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MX2019004573A - Metodos para evitar eventos cardiovasculares mediante la reduccion de la proproteinas convertasa subtilisina kexina 9 (pcsk9). - Google Patents

Metodos para evitar eventos cardiovasculares mediante la reduccion de la proproteinas convertasa subtilisina kexina 9 (pcsk9).

Info

Publication number
MX2019004573A
MX2019004573A MX2019004573A MX2019004573A MX2019004573A MX 2019004573 A MX2019004573 A MX 2019004573A MX 2019004573 A MX2019004573 A MX 2019004573A MX 2019004573 A MX2019004573 A MX 2019004573A MX 2019004573 A MX2019004573 A MX 2019004573A
Authority
MX
Mexico
Prior art keywords
subject
cardiovascular disease
pcsk9
methods
atherosclerotic cardiovascular
Prior art date
Application number
MX2019004573A
Other languages
English (en)
Inventor
Wijngaard Peter
Kallend David
Original Assignee
The Medicines Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60388127&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2019004573(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Medicines Co filed Critical The Medicines Co
Publication of MX2019004573A publication Critical patent/MX2019004573A/es

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21061Kexin (3.4.21.61), i.e. proprotein convertase subtilisin/kexin type 9
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
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    • C12N2310/3515Lipophilic moiety, e.g. cholesterol
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    • C12N2310/30Chemical structure
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/353Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533Halogen

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)

Abstract

Método para reducir el colesterol de lipoproteínas de baja densidad o prevenir un evento cardíaco en un sujeto que tiene enfermedad cardiovascular aterosclerótica o que está en riesgo de padecer enfermedad cardiovascular aterosclerótica equivalente, que implica administrar al sujeto una cantidad profilácticamente efectiva de un agente de ARNi. Además, un método para prevenir el desarrollo de enfermedad cardiovascular aterosclerótica en un sujeto que implica administrar al sujeto una cantidad profilácticamente efectiva de un agente de ARNi. Además, un método para tratar a un sujeto que tiene enfermedad cardiovascular aterosclerótica o que está en riesgo de enfermedad cardiovascular aterosclerótica equivalente, que implica la administración al sujeto de una cantidad terapéuticamente efectiva de un agente de ARNi.
MX2019004573A 2016-10-18 2017-10-18 Metodos para evitar eventos cardiovasculares mediante la reduccion de la proproteinas convertasa subtilisina kexina 9 (pcsk9). MX2019004573A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662409816P 2016-10-18 2016-10-18
US201662422028P 2016-11-14 2016-11-14
US201762472525P 2017-03-16 2017-03-16
US201762550426P 2017-08-25 2017-08-25
PCT/US2017/057218 WO2018075658A1 (en) 2016-10-18 2017-10-18 Methods for preventing cardiovascular events through proprotein convertase subtilisin kexin 9 (pcsk9) protein reduction

Publications (1)

Publication Number Publication Date
MX2019004573A true MX2019004573A (es) 2019-10-07

Family

ID=60388127

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019004573A MX2019004573A (es) 2016-10-18 2017-10-18 Metodos para evitar eventos cardiovasculares mediante la reduccion de la proproteinas convertasa subtilisina kexina 9 (pcsk9).
MX2024004495A MX2024004495A (es) 2016-10-18 2019-04-17 Agentes de acidos ribonucleicos de interferencia para usarse en la prevencion de eventos cardiovasculares.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2024004495A MX2024004495A (es) 2016-10-18 2019-04-17 Agentes de acidos ribonucleicos de interferencia para usarse en la prevencion de eventos cardiovasculares.

Country Status (22)

Country Link
US (2) US20180104360A1 (es)
EP (2) EP3529360B1 (es)
JP (3) JP7181881B2 (es)
KR (3) KR20240067272A (es)
CN (4) CN110088283A (es)
AU (2) AU2017346879B2 (es)
BR (1) BR112019007843A2 (es)
CA (1) CA3042423A1 (es)
CL (1) CL2019001047A1 (es)
DK (1) DK3529360T3 (es)
ES (1) ES2982911T3 (es)
FI (1) FI3529360T3 (es)
HR (1) HRP20240930T1 (es)
HU (1) HUE067712T2 (es)
IL (1) IL266066A (es)
LT (1) LT3529360T (es)
MX (2) MX2019004573A (es)
PL (1) PL3529360T3 (es)
PT (1) PT3529360T (es)
RS (1) RS65725B1 (es)
SI (1) SI3529360T1 (es)
WO (1) WO2018075658A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2892160C (en) 2012-12-05 2021-03-23 Anna Borodovsky Pcsk9 irna compositions and methods of use thereof
MX2018002158A (es) 2015-08-25 2018-07-06 Alnylam Pharmaceuticals Inc Mí‰TODOS Y COMPOSICIONES PARA TRATAR UN TRASTORNO ASOCIADO A GEN DE PROPROTEINA CONVERTASA SUBTILISINA KEXINA (PCSK9).
MX2019004573A (es) 2016-10-18 2019-10-07 The Medicines Co Metodos para evitar eventos cardiovasculares mediante la reduccion de la proproteinas convertasa subtilisina kexina 9 (pcsk9).
EP3645546A4 (en) 2017-06-30 2021-12-01 Solstice Biologics, Ltd. CHIRAL PHOSPHORAMIDITIS AUXILIARIES AND THEIR METHODS OF USE
EP4455285A3 (en) 2017-12-01 2025-02-26 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof
WO2019105414A1 (zh) 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
US11660347B2 (en) 2017-12-01 2023-05-30 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate containing same, preparation method, and use thereof
CN110944675B9 (zh) 2017-12-01 2024-08-09 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
WO2019105418A1 (zh) 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途
JP7436030B2 (ja) 2017-12-29 2024-02-21 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 複合体及びその調製方法と使用
CN111655849B (zh) 2018-08-21 2024-05-10 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的药物组合物和缀合物及其用途
CN111655297A (zh) 2018-09-30 2020-09-11 苏州瑞博生物技术有限公司 一种siRNA缀合物及其制备方法和用途
CN112423794A (zh) 2018-12-28 2021-02-26 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
CN117701564A (zh) * 2019-05-22 2024-03-15 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
TW202517786A (zh) 2019-05-22 2025-05-01 大陸商蘇州瑞博生物技術股份有限公司 核酸、包含其的藥物組合物和綴合物及其用途
EP4081642A1 (en) 2020-03-16 2022-11-02 Argonaute Rna Limited Antagonist of pcsk9
CN119907691A (zh) * 2022-09-19 2025-04-29 厦门甘宝利生物医药有限公司 碳水化合物-寡核苷酸偶联物、药物组合物和治疗应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103614375A (zh) * 2006-05-11 2014-03-05 阿尔尼拉姆医药品有限公司 抑制pcsk9基因表达的组合物和方法
CA2892160C (en) * 2012-12-05 2021-03-23 Anna Borodovsky Pcsk9 irna compositions and methods of use thereof
MX2018002158A (es) * 2015-08-25 2018-07-06 Alnylam Pharmaceuticals Inc Mí‰TODOS Y COMPOSICIONES PARA TRATAR UN TRASTORNO ASOCIADO A GEN DE PROPROTEINA CONVERTASA SUBTILISINA KEXINA (PCSK9).
MX2019004573A (es) 2016-10-18 2019-10-07 The Medicines Co Metodos para evitar eventos cardiovasculares mediante la reduccion de la proproteinas convertasa subtilisina kexina 9 (pcsk9).

Also Published As

Publication number Publication date
PL3529360T3 (pl) 2024-08-26
WO2018075658A1 (en) 2018-04-26
IL266066A (en) 2019-06-30
AU2023263519A1 (en) 2023-12-07
LT3529360T (lt) 2024-07-25
EP3529360A1 (en) 2019-08-28
CN119318663A (zh) 2025-01-17
HRP20240930T1 (hr) 2024-10-11
RS65725B1 (sr) 2024-08-30
CL2019001047A1 (es) 2020-05-08
ES2982911T3 (es) 2024-10-18
KR20190077411A (ko) 2019-07-03
MX2024004495A (es) 2024-05-08
CN119345221A (zh) 2025-01-24
JP2022109948A (ja) 2022-07-28
JP2025016469A (ja) 2025-02-04
SI3529360T1 (sl) 2024-08-30
FI3529360T3 (fi) 2024-07-11
EP4397311A3 (en) 2024-10-16
CN110088283A (zh) 2019-08-02
HUE067712T2 (hu) 2024-11-28
AU2017346879A1 (en) 2019-05-23
US20180104360A1 (en) 2018-04-19
US20210093736A1 (en) 2021-04-01
EP3529360B1 (en) 2024-04-17
KR20250171391A (ko) 2025-12-08
CA3042423A1 (en) 2018-04-26
PT3529360T (pt) 2024-07-12
JP7181881B2 (ja) 2022-12-01
DK3529360T3 (da) 2024-07-15
JP2019531357A (ja) 2019-10-31
JP7566815B2 (ja) 2024-10-15
CN119700800A (zh) 2025-03-28
KR20240067272A (ko) 2024-05-16
EP4397311A2 (en) 2024-07-10
AU2017346879B2 (en) 2023-11-30
BR112019007843A2 (pt) 2019-10-01

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