypeptides
WO2023196593A1 (en) * 2022-04-08 2023-10-12 The University Of North Carolina At Chapel Hill Antigen-independent targeted delivery of therapeutic agents
CA3257006A1 (en) 2022-05-09 2023-11-16 Flagship Pioneering Innovations Vi, Llc TREM COMPOSITIONS AND METHODS OF USE FOR TREATING PROLIFERATIVE DISORDERS
EP4522753A2 (en) 2022-05-13 2025-03-19 Flagship Pioneering Innovations VII, LLC Double stranded dna compositions and related methods
WO2023230566A2 (en) 2022-05-25 2023-11-30 Flagship Pioneering Innovations Vii, Llc Compositions and methods for modulating cytokines
KR20250019668A (ko) 2022-05-25 2025-02-10 플래그쉽 파이어니어링 이노베이션스 Vii, 엘엘씨 순환 인자를 조절하기 위한 조성물 및 방법
KR20250019772A (ko) 2022-05-25 2025-02-11 플래그쉽 파이어니어링 이노베이션스 Vii, 엘엘씨 종양 억제인자 및 발암유전자를 조절하기 위한 조성물 및 방법
JP2025519096A (ja) 2022-05-25 2025-06-24 フラッグシップ パイオニアリング イノベーションズ セブン，エルエルシー 遺伝的ドライバーを調節するための組成物及び方法
JP2025517968A (ja) 2022-05-25 2025-06-12 フラッグシップ パイオニアリング イノベーションズ セブン，エルエルシー 免疫応答を調節するための組成物及び方法
US20250179492A1 (en) 2022-06-22 2025-06-05 Flagship Pioneering Innovations Vi, Llc Compositions of modified trems and uses thereof
EP4598946A1 (en) 2022-10-05 2025-08-13 Flagship Pioneering Innovations V, Inc. Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer
KR20250099195A (ko) 2022-10-31 2025-07-01 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 폴리리보뉴클레오티드를 정제하기 위한 조성물 및 방법
CN120435298A (zh) 2022-11-08 2025-08-05 旗舰创业创新第六有限责任公司 用于产生环状多核糖核苷酸的组合物和方法
TW202430215A (zh) 2022-12-14 2024-08-01 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 用於將治療劑遞送至骨之組成物和方法
US20240238473A1 (en) 2023-01-09 2024-07-18 Beth Israel Deaconess Medical Center, Inc. Recombinant nucleic acid molecules and their use in wound healing
WO2024151685A1 (en) 2023-01-09 2024-07-18 Beth Israel Deaconess Medical Center, Inc. Recombinant nucleic acid molecules and their use in wound healing
US20240269251A1 (en) 2023-01-09 2024-08-15 Flagship Pioneering Innovations V, Inc. Genetic switches and their use in treating cancer
WO2024173836A2 (en) 2023-02-17 2024-08-22 Flagship Pioneering Innovations Vii, Llc Dna compositions comprising modified cytosine
TW202438089A (zh) 2023-02-17 2024-10-01 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 包含經修飾的尿嘧啶的ｄｎａ組成物
CN121358494A (zh) 2023-03-15 2026-01-16 旗舰创业创新第六有限责任公司 免疫原性组合物及其用途
CN121127594A (zh) 2023-03-15 2025-12-12 旗舰创业创新第六有限责任公司 包含多核糖核苷酸的组合物及其用途
KR20250171373A (ko) 2023-04-12 2025-12-08 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 미스센스 돌연변이 교정용 trem
WO2025006684A1 (en) 2023-06-28 2025-01-02 Flagship Pioneering Innovations Vi, Llc Circular polyribonucleotides encoding antifusogenic polypeptides
WO2025042786A1 (en) 2023-08-18 2025-02-27 Flagship Pioneering Innovations Vi, Llc Compositions comprising circular polyribonucleotides and uses thereof
WO2025096807A2 (en) 2023-10-31 2025-05-08 Flagship Pioneering Innovations Vii, Llc Novel therapeutic dna forms
WO2025124492A1 (zh) * 2023-12-13 2025-06-19 西湖生物医药科技(上海)有限公司 修饰的红细胞
US20260000702A1 (en) 2024-06-26 2026-01-01 Flagship Pioneering Innovations Vii, Llc Therapeutic circular dna forms

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070243137A1 (en) 2006-04-18 2007-10-18 Nanoprobes, Inc. Cell and sub-cell methods for imaging and therapy
US8501478B2 (en) 2006-06-15 2013-08-06 University Of Cincinnati Trehalose click polymers for delivery of biologically active molecules
KR20090094812A (ko) 2006-10-18 2009-09-08 더 스크립스 리서치 인스티튜트 포유동물 세포에서 비천연 아미노산의 단백질 내로의 유전적 도입
EP2057998A1 (en) 2007-10-31 2009-05-13 Universitätsklinikum Hamburg-Eppendorf Use of modified cells for the treatment of multiple sclerosis
KR20210003301A (ko) * 2008-05-06 2021-01-11 아스텔라스 인스티튜트 포 리제너러티브 메디슨 다능성 줄기세포로부터 유도된 탈핵 적혈구계 세포를 생산하는 방법
US20110092961A1 (en) 2008-08-13 2011-04-21 Searete Llc Artificial cells
US20100040546A1 (en) 2008-08-13 2010-02-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Biological targeting compositions and methods of using the same
US8968818B2 (en) 2009-02-21 2015-03-03 Covidien Lp Medical devices having activated surfaces
US8912323B2 (en) 2009-10-30 2014-12-16 The Regents Of The University Of Michigan Multifunctional small molecules
CA2758390A1 (en) * 2011-11-14 2013-05-14 Ibc Pharmaceuticals, Inc. Stem cell targeting with dock-and-lock (dnl) complexes
EP4052717A1 (en) 2012-03-13 2022-09-07 Celularity Inc. Modified erythrocyte precursor cells and uses thereof
FR2997082B1 (fr) 2012-10-18 2015-02-13 Centre Nat Rech Scient Reactifs de couplage multifonctionnels a fonction azlactone.
WO2014183071A2 (en) * 2013-05-10 2014-11-13 Whitehead Institute For Biomedical Research In vitro production of red blood cells with sortaggable proteins
WO2014183066A2 (en) 2013-05-10 2014-11-13 Whitehead Institute For Biomedical Research Protein modification of living cells using sortase
JP2015032986A (ja) 2013-08-02 2015-02-16 住友電気工業株式会社 無線端末装置、無線基地局装置、通信システム、無線アクセス提供方法および通信制御プログラム
CA2930665A1 (en) 2013-11-18 2015-05-21 Rubius Therapeutics, Inc. Synthetic membrane-receiver complexes
PL3125927T3 (pl) * 2014-04-01 2021-07-19 Rubius Therapeutics, Inc. Sposoby i kompozycje do immunomodulacji
US10053683B2 (en) 2014-10-03 2018-08-21 Whitehead Institute For Biomedical Research Intercellular labeling of ligand-receptor interactions
US20180110831A1 (en) 2015-03-09 2018-04-26 Stc.Unm Cd 47 containing porous nanoparticle supported lipid bilayers (protocells) field of the invention
WO2016183482A1 (en) * 2015-05-13 2016-11-17 Rubius Therapeutics, Inc. Membrane-receiver complex therapeutics
CN108778298A (zh) 2016-01-11 2018-11-09 鲁比厄斯治疗法股份有限公司 与免疫适应症的多模式治疗性细胞体系有关的组合物和方法
US11371019B2 (en) 2016-03-04 2022-06-28 Whitehead Institute For Biomedical Research Efficient generation of human red blood cells via enriching peripheral blood erythroid progenitors
US20190161730A1 (en) 2016-07-07 2019-05-30 Rubius Therapeutics, Inc. Compositions and methods related to therapeutic cell systems expressing exogenous rna
KR20190091497A (ko) 2016-12-02 2019-08-06 루비우스 테라퓨틱스, 아이엔씨. 고형 종양으로의 침투를 위한 세포 시스템과 관련된 조성물 및 방법
KR20190117667A (ko) * 2017-02-17 2019-10-16 루비우스 테라퓨틱스, 아이엔씨. 기능화된 적혈구 세포
EP4328314A3 (en) * 2017-08-22 2024-03-20 Tessera Therapeutics, Inc. Lipid nanoparticle methods and compositions for producing engineered erythroid cells
WO2019090148A2 (en) * 2017-11-03 2019-05-09 Rubius Therapeutics, Inc. Compositions and methods related to therapeutic cell systems for tumor growth inhibition
US20190201548A1 (en) 2017-12-29 2019-07-04 Rubius Therapeutics, Inc. Gene editing and targeted transcriptional modulation for engineering erythroid cells
WO2019140116A2 (en) 2018-01-10 2019-07-18 Rubius Therapeutics, Inc. Amplifiable rnas for therapeutic cell systems
CA3121258A1 (en) * 2018-12-03 2020-06-11 Rubius Therapeutics, Inc. Artificial antigen presenting cells including hla-e and hla-g molecules and methods of use
EP3927354A1 (en) * 2019-02-20 2021-12-29 Rubius Therapeutics, Inc. Engineered erythroid cells including loadable antigen-presenting polypeptides and methods of use
KR20220005028A (ko) * 2019-04-26 2022-01-12 루비우스 테라퓨틱스, 아이엔씨. 탈핵 적혈구를 포함하는 조성물
CA3141315A1 (en) * 2019-05-24 2020-12-03 Rubius Therapeutics, Inc. Methods of generating enucleated erythroid cells
CN115151636A (zh) * 2020-02-10 2022-10-04 鲁比厄斯治疗法股份有限公司 包含hla-g多肽的经工程改造的红系细胞及其使用方法

Also Published As

Publication number Publication date
WO2018151829A1 (en) 2018-08-23
US20210290682A1 (en) 2021-09-23
CA3052142A1 (en) 2018-08-23
CN110520522A (zh) 2019-11-29
KR20190117667A (ko) 2019-10-16
IL268359A (en) 2019-09-26
RU2019129088A3 (es) 2021-03-25
AU2018221227A1 (en) 2019-08-15
EP3583202A1 (en) 2019-12-25
US11020435B2 (en) 2021-06-01
BR112019016951A2 (pt) 2020-05-26
JP2020507329A (ja) 2020-03-12
US20180344770A1 (en) 2018-12-06
SG11201906933SA (en) 2019-09-27
RU2019129088A (ru) 2021-03-17

Similar Documents

Publication Publication Date Title
MX2019009839A (es) Celulas eritroides funcionalizadas.
PH12020551716A1 (en) Anti-ror antibody constructs
MX2024014843A (es) Proteinas de union a antigenos de maduracion de celulas b
MX2020001555A (es) Preparaciones terapéuticas de glicanos y métodos relacionados con estas.
MX421186B (es) Constructos de anticuerpos.
MX2019006043A (es) Proteína de unión de antígeno prostático específico de membrana.
ZA201906011B (en) Apoptosis-inducing agents
MX2019008413A (es) Celulas pluripotentes inmunodiseñadas.
PH12017500803A1 (en) Anti-pd-1 antibodies
BR112016022814A8 (pt) composição farmacêutica e seu método de preparação, ácido nucleico, e dispositivo médico ou kit médico
PH12019500571A1 (en) Anti-pd-1 antibodies
PH12019501872A1 (en) Anti-tryptase antibodies, compositions thereof, and uses thereof
MX2019002699A (es) Terapia genica para pacientes con anemia de fanconi.
AR106385A1 (es) Composición cosmética que comprende bacterias probióticas
WO2020028269A3 (en) Multispecific treg binding molecules
SG10201805646WA (en) Angiopoietin-like 4 antibodies and methods of use
MX393281B (es) Conjugados y composiciones de texafirina-pt (iv) para su uso para superar la resistencia del platino.
PH12020550483A1 (en) Anti-apoc3 antibodies and methods of use thereof
PH12020550217A1 (en) Nutrient-spore formulations and uses thereof
TW201613977A (en) Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use
MX2020013389A (es) Composiciones de terlipresina y usos de las mismas.
PH12018502139A1 (en) Phosphaplatin liquid formulations
EA202091403A1 (ru) Производные 2-оксо-1-пирролидинилимидазотиадиазола
MX2020005948A (es) Complejos de zinc-aminoacido-tripolifosfato.
AR106716A1 (es) Anticuerpos anti-factor d y conjugados