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MX2019006284A - Oligomeros antisentido y conjugados con diana en la proteina-convertasa subtilisina/kexina tipo 9(pcsk9). - Google Patents

Oligomeros antisentido y conjugados con diana en la proteina-convertasa subtilisina/kexina tipo 9(pcsk9).

Info

Publication number
MX2019006284A
MX2019006284A MX2019006284A MX2019006284A MX2019006284A MX 2019006284 A MX2019006284 A MX 2019006284A MX 2019006284 A MX2019006284 A MX 2019006284A MX 2019006284 A MX2019006284 A MX 2019006284A MX 2019006284 A MX2019006284 A MX 2019006284A
Authority
MX
Mexico
Prior art keywords
pcsk9
protein
sense
target
convertase subtilisin
Prior art date
Application number
MX2019006284A
Other languages
English (en)
Other versions
MX391977B (es
Inventor
Albaek Nanna
Ravn Jacob
Lindholm Marie
Hedtjärn Maj
Fisker Nielsen Niels
Petri Andreas
Original Assignee
Roche Innovation Ct Copenhagen As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2013/073858 external-priority patent/WO2014076195A1/en
Application filed by Roche Innovation Ct Copenhagen As filed Critical Roche Innovation Ct Copenhagen As
Publication of MX2019006284A publication Critical patent/MX2019006284A/es
Publication of MX391977B publication Critical patent/MX391977B/es

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Abstract

La presente invención se refiere a compuestos oligoméricos y conjugados de los mismos con diana en el ARNm de la proproteína-convertasa subtilisina/kexina tipo 9 (PCSK9) en una célula, que conducen a una expresión reducida de PCSK9. La reducción de la expresión de PCSK9 resulta beneficiosa para una gama de trastornos médicos, tales como la hipercolesterolemia y trastornos relacionados.
MX2019006284A 2013-06-27 2014-06-27 Oligómeros antisentido y conjugados con diana en la proteína-convertasa subtilisina/kexina tipo 9(pcsk9). MX391977B (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP13174092 2013-06-27
EP13192930 2013-11-14
EP13192938 2013-11-14
PCT/EP2013/073858 WO2014076195A1 (en) 2012-11-15 2013-11-14 Oligonucleotide conjugates
EP14153253 2014-01-30
EP14168331 2014-05-14
PCT/EP2014/063757 WO2014207232A1 (en) 2013-06-27 2014-06-27 Antisense oligomers and conjugates targeting pcsk9

Publications (2)

Publication Number Publication Date
MX2019006284A true MX2019006284A (es) 2019-08-29
MX391977B MX391977B (es) 2025-03-21

Family

ID=52141126

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015017601A MX367083B (es) 2013-06-27 2014-06-27 Oligomeros antisentido y conjugados con diana en la proteina-convertasa subtilisina/kexina tipo 9(pcsk9).
MX2019006284A MX391977B (es) 2013-06-27 2014-06-27 Oligómeros antisentido y conjugados con diana en la proteína-convertasa subtilisina/kexina tipo 9(pcsk9).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015017601A MX367083B (es) 2013-06-27 2014-06-27 Oligomeros antisentido y conjugados con diana en la proteina-convertasa subtilisina/kexina tipo 9(pcsk9).

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Country Link
US (7) US9879265B2 (es)
EP (2) EP3013959B1 (es)
JP (2) JP6255092B2 (es)
KR (2) KR101931089B1 (es)
CN (2) CN112263682B (es)
AU (1) AU2014300981B2 (es)
BR (1) BR112015032432B1 (es)
CA (1) CA2915316C (es)
CL (1) CL2015003728A1 (es)
CY (1) CY1122738T1 (es)
DK (1) DK3013959T3 (es)
EA (1) EA201592215A1 (es)
ES (1) ES2770667T3 (es)
HR (1) HRP20200163T1 (es)
HU (1) HUE048738T2 (es)
IL (1) IL242875B (es)
LT (1) LT3013959T (es)
MX (2) MX367083B (es)
MY (1) MY183049A (es)
NZ (1) NZ715081A (es)
PE (1) PE20160158A1 (es)
PH (1) PH12015502761A1 (es)
PL (1) PL3013959T3 (es)
PT (1) PT3013959T (es)
RS (1) RS59986B1 (es)
SG (2) SG10201908122XA (es)
SI (1) SI3013959T1 (es)
SM (1) SMT202000104T1 (es)
UA (1) UA119643C2 (es)
WO (1) WO2014207232A1 (es)

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