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MX2019003678A - Enzimas modificadoras de ácido nucleico guiadas por arn y métodos de uso de estas. - Google Patents

Enzimas modificadoras de ácido nucleico guiadas por arn y métodos de uso de estas.

Info

Publication number
MX2019003678A
MX2019003678A MX2019003678A MX2019003678A MX2019003678A MX 2019003678 A MX2019003678 A MX 2019003678A MX 2019003678 A MX2019003678 A MX 2019003678A MX 2019003678 A MX2019003678 A MX 2019003678A MX 2019003678 A MX2019003678 A MX 2019003678A
Authority
MX
Mexico
Prior art keywords
casy
proteins
nucleic acids
acids encoding
rna
Prior art date
Application number
MX2019003678A
Other languages
English (en)
Inventor
Jennifer A Doudna
Jillian F Banfield
David Burstein
Lucas Benjamin Harrington
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of MX2019003678A publication Critical patent/MX2019003678A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C07K2319/00—Fusion polypeptide
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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  • Enzymes And Modification Thereof (AREA)
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Abstract

La presente descripción proporciona proteínas CasY, ácidos nucleicos que codifican las proteínas CasY y células hospedadoras modificadas que comprenden las proteínas CasY y/o ácidos nucleicos que las codifican. Las proteínas CasY son útiles en una variedad de aplicaciones que se proporcionan. La presente descripción proporciona ARN guías de CasY que se unen a y proporcionan especificidad de secuencia a las proteínas CasY, ácidos nucleicos que codifican los ARN guías de CasY y células hospedadoras modificadas que comprenden los ARN guías de CasY y/o ácidos nucleicos que los codifican. Los ARN guías de CasY son útiles en una variedad de aplicaciones que se proporcionan. La presente descripción proporciona métodos para identificar una endonucleasa guiada por ARN de CRISPR.
MX2019003678A 2016-09-30 2017-09-28 Enzimas modificadoras de ácido nucleico guiadas por arn y métodos de uso de estas. MX2019003678A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662402849P 2016-09-30 2016-09-30
PCT/US2017/054047 WO2018064352A1 (en) 2016-09-30 2017-09-28 Rna-guided nucleic acid modifying enzymes and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2019003678A true MX2019003678A (es) 2020-08-13

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MX2019003678A MX2019003678A (es) 2016-09-30 2017-09-28 Enzimas modificadoras de ácido nucleico guiadas por arn y métodos de uso de estas.

Country Status (14)

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US (2) US11371062B2 (es)
EP (1) EP3532089A4 (es)
JP (2) JP7306696B2 (es)
KR (2) KR20190072548A (es)
CN (1) CN110418647B (es)
AU (1) AU2017335883B2 (es)
BR (1) BR112019006388A2 (es)
CA (1) CA3038982A1 (es)
EA (1) EA201990860A1 (es)
GB (1) GB2569734B (es)
IL (1) IL265599A (es)
MX (1) MX2019003678A (es)
SA (1) SA519401442B1 (es)
WO (1) WO2018064352A1 (es)

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