MX2019003298A - Proteinas de union recombinantes y sus usos. - Google Patents
Proteinas de union recombinantes y sus usos.Info
- Publication number
- MX2019003298A MX2019003298A MX2019003298A MX2019003298A MX2019003298A MX 2019003298 A MX2019003298 A MX 2019003298A MX 2019003298 A MX2019003298 A MX 2019003298A MX 2019003298 A MX2019003298 A MX 2019003298A MX 2019003298 A MX2019003298 A MX 2019003298A
- Authority
- MX
- Mexico
- Prior art keywords
- binding proteins
- recombinant binding
- nucleic acids
- proteins
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se desvelan nuevas proteínas de unión recombinantes, que comprenden dominios diseñados con repeticiones de anquirina con especificidad de unión para el HER2, y que comprenden dominios diseñados con repeticiones de anquirina con especificidad de unión para la seroalbúmina, así como los ácidos nucleicos que codifican dichas proteínas de unión recombinantes, composiciones farmacéuticas que comprenden dichas proteínas de unión recombinantes o ácidos nucleicos y el uso de dichas proteínas de unión recombinantes, ácidos nucleicos o composiciones farmacéuticas en el tratamiento de enfermedades.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16190221 | 2016-09-22 | ||
| PCT/EP2017/073768 WO2018054971A1 (en) | 2016-09-22 | 2017-09-20 | Recombinant binding proteins and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019003298A true MX2019003298A (es) | 2019-09-26 |
| MX377424B MX377424B (es) | 2025-03-10 |
Family
ID=57046984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019003298A MX377424B (es) | 2016-09-22 | 2017-09-20 | Proteinas de union recombinantes y sus usos |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US10717772B2 (es) |
| EP (1) | EP3515933B9 (es) |
| JP (1) | JP6976335B2 (es) |
| KR (1) | KR102270315B1 (es) |
| CN (1) | CN109790206A (es) |
| AR (1) | AR109680A1 (es) |
| AU (1) | AU2017331329B2 (es) |
| BR (1) | BR112019005587A2 (es) |
| CA (1) | CA3036301C (es) |
| CL (1) | CL2019000729A1 (es) |
| CO (1) | CO2019002609A2 (es) |
| ES (1) | ES2953516T3 (es) |
| IL (1) | IL265489B (es) |
| MX (1) | MX377424B (es) |
| MY (1) | MY196882A (es) |
| NZ (1) | NZ751689A (es) |
| PH (1) | PH12019500596B1 (es) |
| SA (1) | SA519401369B1 (es) |
| WO (1) | WO2018054971A1 (es) |
| ZA (1) | ZA201901592B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12021553000A1 (en) * | 2019-06-04 | 2023-08-23 | Molecular Partners Ag | Multispecific proteins |
| CN114206908B (zh) | 2019-06-04 | 2025-12-23 | 分子伴侣公司 | 具有改善的稳定性的经设计的锚蛋白重复结构域 |
| AU2020286600A1 (en) * | 2019-06-04 | 2021-12-23 | Molecular Partners Ag | Recombinant FAP binding proteins and their use |
| JP2022535107A (ja) * | 2019-06-04 | 2022-08-04 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 組換え４－１ｂｂ結合タンパク質及びそれらの使用 |
| BR112022011456A2 (pt) | 2019-12-11 | 2022-08-23 | Molecular Partners Ag | Proteínas recombinantes de ligação a complexo de peptídeo-mhc e geração e uso das mesmas |
| CA3176845A1 (en) | 2020-05-06 | 2021-11-11 | Patrick AMSTUTZ | Novel ankyrin repeat binding proteins and their uses |
| JP2023528207A (ja) * | 2020-05-14 | 2023-07-04 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 組換えｃｄ４０結合タンパク質及びそれらの使用 |
| EP4149959A1 (en) | 2020-05-14 | 2023-03-22 | Molecular Partners AG | Multispecific proteins |
| EP4263607A1 (en) | 2020-12-16 | 2023-10-25 | Molecular Partners AG | Novel slow-release prodrugs |
| US20240317852A1 (en) | 2021-03-09 | 2024-09-26 | Molecular Partners Ag | Novel darpin based cd33 engagers |
| EP4304729A1 (en) | 2021-03-09 | 2024-01-17 | Molecular Partners AG | Novel darpin based cd123 engagers |
| US11834504B2 (en) | 2021-03-09 | 2023-12-05 | Molecular Partners Ag | DARPin based multi-specific t-cell engagers |
| CA3211242A1 (en) | 2021-03-09 | 2022-09-15 | Molecular Partners Ag | Protease cleavable prodrugs |
| AU2022413461A1 (en) | 2021-12-14 | 2024-06-06 | Molecular Partners Ag | Designed repeat domains with dual binding specificity and their use |
| IL318514A (en) | 2022-08-01 | 2025-03-01 | Molecular Partners Ag | Loading and using modified re-designed websites |
| WO2024038307A1 (en) | 2022-08-19 | 2024-02-22 | Novartis Ag | Dosing regimens for sars-cov-2 binding molecules |
| AU2024221136A1 (en) | 2023-02-17 | 2025-10-02 | Ablynx N.V. | Polypeptides binding to the neonatal fc receptor |
| WO2024179981A1 (en) | 2023-02-27 | 2024-09-06 | Molecular Partners Ag | Darpins for use in reducing renal accumulation of drugs |
| WO2024251628A1 (en) | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd16a binding proteins and their use |
| AU2024286934A1 (en) | 2023-06-06 | 2025-12-18 | Molecular Partners Ag | Recombinant cd2 binding proteins and their use |
| WO2025146487A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Multispecific binding proteins |
| WO2025146491A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent |
| WO2025163144A1 (en) | 2024-01-31 | 2025-08-07 | Molecular Partners Ag | Recombinant mesothelin binding proteins and their use |
| WO2025181039A1 (en) | 2024-03-01 | 2025-09-04 | Molecular Partners Ag | Therapeutic combinations comprising a multi-specific t cell engager |
| WO2026013280A1 (en) * | 2024-07-11 | 2026-01-15 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Designed ankyrin repeat proteins binding p53, and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| US7371376B1 (en) | 1996-10-18 | 2008-05-13 | Genentech, Inc. | Anti-ErbB2 antibodies |
| ATE448301T1 (de) | 2000-09-08 | 2009-11-15 | Univ Zuerich | Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten |
| EP1567641B1 (en) * | 2001-08-24 | 2012-05-23 | UVic Industry Partnerships Inc. | Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer |
| NZ554429A (en) | 2004-11-12 | 2010-08-27 | Bayer Schering Pharma Ag | Recombinant newcastle disease virus comprising a transgene encoding a antibody or antibody like fragment or derivative thereof for use in cancer treatments |
| AU2006268780B2 (en) | 2005-07-08 | 2011-03-24 | University Of Zurich | Phage display using cotranslational translocation of fusion polypeptides |
| JP2010539915A (ja) | 2007-09-24 | 2010-12-24 | ユニバーシティ・オブ・チューリッヒ | 設計されたアルマジロリピートタンパク質 |
| MX2010005783A (es) | 2007-11-27 | 2010-08-10 | Ablynx Nv | Secuencias de aminoacidos dirigidas contra citoquinas heterodimericas y/o sus receptores y polipeptidos que comprenden las mismas. |
| BRPI0921469B1 (pt) | 2008-11-03 | 2022-01-18 | Molecular Partners Ag | Proteínas de ligação que inibem a interação com o receptor de vegf-a, composição farmacêutica |
| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| EP2643349B1 (en) * | 2010-11-26 | 2019-09-04 | Molecular Partners AG | Designed repeat proteins binding to serum albumin |
| EA201391607A1 (ru) | 2011-04-29 | 2014-04-30 | Янссен Байотек, Инк. | Связывающие il4/il13 белки с повторами и их применение |
| HK1209156A1 (en) | 2012-06-28 | 2016-03-24 | 分子伴侣公司 | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
| US10093740B2 (en) * | 2012-10-15 | 2018-10-09 | Universitat Zurich | Bispecific HER2 ligands for cancer therapy |
| EP2738180A1 (en) * | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| JP6486908B2 (ja) | 2013-05-31 | 2019-03-20 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 肝細胞増殖因子に結合する設計アンキリン反復タンパク質 |
| PH12017501792B1 (en) | 2015-04-02 | 2022-07-20 | Molecular Partners Ag | Recombinant binding proteins and their use |
-
2017
- 2017-09-20 AR ARP170102593A patent/AR109680A1/es not_active Application Discontinuation
- 2017-09-20 CA CA3036301A patent/CA3036301C/en active Active
- 2017-09-20 AU AU2017331329A patent/AU2017331329B2/en not_active Ceased
- 2017-09-20 US US15/710,001 patent/US10717772B2/en active Active
- 2017-09-20 KR KR1020197009396A patent/KR102270315B1/ko not_active Expired - Fee Related
- 2017-09-20 CN CN201780058511.0A patent/CN109790206A/zh active Pending
- 2017-09-20 BR BR112019005587A patent/BR112019005587A2/pt not_active Application Discontinuation
- 2017-09-20 ES ES17778226T patent/ES2953516T3/es active Active
- 2017-09-20 WO PCT/EP2017/073768 patent/WO2018054971A1/en not_active Ceased
- 2017-09-20 JP JP2019536693A patent/JP6976335B2/ja not_active Expired - Fee Related
- 2017-09-20 MY MYPI2019001523A patent/MY196882A/en unknown
- 2017-09-20 NZ NZ751689A patent/NZ751689A/en not_active IP Right Cessation
- 2017-09-20 MX MX2019003298A patent/MX377424B/es active IP Right Grant
- 2017-09-20 EP EP17778226.5A patent/EP3515933B9/en active Active
- 2017-09-20 PH PH1/2019/500596A patent/PH12019500596B1/en unknown
-
2019
- 2019-03-14 ZA ZA2019/01592A patent/ZA201901592B/en unknown
- 2019-03-19 IL IL265489A patent/IL265489B/en unknown
- 2019-03-20 SA SA519401369A patent/SA519401369B1/ar unknown
- 2019-03-21 CL CL2019000729A patent/CL2019000729A1/es unknown
- 2019-03-21 CO CONC2019/0002609A patent/CO2019002609A2/es unknown
-
2020
- 2020-06-22 US US16/907,415 patent/US20210130420A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |