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MX2019009283A - Composiciones de arni de proteina convertasa subtilisina kexina 9 (pcsk9) y metodos de uso de las mismas. - Google Patents

Composiciones de arni de proteina convertasa subtilisina kexina 9 (pcsk9) y metodos de uso de las mismas.

Info

Publication number
MX2019009283A
MX2019009283A MX2019009283A MX2019009283A MX2019009283A MX 2019009283 A MX2019009283 A MX 2019009283A MX 2019009283 A MX2019009283 A MX 2019009283A MX 2019009283 A MX2019009283 A MX 2019009283A MX 2019009283 A MX2019009283 A MX 2019009283A
Authority
MX
Mexico
Prior art keywords
methods
pcsk9
irna compositions
rnai agents
pcsk9 irna
Prior art date
Application number
MX2019009283A
Other languages
English (en)
Inventor
Fitzgerald Kevin
Milstein Stuart
Querbes William
Frank-Kamenetsky Maria
Maier Martin
Kuchimanchi Satyanarayana
Charisse Klaus
Borodovsky Anna
G Kallanthottathil Rajeev
Manoharan Muthiah
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49841845&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2019009283(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2019009283A publication Critical patent/MX2019009283A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3533—Halogen
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen

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  • Bioinformatics & Cheminformatics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

La invención se refiere a agentes de iARN, por ejemplo, agentes de iARN bicatenario, que se dirigen al gen PCSK9, y a métodos de uso de tales agentes de iARN para inhibir la expresión de PCSK9 y métodos para tratar sujetos que tienen un trastorno de lípidos, tal como una hiperlipidemia.
MX2019009283A 2012-12-05 2015-06-03 Composiciones de arni de proteina convertasa subtilisina kexina 9 (pcsk9) y metodos de uso de las mismas. MX2019009283A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261733518P 2012-12-05 2012-12-05
US201361793530P 2013-03-15 2013-03-15
US201361886916P 2013-10-04 2013-10-04
US201361892188P 2013-10-17 2013-10-17

Publications (1)

Publication Number Publication Date
MX2019009283A true MX2019009283A (es) 2019-12-11

Family

ID=49841845

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015007035A MX367076B (es) 2012-12-05 2013-12-05 Composiciones de arni de proteina convertasa subtilisina kexina 9 (pcsk9) y metodos de uso de las mismas.
MX2019009283A MX2019009283A (es) 2012-12-05 2015-06-03 Composiciones de arni de proteina convertasa subtilisina kexina 9 (pcsk9) y metodos de uso de las mismas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015007035A MX367076B (es) 2012-12-05 2013-12-05 Composiciones de arni de proteina convertasa subtilisina kexina 9 (pcsk9) y metodos de uso de las mismas.

Country Status (30)

Country Link
US (2) US10125369B2 (es)
EP (3) EP2929031B9 (es)
JP (5) JP6574383B2 (es)
KR (2) KR102096014B1 (es)
CN (2) CN108220295B (es)
AR (1) AR093835A1 (es)
AU (4) AU2013355237C1 (es)
BR (1) BR112015013105B1 (es)
CA (1) CA2892160C (es)
CY (2) CY1120195T1 (es)
DK (1) DK2929031T5 (es)
ES (1) ES2657608T3 (es)
FR (1) FR21C1021I2 (es)
HK (1) HK1256621A1 (es)
HR (1) HRP20180126T2 (es)
HU (2) HUE035887T2 (es)
IL (2) IL238917B (es)
LT (2) LT2929031T (es)
LU (1) LUC00209I2 (es)
MX (2) MX367076B (es)
NL (1) NL301107I2 (es)
NO (1) NO2021024I1 (es)
NZ (1) NZ709013A (es)
PL (1) PL2929031T4 (es)
PT (1) PT2929031T (es)
RS (1) RS56783B9 (es)
SI (1) SI2929031T1 (es)
SM (1) SMT201800039T1 (es)
WO (1) WO2014089313A1 (es)
ZA (1) ZA201503829B (es)

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