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MX2019004593A - Vectores recombinantes que expresan antigenos de virus de influenza aviar y usos de los mismos. - Google Patents

Vectores recombinantes que expresan antigenos de virus de influenza aviar y usos de los mismos.

Info

Publication number
MX2019004593A
MX2019004593A MX2019004593A MX2019004593A MX2019004593A MX 2019004593 A MX2019004593 A MX 2019004593A MX 2019004593 A MX2019004593 A MX 2019004593A MX 2019004593 A MX2019004593 A MX 2019004593A MX 2019004593 A MX2019004593 A MX 2019004593A
Authority
MX
Mexico
Prior art keywords
same
recombinant vectors
avian influenza
influenza viruses
express antigens
Prior art date
Application number
MX2019004593A
Other languages
English (en)
Other versions
MX385918B (es
Inventor
Mebatsion Teshome
Pritchard Joyce
SWAYNE David
Original Assignee
Boehringer Ingelheim Animal Health Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Animal Health Usa Inc filed Critical Boehringer Ingelheim Animal Health Usa Inc
Publication of MX2019004593A publication Critical patent/MX2019004593A/es
Publication of MX385918B publication Critical patent/MX385918B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
    • C12N2710/16341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención proporciona vectores virales recombinantes que contienen y expresan antígenos de patógenos aviares, composiciones que comprenden los vectores virales recombinantes, vacunas polivalentes que comprenden los vectores virales recombinantes. La presente invención además proporciona métodos de vacunación contra una variedad de patógenos aviares y método para producir los vectores virales recombinantes.
MX2019004593A 2016-10-21 2017-10-20 Vectores recombinantes que expresan antígenos de virus de influenza aviar y usos de los mismos. MX385918B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662410885P 2016-10-21 2016-10-21
PCT/US2017/057741 WO2018075977A1 (en) 2016-10-21 2017-10-20 Recombinant vectors expressing antigens of avian influenza virus and uses thereof

Publications (2)

Publication Number Publication Date
MX2019004593A true MX2019004593A (es) 2019-08-14
MX385918B MX385918B (es) 2025-03-18

Family

ID=60452725

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019004593A MX385918B (es) 2016-10-21 2017-10-20 Vectores recombinantes que expresan antígenos de virus de influenza aviar y usos de los mismos.

Country Status (17)

Country Link
US (1) US11058761B2 (es)
EP (2) EP3528842A1 (es)
KR (1) KR20190073460A (es)
CN (1) CN110072548A (es)
CA (1) CA3041304A1 (es)
IL (1) IL266148B2 (es)
JO (1) JOP20190088A1 (es)
MA (1) MA46580A (es)
MX (1) MX385918B (es)
MY (1) MY191322A (es)
PH (1) PH12019500854A1 (es)
RU (1) RU2761869C2 (es)
SA (1) SA519401606B1 (es)
TN (1) TN2019000127A1 (es)
TW (1) TW201829454A (es)
WO (1) WO2018075977A1 (es)
ZA (1) ZA201902525B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109310750B (zh) 2016-06-17 2022-08-12 英特维特国际股份有限公司 编码传染性喉气管炎病毒和传染性法氏囊病病毒抗原的重组非致病性马立克氏病病毒构建体
JOP20190088A1 (ar) * 2016-10-21 2019-04-21 Us Agriculture نواقل مؤتلفة للتعبير عن مولدات مضاد فيروس انفلونزا الطيور و استخداماتها
BR112020007213A2 (pt) 2017-10-12 2020-10-13 Intervet International B.V. construtos de vírus da doença de marek não patogênico recombinante que codificam múltiplos antígenos heterólogos
CN113226363B (zh) * 2018-12-21 2024-08-23 法国诗华大药厂 含有多个外来基因的重组禽疱疹病毒
UA130085C2 (uk) * 2019-09-11 2025-11-05 Зоетіс Сервісіс Ллк Рекомбінантний геном вірусу герпесу індички, що експресує антигени патогенів птахів, та його застосування
CN113827713B (zh) * 2020-06-23 2024-07-05 普莱柯生物工程股份有限公司 一种抗h7亚型禽流感病毒的疫苗组合物、及其制备方法和应用
CN113603754B (zh) * 2021-08-23 2024-05-24 福建省农业科学院畜牧兽医研究所 一种水禽h5n8亚型流感病毒ha重组蛋白及其制备方法与应用
CN113913394B (zh) * 2021-10-19 2022-06-21 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 人工重组的h5n6流感病毒及其制备方法和应用
CN114524862B (zh) * 2021-12-16 2022-12-27 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 禽流感(h5+h7)三价dna疫苗的构建及其应用
KR102846432B1 (ko) 2022-11-15 2025-08-18 대한민국 재조합 h5n1 조류 인플루엔자 바이러스 및 이를 이용한 고병원성 조류 인플루엔자 백신 및 제조방법
KR20240087508A (ko) 2022-11-25 2024-06-19 대한민국(농림축산식품부 농림축산검역본부장) Clade 2.3.2.1d/2.3.4.4b에 속하는 고병원성 조류 인플루엔자 A 바이러스 예방용 재조합 다가 백신 조성물 및 이의 제조 방법
CN120555370A (zh) * 2024-02-29 2025-08-29 诗华动保科技(杭州)有限公司 重组hvt及其应用
KR20250137778A (ko) 2024-03-11 2025-09-19 대한민국(농림축산식품부 농림축산검역본부장) Clade 2.3.2.1d에 속하는 재조합 조류 인플루엔자 A 바이러스 합성주, 및 이를 이용한 고병원성 조류 인플루엔자 백신 및 제조방법
KR20250137779A (ko) 2024-03-11 2025-09-19 대한민국(농림축산식품부 농림축산검역본부장) Clade 2.3.4.4h에 속하는 재조합 조류 인플루엔자 A 바이러스 합성주, 및 이를 이용한 고병원성 조류 인플루엔자 백신 및 제조방법
US20250288661A1 (en) * 2024-03-13 2025-09-18 Vst Llc Dba Medgene Avian influenza virus vaccines

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5505941A (en) 1981-12-24 1996-04-09 Health Research, Inc. Recombinant avipox virus and method to induce an immune response
US5174993A (en) 1981-12-24 1992-12-29 Health Research Inc. Recombinant avipox virus and immunological use thereof
JP3602530B2 (ja) 1991-03-07 2004-12-15 ヴァイロジェネティクス コーポレイション 遺伝子操作したワクチン菌株
FR2728795B1 (fr) 1994-12-30 1997-03-21 Rhone Merieux Vaccin vivant recombinant aviaire, utilisant comme vecteur un virus herpes aviaire
EP0930893B1 (en) 1996-10-11 2005-04-13 The Regents of The University of California Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
US5980912A (en) 1997-03-25 1999-11-09 Zonagen, Inc. Chitosan induced immunopotentiation
UA84024C2 (ru) 2003-07-24 2008-09-10 Мериал Лимитед Новые вакцинные композиции, которые содержат эмульсию типа "масло в воде"
US7691368B2 (en) 2005-04-15 2010-04-06 Merial Limited Vaccine formulations
US7871626B2 (en) 2005-08-04 2011-01-18 St. Jude Children's Research Hospital Modified influenza virus for monitoring and improving vaccine efficiency
US8202967B2 (en) 2006-10-27 2012-06-19 Boehringer Ingelheim Vetmedica, Inc. H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use
US7910112B2 (en) 2006-11-06 2011-03-22 Merial Limited Feline vaccines against avian influenza
CN101066448A (zh) * 2007-05-25 2007-11-07 扬州大学 重组鸡痘病毒疫苗rFPV－1218AIH5/H9及其构建方法、用途
FR2921387B1 (fr) * 2007-09-26 2012-04-20 Sanofi Pasteur Procede de production du virus de la grippe
WO2010063033A2 (en) * 2008-11-28 2010-06-03 Merial Limited Recombinant avian influenza vaccine and uses thereof
CN101780275A (zh) * 2009-01-21 2010-07-21 中国农业科学院哈尔滨兽医研究所 H5n1亚型禽流感冷适应弱毒活疫苗的研制及其应用
WO2010115133A2 (en) * 2009-04-03 2010-10-07 Merial Limited Newcastle disease virus vectored avian vaccines
EP2419132B1 (en) * 2009-04-15 2014-06-25 Ceva Sante Animale Recombinant avian herpes virus vectors and vaccine for immunizing waterfowl species
SG179037A1 (en) 2009-09-10 2012-04-27 Merial Ltd New vaccine formulations comprising saponin-containing adjuvants
PL2629794T3 (pl) * 2010-10-18 2017-10-31 Intervet Int Bv Szczepionka wektorowa z herpeswirusem indyków przeciwko grypie ptaków u drobiu
EP2444441A1 (en) * 2010-10-19 2012-04-25 Universiteit van Amsterdam Process for preparing foamed polymer
GB2484911B (en) 2010-10-22 2013-04-03 Johnson Matthey Plc NOx absorber catalyst comprising caesium silicate and at least one platinum group metal
PL220281B1 (pl) * 2011-09-23 2015-09-30 Inst Biochemii I Biofizyki Polskiej Akademii Nauk Szczepionka DNA, sposób indukowania odpowiedzi immunologicznej, przeciwciała specyficznie rozpoznające białko hemaglutyniny H5 wirusa grypy i zastosowanie szczepionki DNA
AR089039A1 (es) * 2011-11-30 2014-07-23 Merial Ltd Vectores recombinantes de hvt que expresan antigenos de patogenos de aves y sus usos
JOP20190088A1 (ar) 2016-10-21 2019-04-21 Us Agriculture نواقل مؤتلفة للتعبير عن مولدات مضاد فيروس انفلونزا الطيور و استخداماتها

Also Published As

Publication number Publication date
IL266148B2 (en) 2023-02-01
EP3528842A1 (en) 2019-08-28
IL266148A (en) 2019-06-30
US11058761B2 (en) 2021-07-13
JOP20190088A1 (ar) 2019-04-21
WO2018075977A1 (en) 2018-04-26
EP4378528A3 (en) 2024-12-04
MX385918B (es) 2025-03-18
EP4378528A2 (en) 2024-06-05
KR20190073460A (ko) 2019-06-26
RU2761869C2 (ru) 2021-12-13
ZA201902525B (en) 2020-11-25
RU2019115277A (ru) 2020-11-23
PH12019500854A1 (en) 2019-08-05
MA46580A (fr) 2019-08-28
TN2019000127A1 (en) 2020-10-05
TW201829454A (zh) 2018-08-16
CA3041304A1 (en) 2018-04-26
MY191322A (en) 2022-06-15
CN110072548A (zh) 2019-07-30
SA519401606B1 (ar) 2022-08-25
RU2019115277A3 (es) 2021-03-10
IL266148B (en) 2022-10-01
US20180110852A1 (en) 2018-04-26

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