MX2019006165A - Proceso para la preparacion de derivados del acido biliar de las sulfonilureas. - Google Patents
Proceso para la preparacion de derivados del acido biliar de las sulfonilureas.Info
- Publication number
- MX2019006165A MX2019006165A MX2019006165A MX2019006165A MX2019006165A MX 2019006165 A MX2019006165 A MX 2019006165A MX 2019006165 A MX2019006165 A MX 2019006165A MX 2019006165 A MX2019006165 A MX 2019006165A MX 2019006165 A MX2019006165 A MX 2019006165A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- present
- acid derivatives
- compound
- sulfonylureas
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 238000002360 preparation method Methods 0.000 title abstract 5
- 229940100389 Sulfonylurea Drugs 0.000 title 1
- 239000003613 bile acid Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- IGRCWJPBLWGNPX-UHFFFAOYSA-N 3-(2-chlorophenyl)-n-(4-chlorophenyl)-n,5-dimethyl-1,2-oxazole-4-carboxamide Chemical compound C=1C=C(Cl)C=CC=1N(C)C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl IGRCWJPBLWGNPX-UHFFFAOYSA-N 0.000 abstract 2
- 102100025353 G-protein coupled bile acid receptor 1 Human genes 0.000 abstract 2
- 101000857733 Homo sapiens G-protein coupled bile acid receptor 1 Proteins 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical class C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 abstract 1
- 125000001664 diethylamino group Chemical class [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se relaciona con a proceso para la preparación de un compuesto de la Fórmula(I): (ver fórmula) o un solvato o sal aceptable farmacéuticamente del mismo. Estos compuestos y composiciones farmacéuticas son útiles como moduladores de FXR o TGR5. Específicamente, la presente invención se refiere a derivados de ácido biliar y métodos para su preparación y uso. La presente invención se refiere a un proceso para la preparación de un compuesto (II) y sus sales y derivados que son intermediarios útiles en la síntesis de moléculas biológicamente activas, especialmente en la síntesis de moduladores de FXR y TGR5 (ver fórmula). La presente invención también se refiere a un proceso para la preparación de un compuesto (III) y su sal de dietilamina (ver fórmula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662427354P | 2016-11-29 | 2016-11-29 | |
| PCT/US2017/063720 WO2018102418A1 (en) | 2016-11-29 | 2017-11-29 | Process for preparation of sulfonylurea bile acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019006165A true MX2019006165A (es) | 2019-10-14 |
| MX378555B MX378555B (es) | 2025-03-10 |
Family
ID=62188840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019006165A MX378555B (es) | 2016-11-29 | 2017-11-29 | Proceso para la preparacion de derivados del acido biliar de las sulfonilureas |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10584145B2 (es) |
| EP (1) | EP3548038B1 (es) |
| JP (1) | JP7057783B2 (es) |
| KR (1) | KR102499441B1 (es) |
| CN (1) | CN110121347A (es) |
| AU (1) | AU2017368069B2 (es) |
| BR (1) | BR112019010798A2 (es) |
| CA (1) | CA3045023A1 (es) |
| ES (1) | ES2918698T3 (es) |
| MX (1) | MX378555B (es) |
| WO (1) | WO2018102418A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170094184A (ko) | 2014-11-06 | 2017-08-17 | 이난타 파마슈티칼스, 인코포레이티드 | Fxr/tgr5 작용제로서의 담즙산 유사체 및 이의 이용 방법 |
| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| KR20170099909A (ko) | 2014-11-26 | 2017-09-01 | 이난타 파마슈티칼스, 인코포레이티드 | Fxr/tgr5 작용제로서의 담즙산 유사체 및 이의 이용 방법 |
| WO2016086115A1 (en) | 2014-11-26 | 2016-06-02 | Enanta Pharmaceuticals, Inc. | Tetrazole derivatives of bile acids as fxr/tgr5 agonists and methods of use thereof |
| ES2886766T3 (es) | 2015-03-31 | 2021-12-20 | Enanta Pharm Inc | Derivados del ácido biliar como agonistas de FXR/TGR5 y métodos de uso de estos |
| WO2017147174A1 (en) | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Heteroaryl containing bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
| WO2017147137A1 (en) | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Benzoic acid derivatives of bile acid as fxr/tgr5 agonists and methods of use thereof |
| CN110121347A (zh) * | 2016-11-29 | 2019-08-13 | 英安塔制药有限公司 | 制备磺酰脲胆汁酸衍生物的方法 |
| WO2018152171A1 (en) | 2017-02-14 | 2018-08-23 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as fxr agonists and methods of use thereof |
| EP3606533B1 (en) | 2017-04-07 | 2023-11-15 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonyl carbamate bile acid derivatives |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1592791A (en) | 1977-01-07 | 1981-07-08 | Radiochemical Centre Ltd | Selenium- or tellurium-containing bile acids and derivatives thereof |
| EP0243449A1 (en) | 1985-10-18 | 1987-11-04 | The Upjohn Company | Cyclic hydrocarbons with an aminoalkyl sidechain |
| IT1255449B (it) | 1992-06-30 | 1995-10-31 | Fabio Berlati | Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci. |
| IT1255485B (it) | 1992-08-04 | 1995-11-06 | Erregierre Ind Chim | Processo per preparare gli acidi biliari coniugati con la glicina e relative composizioni terapeutiche per il trattamento dell'insufficienza epatica |
| TW289020B (es) | 1993-05-08 | 1996-10-21 | Hoechst Sktiengesellschaft | |
| TW289757B (es) | 1993-05-08 | 1996-11-01 | Hoechst Ag | |
| US5541348A (en) | 1994-03-10 | 1996-07-30 | National Research Council Of Canada | Bile acids for biological and chemical applications and processes for the production thereof |
| US5646316A (en) | 1994-04-08 | 1997-07-08 | Osteoarthritis Sciences, Inc. | Bile acid inhibitors of metalloproteinase enzymes |
| JPH1160594A (ja) | 1997-08-25 | 1999-03-02 | Sankyo Co Ltd | 胆汁酸誘導体 |
| JP3865890B2 (ja) | 1997-09-30 | 2007-01-10 | 富士フイルムホールディングス株式会社 | ポジ型感光性組成物 |
| US6639078B1 (en) | 1998-12-23 | 2003-10-28 | Smithkline Beecham Corporation | Assays for ligands for nuclear receptors |
| US20020132223A1 (en) | 1999-03-26 | 2002-09-19 | City Of Hope | Methods for modulating activity of the FXR nuclear receptor |
| US20020098999A1 (en) | 2000-10-06 | 2002-07-25 | Gallop Mark A. | Compounds for sustained release of orally delivered drugs |
| WO2002028881A1 (en) | 2000-10-06 | 2002-04-11 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
| US7138390B2 (en) | 2001-03-12 | 2006-11-21 | Intercept Pharmaceuticals | Steroids as agonists for FXR |
| AU2003228485A1 (en) | 2002-04-12 | 2003-10-27 | The University Of Chicago | Farnesoid x-activated receptor agonists |
| ITMI20021080A1 (it) | 2002-05-21 | 2003-11-21 | Marcello Izzo | Associazioni farmaceutiche per uso topico a base di chelati del ferroinibitori delle metalloproteasi e fattore xiii per il trattamento dell |
| EP1568706A1 (en) | 2004-02-26 | 2005-08-31 | Intercept Pharmaceuticals, Inc. | Novel steroid agonist for FXR |
| SI1734970T1 (sl) | 2004-03-12 | 2015-04-30 | Intercept Pharmaceuticals, Inc. | Zdravljenje fibroze z uporabo FXR ligandov |
| ITMI20050912A1 (it) | 2005-05-19 | 2006-11-20 | Erregierre Spa | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
| US20070190067A1 (en) | 2006-02-01 | 2007-08-16 | Savage Paul B | Cationic Steroid Antimicrobial Compositions and Methods of Use |
| CN101395170A (zh) | 2006-02-14 | 2009-03-25 | 英特塞普特药品公司 | 用于预防或治疗fxr介导的疾病或状态的作为fxr配体的胆汁酸衍生物 |
| WO2007111994A2 (en) | 2006-03-22 | 2007-10-04 | Syndexa Pharmaceuticals Corporation | Compounds and methods for treatment of disorders associated with er stress |
| WO2008002573A2 (en) | 2006-06-27 | 2008-01-03 | Intercept Pharmaceuticals, Inc. | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated deseases or conditions |
| US20090258847A1 (en) | 2006-07-17 | 2009-10-15 | Erwin Paul Schreiner | Cholanic Acid Amides |
| EP2112995B1 (en) | 2007-01-19 | 2013-07-31 | Intercept Pharmaceuticals, Inc. | 23-substituted bile acids as tgr5 modulators and methods of use thereof |
| EP1947108A1 (en) | 2007-01-19 | 2008-07-23 | Intercept Pharmaceuticals, Inc. | TGR5 modulators and methods of use thereof |
| US8338628B2 (en) | 2007-08-28 | 2012-12-25 | City Of Hope | Method of synthesizing alkylated bile acid derivatives |
| WO2009032321A2 (en) | 2007-09-06 | 2009-03-12 | Genaera Corporation | A method for treating diabetes |
| US20090163474A1 (en) | 2007-10-19 | 2009-06-25 | Wyeth | FXR Agonists for the Treatment of Nonalcoholic Fatty Liver and Cholesterol Gallstone Diseases |
| KR101239008B1 (ko) | 2008-03-31 | 2013-03-04 | 한양대학교 산학협력단 | 바일산 유도체 및 그의 응용 |
| CN105037476B (zh) | 2008-07-30 | 2018-06-12 | 英特塞普特医药品公司 | Tgr5调节剂及其使用方法 |
| EP3540059A1 (en) * | 2010-04-16 | 2019-09-18 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
| WO2012024581A2 (en) * | 2010-08-20 | 2012-02-23 | Fate Therapeutics, Inc. | Oxysterol compounds |
| WO2013020108A2 (en) | 2011-08-04 | 2013-02-07 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of pancreatitis |
| WO2013049595A1 (en) | 2011-09-29 | 2013-04-04 | Ethicon Endo-Surgery, Inc. | Methods and compositions of bile acids |
| WO2013166176A1 (en) | 2012-05-01 | 2013-11-07 | Catabasis Pharmaceuticals, Inc. | Fatty acid conjugates of statin and fxr agonists; compositions and method of uses |
| SG11201408501UA (en) * | 2012-06-19 | 2015-01-29 | Intercept Pharmaceuticals Inc | Preparation, uses and solid forms of obeticholic acid |
| US9079935B2 (en) | 2012-08-13 | 2015-07-14 | The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas | Reducing risk of contracting Clostridium-difficile associated disease |
| WO2014036377A1 (en) | 2012-08-31 | 2014-03-06 | Metselex | Methods of promoting cell viability |
| US9814733B2 (en) | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
| US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
| US20140206657A1 (en) | 2013-01-18 | 2014-07-24 | City Of Hope | Bile acid analog tgr5 agonists |
| PT2997035T (pt) | 2013-05-14 | 2018-07-18 | Intercept Pharmaceuticals Inc | Derivados de 11-hidroxilo substituídos em 6 de ácidos biliares e seus conjugados de aminoácido como moduladores do recetor farnesoide x |
| AU2014296023B2 (en) | 2013-08-01 | 2020-02-06 | The Penn State Research Foundation | Inhibitors of the farnesoid X receptor and uses in medicine |
| US20150112089A1 (en) | 2013-10-22 | 2015-04-23 | Metselex, Inc. | Deuterated bile acids |
| CN106661079B (zh) | 2014-05-29 | 2019-03-01 | 巴尔制药有限公司 | 用于治疗和/或预防fxr和tgr5/gpbar1介导的疾病的胆烷衍生物 |
| KR20170094184A (ko) | 2014-11-06 | 2017-08-17 | 이난타 파마슈티칼스, 인코포레이티드 | Fxr/tgr5 작용제로서의 담즙산 유사체 및 이의 이용 방법 |
| CN111944006B (zh) | 2014-11-17 | 2021-12-17 | 正大天晴药业集团股份有限公司 | 新的7-酮-6β-烷基胆烷酸衍生物在制备奥贝胆酸以及其在医药领域的用途 |
| CN107207559B (zh) * | 2014-11-19 | 2019-10-25 | Nzp英国有限公司 | 作为制备类固醇fxr调节剂的中间体的6-烷基-7-羟基-4-烯-3-酮类固醇 |
| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| KR20170099909A (ko) | 2014-11-26 | 2017-09-01 | 이난타 파마슈티칼스, 인코포레이티드 | Fxr/tgr5 작용제로서의 담즙산 유사체 및 이의 이용 방법 |
| WO2016086134A1 (en) | 2014-11-26 | 2016-06-02 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
| WO2016086115A1 (en) | 2014-11-26 | 2016-06-02 | Enanta Pharmaceuticals, Inc. | Tetrazole derivatives of bile acids as fxr/tgr5 agonists and methods of use thereof |
| US20160176917A1 (en) * | 2014-11-26 | 2016-06-23 | Enanta Pharmaceuticals, Inc. | Bile Acid Derivatives as FXR/TGR5 Agonists and Methods of Use Thereof |
| WO2016130809A1 (en) | 2015-02-11 | 2016-08-18 | Enanta Pharmaceuticals, Inc. | Bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
| CN104804055B (zh) * | 2015-03-18 | 2016-07-06 | 苏州天绿生物制药有限公司 | 一种采用硅烷化试剂纯化7-酮石胆酸的方法 |
| ES2886766T3 (es) | 2015-03-31 | 2021-12-20 | Enanta Pharm Inc | Derivados del ácido biliar como agonistas de FXR/TGR5 y métodos de uso de estos |
| CN106083978A (zh) * | 2015-04-28 | 2016-11-09 | 上海迪诺医药科技有限公司 | 磺酰基氨基羰基衍生物、其药物组合物及应用 |
| CN111116699B (zh) | 2015-04-28 | 2023-02-28 | 江苏豪森药业集团有限公司 | 胆酸衍生物及其制备方法和医药用途 |
| CN107531743B (zh) | 2015-04-29 | 2020-05-05 | 正大天晴药业集团股份有限公司 | 鹅去氧胆酸衍生物 |
| CN107771180B (zh) | 2015-06-19 | 2021-03-23 | 英特塞普特医药品公司 | Tgr5调节剂及其使用方法 |
| AU2016306297A1 (en) | 2015-08-07 | 2018-02-22 | Intercept Pharmaceuticals, Inc. | Methods for preparation of bile acids and derivatives thereof |
| CN105175473B (zh) | 2015-08-19 | 2018-12-21 | 丽珠医药集团股份有限公司 | 一种奥贝胆酸晶型i及其制备方法、药物组合物和用途 |
| CN106478759A (zh) | 2015-08-31 | 2017-03-08 | 陕西合成药业股份有限公司 | 奥贝胆酸衍生物及其制备方法和用途 |
| CN106518946A (zh) * | 2015-09-10 | 2017-03-22 | 上海迪诺医药科技有限公司 | 磺酰脲衍生物、其药物组合物及应用 |
| KR20180052756A (ko) | 2015-09-24 | 2018-05-18 | 인터셉트 파마슈티컬즈, 인크. | 담즙산 유도체 제조를 위한 방법 및 중간체 |
| MA45761A (fr) | 2015-10-07 | 2021-04-21 | Intercept Pharmaceuticals Inc | Modulateurs du récepteur farnésoïde x |
| MY196292A (en) | 2016-01-28 | 2023-03-24 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Steroid Derivative Fxr Agonist |
| WO2017147174A1 (en) | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Heteroaryl containing bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
| WO2017147159A1 (en) | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Deuterated bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
| WO2017147137A1 (en) | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Benzoic acid derivatives of bile acid as fxr/tgr5 agonists and methods of use thereof |
| CA3016875C (en) | 2016-03-11 | 2023-08-22 | Intercept Pharmaceuticals, Inc. | 3-desoxy derivative and pharmaceutical compositions thereof |
| CN110121347A (zh) | 2016-11-29 | 2019-08-13 | 英安塔制药有限公司 | 制备磺酰脲胆汁酸衍生物的方法 |
| WO2018152171A1 (en) | 2017-02-14 | 2018-08-23 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as fxr agonists and methods of use thereof |
| EP3606533B1 (en) | 2017-04-07 | 2023-11-15 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonyl carbamate bile acid derivatives |
-
2017
- 2017-11-29 CN CN201780081494.2A patent/CN110121347A/zh active Pending
- 2017-11-29 US US15/826,233 patent/US10584145B2/en active Active
- 2017-11-29 JP JP2019528041A patent/JP7057783B2/ja not_active Expired - Fee Related
- 2017-11-29 ES ES17877352T patent/ES2918698T3/es active Active
- 2017-11-29 KR KR1020197018568A patent/KR102499441B1/ko active Active
- 2017-11-29 BR BR112019010798A patent/BR112019010798A2/pt active Search and Examination
- 2017-11-29 EP EP17877352.9A patent/EP3548038B1/en active Active
- 2017-11-29 MX MX2019006165A patent/MX378555B/es unknown
- 2017-11-29 AU AU2017368069A patent/AU2017368069B2/en not_active Ceased
- 2017-11-29 WO PCT/US2017/063720 patent/WO2018102418A1/en not_active Ceased
- 2017-11-29 CA CA3045023A patent/CA3045023A1/en active Pending
-
2020
- 2020-02-07 US US16/784,296 patent/US10947264B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20200247839A1 (en) | 2020-08-06 |
| KR20190114960A (ko) | 2019-10-10 |
| US10947264B2 (en) | 2021-03-16 |
| EP3548038B1 (en) | 2022-04-13 |
| KR102499441B1 (ko) | 2023-02-13 |
| WO2018102418A1 (en) | 2018-06-07 |
| JP2019535777A (ja) | 2019-12-12 |
| AU2017368069B2 (en) | 2021-07-08 |
| EP3548038A1 (en) | 2019-10-09 |
| CN110121347A (zh) | 2019-08-13 |
| US20180148469A1 (en) | 2018-05-31 |
| MX378555B (es) | 2025-03-10 |
| AU2017368069A1 (en) | 2019-06-13 |
| CA3045023A1 (en) | 2018-06-07 |
| US10584145B2 (en) | 2020-03-10 |
| BR112019010798A2 (pt) | 2019-10-01 |
| EP3548038A4 (en) | 2020-07-01 |
| JP7057783B2 (ja) | 2022-04-20 |
| ES2918698T3 (es) | 2022-07-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2019006165A (es) | Proceso para la preparacion de derivados del acido biliar de las sulfonilureas. | |
| CO2018011408A2 (es) | Compuestos de pirimidina como inhibidores de la quinasa jak | |
| CO2018012171A2 (es) | Piridinas sustituidas con heteroarilo y métodos de uso | |
| NI201400107A (es) | Compuestos de heterociclilo como inhibidores de mek | |
| CR20160212A (es) | Composiciones y métodos para modular los receptores x farnesoides | |
| CR10614A (es) | Derivados heterociclicos fusionados y metodos de uso | |
| MX2018015892A (es) | Derivados de acido boronico y usos terapeuticos de los mismos. | |
| MX2017012558A (es) | Derivados de ácido biliar como agonistas de fxr/tgr5 y métodos para su uso. | |
| UY34917A (es) | Inhibidores de la producción de leucotrieno-a4-hidrolasa (lta4h), composiciones farmacéuticas que los contienen y proceso para su preparación | |
| DOP2020000083A (es) | Compuesto de pirimidina como inhibidor de las janocinasas | |
| UY33501A (es) | Derivados de acil sulfonamida y sus sales farmacéuticamente aceptables para uso en medicina | |
| IN2015DN01442A (es) | ||
| EA201590539A1 (ru) | C17-гетероарильные производные олеаноловой кислоты и способы их применения | |
| EA201500298A1 (ru) | Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы | |
| MX388300B (es) | Proceso para la preparación de derivados de ácidos biliares de sulfonil carbamato | |
| EA201592144A1 (ru) | Производное фенола, способ его получения и его применение в медицине | |
| MX2015008233A (es) | Nuevos derivados de quinolona. | |
| MX2020004283A (es) | Derivados de piridincarbonilo y usos terapéuticos de los mismos como inhibidores de trpc6. | |
| MX375863B (es) | Esteroides de 6-alquil-7-hidroxi-4-en-3-ona como intermedios para la produccion de moduladores esteroideos del receptor x farnesoide (fxr) | |
| MX2018014164A (es) | Intermedios para la sintesis de derivados de acido biliar, en particular, de acido obeticolico. | |
| MX375864B (es) | Esteroides de 5.beta-6-alquil-7-hidroxi-3-ona como intermedios para la produccion de moduladores esteroideos del receptor x farnesoide (fxr) | |
| MX381239B (es) | Esteroides de 6.alfa.-alquil-6,7-diona como intermedios para la producción de moduladores esteroideos del receptor x farnesoide (fxr). | |
| MX2020003495A (es) | Derivados de acido boronico y sintesis de los mismos. | |
| UY33200A (es) | Derivados de ácido 3-heteroaroilamino-propiónico sustituidos con oxígeno y su uso como productos farmacéuticos | |
| CO7160077A2 (es) | Compuestos de pirazol sustituidos como antagonistas de lpar |