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MX2019004464A - Cerdos que comprenden cd163 modificada y metodos asociados. - Google Patents

Cerdos que comprenden cd163 modificada y metodos asociados.

Info

Publication number
MX2019004464A
MX2019004464A MX2019004464A MX2019004464A MX2019004464A MX 2019004464 A MX2019004464 A MX 2019004464A MX 2019004464 A MX2019004464 A MX 2019004464A MX 2019004464 A MX2019004464 A MX 2019004464A MX 2019004464 A MX2019004464 A MX 2019004464A
Authority
MX
Mexico
Prior art keywords
swine
modified
domain
associated methods
scavenger
Prior art date
Application number
MX2019004464A
Other languages
English (en)
Inventor
Bruce Alexander Whitelaw Christopher
Geoffrey LILLICO Simon
Archibald Alan
TAIT-BURKARD Christine
Ait-Ali Tahar
Original Assignee
Univ Court Univ Of Edinburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Court Univ Of Edinburgh filed Critical Univ Court Univ Of Edinburgh
Publication of MX2019004464A publication Critical patent/MX2019004464A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a cerdos editados genéticamente que producen la proteína CD163 en la que se ha eliminado el dominio 5 (SRCR5) rico en cisteina del receptor depurador (también conocido como el dominio 5 de CD163); se ha encontrado que tales cerdos están sanos y no exhiben propiedades negativas, y son resistentes a la infección por PRRSV; el CD163 expresado en los cerdos editados también demuestra la retención de la capacidad para funcionar como un depurador de hemoglobina-haptoglobina; tambien se proporcionan métodos para producir tales cerdos.
MX2019004464A 2016-10-17 2017-10-17 Cerdos que comprenden cd163 modificada y metodos asociados. MX2019004464A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1617559.8A GB201617559D0 (en) 2016-10-17 2016-10-17 Swine comprising modified cd163 and associated methods
PCT/EP2017/076460 WO2018073237A1 (en) 2016-10-17 2017-10-17 Swine comprising modified cd163 and associated methods

Publications (1)

Publication Number Publication Date
MX2019004464A true MX2019004464A (es) 2019-09-26

Family

ID=57680765

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019004464A MX2019004464A (es) 2016-10-17 2017-10-17 Cerdos que comprenden cd163 modificada y metodos asociados.

Country Status (12)

Country Link
US (1) US20200045945A1 (es)
EP (1) EP3525581A1 (es)
JP (1) JP2019533445A (es)
KR (1) KR20190067212A (es)
CN (1) CN109862786A (es)
AU (1) AU2017344936A1 (es)
CA (1) CA3037451A1 (es)
GB (1) GB201617559D0 (es)
MX (1) MX2019004464A (es)
PH (1) PH12019500624A1 (es)
RU (1) RU2019110035A (es)
WO (1) WO2018073237A1 (es)

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CN108753832A (zh) * 2018-04-20 2018-11-06 中山大学 一种利用CRISPR/Cas9编辑大白猪CD163基因的方法
CN108823248A (zh) * 2018-04-20 2018-11-16 中山大学 一种利用CRISPR/Cas9编辑陆川猪CD163基因的方法
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US11240997B2 (en) * 2019-04-09 2022-02-08 Shandong Landsee Genetics Co., Ltd. Method for preparing porcine fibroblasts with both CD163 gene and CD13 gene being knocked-out
CN110438155A (zh) * 2019-08-15 2019-11-12 中国农业科学院北京畜牧兽医研究所 修饰cd163基因第561位氨基酸的组合物、应用、细胞及基因编辑猪的制备方法
US11208659B2 (en) * 2020-05-05 2021-12-28 Genus Plc Pig with a genetically modified CD163 gene resistant to PRRSv
EP4157277A4 (en) * 2020-05-29 2024-05-22 University of Connecticut PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS INHIBITORS
CN113512534B (zh) * 2020-09-23 2024-04-23 杭州启函生物科技有限公司 用于遗传修饰和靶向的组合物和方法
CN112094866B (zh) * 2020-11-10 2021-05-11 北京首农未来生物科技有限公司 一种利用SpRY-Cas9系统制备CD163基因编辑猪的方法
CN112877362A (zh) * 2021-02-22 2021-06-01 杭州合欣源生物科技有限公司 构建高繁殖力、抗蓝耳病和系列腹泻病的优质猪核移植供体细胞的基因编辑系统及其应用
CN114774468B (zh) * 2022-04-20 2022-12-20 温氏食品集团股份有限公司 一种等位基因分子标记及抗蓝耳病猪群体组建方法
CN119979720B (zh) * 2025-02-26 2025-09-23 中国农业科学院北京畜牧兽医研究所 猪精液品质相关的分子标记鉴定及其应用

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Also Published As

Publication number Publication date
WO2018073237A1 (en) 2018-04-26
CN109862786A (zh) 2019-06-07
AU2017344936A1 (en) 2019-04-04
PH12019500624A1 (en) 2019-08-19
EP3525581A1 (en) 2019-08-21
KR20190067212A (ko) 2019-06-14
RU2019110035A (ru) 2020-10-05
JP2019533445A (ja) 2019-11-21
GB201617559D0 (en) 2016-11-30
CA3037451A1 (en) 2018-04-26
US20200045945A1 (en) 2020-02-13

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