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MX2019008117A - Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa. - Google Patents

Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa.

Info

Publication number
MX2019008117A
MX2019008117A MX2019008117A MX2019008117A MX2019008117A MX 2019008117 A MX2019008117 A MX 2019008117A MX 2019008117 A MX2019008117 A MX 2019008117A MX 2019008117 A MX2019008117 A MX 2019008117A MX 2019008117 A MX2019008117 A MX 2019008117A
Authority
MX
Mexico
Prior art keywords
protein kinase
inhibitors
metoxylated
cyclopenta
pyrimidines
Prior art date
Application number
MX2019008117A
Other languages
English (en)
Other versions
MX377920B (es
Inventor
Zhang Birong
F Blake James
M Wallace Eli
Xu Rui
Do Steven
Liang Jun
T Schlachter Stephen
s mitchell Ian
C Kallan Nicholas
Xiao Dengming
Safina Brian
Lee Spencer Keith
R Bencsik Josef
Chabot Christine
L Banka Anna
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38686743&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2019008117(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of MX2019008117A publication Critical patent/MX2019008117A/es
Publication of MX377920B publication Critical patent/MX377920B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)

Abstract

La presente invención proporciona compuestos, incluyendo sus enantiómeros resueltos, diestereómeros resueltos, solvatos y sales farmacéuticamente aceptables, que comprenden la Fórmula (I). También se proporcionan métodos de uso de los compuestos de esta invención como inhibidores de AKT proteína quinasa y para el tratamiento de enfermedades hiperproliferativas tales como cáncer.(VER FORMULA).
MX2019008117A 2006-07-06 2007-07-05 Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa MX377920B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81871806P 2006-07-06 2006-07-06
PCT/US2007/072885 WO2008006040A1 (en) 2006-07-06 2007-07-05 Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors

Publications (2)

Publication Number Publication Date
MX2019008117A true MX2019008117A (es) 2019-09-04
MX377920B MX377920B (es) 2025-03-11

Family

ID=38686743

Family Applications (4)

Application Number Title Priority Date Filing Date
MX2015013326A MX366319B (es) 2006-07-06 2007-07-05 Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa.
MX2019008117A MX377920B (es) 2006-07-06 2007-07-05 Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa
MX2008016202A MX2008016202A (es) 2006-07-06 2007-07-05 Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa.
MX2011010569A MX337843B (es) 2006-07-06 2008-12-17 Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015013326A MX366319B (es) 2006-07-06 2007-07-05 Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2008016202A MX2008016202A (es) 2006-07-06 2007-07-05 Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa.
MX2011010569A MX337843B (es) 2006-07-06 2008-12-17 Ciclopenta [d] pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa.

Country Status (34)

Country Link
EP (4) EP2399909B1 (es)
JP (4) JP5266216B2 (es)
KR (5) KR20140093291A (es)
CN (2) CN102816124A (es)
AR (3) AR061842A1 (es)
AT (1) ATE524447T1 (es)
AU (1) AU2007269060B2 (es)
BR (3) BR122013028005B8 (es)
CA (2) CA2836316A1 (es)
CL (1) CL2007001993A1 (es)
CO (1) CO6150161A2 (es)
CR (1) CR10600A (es)
CY (1) CY1112117T1 (es)
DK (2) DK2402325T3 (es)
ES (3) ES2554228T3 (es)
HR (1) HRP20110908T1 (es)
HU (1) HUE026237T2 (es)
IL (2) IL196028A (es)
IN (1) IN2014KN02886A (es)
MA (1) MA31655B1 (es)
MX (4) MX366319B (es)
MY (1) MY147364A (es)
NO (1) NO342346B1 (es)
NZ (3) NZ597647A (es)
PL (2) PL2402325T3 (es)
PT (1) PT2049501E (es)
RS (1) RS52212B (es)
RU (2) RU2478632C2 (es)
SG (4) SG188905A1 (es)
SI (2) SI2402325T1 (es)
TW (2) TW201332994A (es)
UA (1) UA95641C2 (es)
WO (1) WO2008006040A1 (es)
ZA (1) ZA200900070B (es)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5231411B2 (ja) * 2006-07-06 2013-07-10 アレイ バイオファーマ、インコーポレイテッド Ａｋｔプロテインキナーゼ阻害剤としてのジヒドロチエノピリミジン
MX2008016203A (es) 2006-07-06 2009-01-27 Array Biopharma Inc Ciclopenta [d] pirimidinas como inhibidores de la proteina cinasa akt.
UA95641C2 (xx) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
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