MX2019004651A - Metodos para el tratamiento de la atrofia muscular y enfermedad osea con el uso de proteinas trap hibridas novedosas del ligando actriib. - Google Patents
Metodos para el tratamiento de la atrofia muscular y enfermedad osea con el uso de proteinas trap hibridas novedosas del ligando actriib.Info
- Publication number
- MX2019004651A MX2019004651A MX2019004651A MX2019004651A MX2019004651A MX 2019004651 A MX2019004651 A MX 2019004651A MX 2019004651 A MX2019004651 A MX 2019004651A MX 2019004651 A MX2019004651 A MX 2019004651A MX 2019004651 A MX2019004651 A MX 2019004651A
- Authority
- MX
- Mexico
- Prior art keywords
- present disclosure
- ligand trap
- methods
- actriib ligand
- subject
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 title abstract 3
- 239000003446 ligand Substances 0.000 title abstract 3
- 208000020084 Bone disease Diseases 0.000 title abstract 2
- 206010028289 Muscle atrophy Diseases 0.000 title abstract 2
- 201000000585 muscular atrophy Diseases 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 201000011529 cardiovascular cancer Diseases 0.000 abstract 2
- 208000020832 chronic kidney disease Diseases 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 208000007502 anemia Diseases 0.000 abstract 1
- 208000022531 anorexia Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 206010061428 decreased appetite Diseases 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000033667 organ regeneration Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 230000017423 tissue regeneration Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente descripción describe polipéptidos híbridos ActRIIB-ECD solubles novedosos. La presente descripción proporciona métodos para el tratamiento o la prevención de la atrofia muscular, enfermedad ósea, una enfermedad metabólica, fibrosis, una enfermedad auto inmune/inflamatoria una enfermedad cardiovascular, cáncer O cáncer, enfermedad renal crónica (CKD)I al iritisI anorexia, enfermedad hepática, rechazo de trasplante de órganos O tejidos anemia, dolor y/o envejecimiento en un sujeto que lo necesite. Además, la presente descripción proporciona métodos para inducir el crecimiento de células madre para la reparación de tejidos o la regeneración de órganos en un sujeto Los métodos ante mencionados comprenden la administración al sujeto de una cantidad terapéuticamente eficaz de un polipéptido trap híbrido del ligando ActRIIB. La presente descripción proporciona también composiciones farmacéuticas que comprenden polipéptidos trap híbridos del ligando ActRIIB.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662410595P | 2016-10-20 | 2016-10-20 | |
| PCT/US2017/057351 WO2018075747A1 (en) | 2016-10-20 | 2017-10-19 | Methods for treating muscle wasting and bone disease using novel hybrid actriib ligand trap proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019004651A true MX2019004651A (es) | 2019-10-09 |
Family
ID=62019496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019004651A MX2019004651A (es) | 2016-10-20 | 2017-10-19 | Metodos para el tratamiento de la atrofia muscular y enfermedad osea con el uso de proteinas trap hibridas novedosas del ligando actriib. |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US20190330307A1 (es) |
| EP (1) | EP3528833B1 (es) |
| JP (1) | JP2019535675A (es) |
| KR (1) | KR20190071758A (es) |
| CN (1) | CN109922821A (es) |
| AU (1) | AU2017345435B2 (es) |
| CA (1) | CA3039066A1 (es) |
| CL (1) | CL2019001069A1 (es) |
| CO (1) | CO2019005115A2 (es) |
| CR (1) | CR20190247A (es) |
| EA (1) | EA201990971A1 (es) |
| IL (1) | IL266032B2 (es) |
| JO (1) | JOP20190085A1 (es) |
| MA (1) | MA46585A (es) |
| MX (1) | MX2019004651A (es) |
| PE (1) | PE20190743A1 (es) |
| PH (1) | PH12019500853A1 (es) |
| SG (2) | SG10201913301TA (es) |
| TN (1) | TN2019000119A1 (es) |
| TW (1) | TWI826358B (es) |
| WO (1) | WO2018075747A1 (es) |
| ZA (1) | ZA201903105B (es) |
Families Citing this family (17)
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|---|---|---|---|---|
| MA41919A (fr) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
| MX391964B (es) | 2015-04-06 | 2025-03-21 | Acceleron Pharma Inc | Heteromultimeros de receptor de superfamilia de tgf-beta tipo i y tipo ii y usos de los mismos. |
| US10358476B2 (en) | 2015-04-06 | 2019-07-23 | Acceleron Pharma Inc. | Single arm type I and type II receptor fusion proteins and uses thereof |
| US11267865B2 (en) | 2016-10-05 | 2022-03-08 | Acceleron Pharma Inc. | Variant ActRIIB proteins and uses thereof |
| US10934532B2 (en) | 2016-10-05 | 2021-03-02 | Acceleron Pharma Inc. | ALK4.ActRIIB heteromultimers |
| JOP20190085A1 (ar) | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| JP7139326B2 (ja) | 2016-11-10 | 2022-09-20 | ケロス セラピューティクス インコーポレイテッド | アクチビンＩＩａ型受容体変異体および同変異体を含む医薬組成物 |
| KR20200085832A (ko) | 2017-11-09 | 2020-07-15 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법 |
| JP7510875B2 (ja) | 2018-01-12 | 2024-07-04 | ケロス セラピューティクス インコーポレイテッド | アクチビンｉｉｂ型受容体変異体および同変異体を含む医薬組成物 |
| KR20250133994A (ko) | 2018-05-09 | 2025-09-09 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법 |
| AU2021217966A1 (en) * | 2020-02-03 | 2022-09-29 | Acceleron Pharma Inc. | Variant ActRIIBb proteins and uses thereof |
| EP4121090A4 (en) * | 2020-03-20 | 2024-09-04 | Keros Therapeutics, Inc. | Methods of using activin receptor type iia variants |
| WO2021189010A1 (en) * | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
| KR20230004515A (ko) | 2020-03-20 | 2023-01-06 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 ii 키메라 및 이의 사용 방법 |
| AU2021256419A1 (en) * | 2020-04-13 | 2022-10-20 | Celgene Corporation | Methods for treating anemia using an actRIIB ligand trap and fedratinib |
| EP4274600A4 (en) * | 2021-01-08 | 2024-11-20 | Acceleron Pharma Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PULMONARY HYPERTENSION |
| EP4653010A1 (en) * | 2024-05-14 | 2025-11-26 | 35Pharma Inc. | Activin receptor type iib traps for use in improving body composition |
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2017
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| CN109922821A (zh) | 2019-06-21 |
| PH12019500853A1 (en) | 2019-12-02 |
| CO2019005115A2 (es) | 2019-05-31 |
| US20250109183A1 (en) | 2025-04-03 |
| IL266032A (en) | 2019-06-30 |
| CA3039066A1 (en) | 2018-04-26 |
| EA201990971A1 (ru) | 2019-10-31 |
| TW201827069A (zh) | 2018-08-01 |
| ZA201903105B (en) | 2023-03-29 |
| EP3528833A1 (en) | 2019-08-28 |
| CL2019001069A1 (es) | 2019-08-23 |
| TWI826358B (zh) | 2023-12-21 |
| US20190330307A1 (en) | 2019-10-31 |
| SG10201913301TA (en) | 2020-03-30 |
| SG11201903450YA (en) | 2019-05-30 |
| PE20190743A1 (es) | 2019-05-27 |
| MA46585A (fr) | 2019-08-28 |
| US12187783B2 (en) | 2025-01-07 |
| EP3528833B1 (en) | 2025-12-24 |
| JP2019535675A (ja) | 2019-12-12 |
| US20220332791A1 (en) | 2022-10-20 |
| WO2018075747A1 (en) | 2018-04-26 |
| TN2019000119A1 (en) | 2020-10-05 |
| AU2017345435A1 (en) | 2019-05-23 |
| EP3528833A4 (en) | 2020-11-25 |
| CR20190247A (es) | 2019-07-29 |
| IL266032B2 (en) | 2024-06-01 |
| JOP20190085A1 (ar) | 2019-04-17 |
| AU2017345435B2 (en) | 2021-11-11 |
| KR20190071758A (ko) | 2019-06-24 |
| IL266032B1 (en) | 2024-02-01 |
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