MX2019002675A - Formulaciones de buprenorfina de liberacion sostenida. - Google Patents
Formulaciones de buprenorfina de liberacion sostenida.Info
- Publication number
- MX2019002675A MX2019002675A MX2019002675A MX2019002675A MX2019002675A MX 2019002675 A MX2019002675 A MX 2019002675A MX 2019002675 A MX2019002675 A MX 2019002675A MX 2019002675 A MX2019002675 A MX 2019002675A MX 2019002675 A MX2019002675 A MX 2019002675A
- Authority
- MX
- Mexico
- Prior art keywords
- butanol
- organic solvent
- sustained
- acyl
- alkylcarbonyl group
- Prior art date
Links
- 229960001736 buprenorphine Drugs 0.000 title abstract 2
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000013268 sustained release Methods 0.000 title 1
- 239000012730 sustained-release form Substances 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 abstract 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical group CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 abstract 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 abstract 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 abstract 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229960002903 benzyl benzoate Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 239000007972 injectable composition Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Una composición farmacéuticamente inyectable que incluye una solución de 3-acil-buprenorfina o una sal farmacéuticamente aceptable de la misma, en un solvente orgánico biocompatible, en donde la composición farmacéutica inyectable exhibe un perfil de liberación estable que se mantiene durante una semana cuando se inyecta a un paciente. El grupo acilo es un grupo alquilcarbonilo, en donde una porción alquilo del grupo alquilcarbonilo es una cadena lineal o una cadena ramificada, que tiene 1-20 átomos de carbono. El solvente orgánico biocompatible es Nmetil-2-pirrolidona, acetato de etilo, etanol, butanol, 2-butanol, isobutanol, isopropanol, glicerina, benzoato de bencilo,dimetilsulfóxido, N,N-dimetilacetamida, propilenglicol, dimetilglicol, alcohol bencílico o una combinación de dos o más de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662394168P | 2016-09-13 | 2016-09-13 | |
| PCT/CN2017/101327 WO2018050043A1 (en) | 2016-09-13 | 2017-09-12 | Sustained-release buprenorphine formulations background of invention |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019002675A true MX2019002675A (es) | 2019-08-01 |
| MX374304B MX374304B (es) | 2025-03-06 |
Family
ID=61619029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019002675A MX374304B (es) | 2016-09-13 | 2017-09-12 | Formulaciones de buprenorfina de liberación sostenida. |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US10744132B2 (es) |
| EP (1) | EP3512518B1 (es) |
| JP (1) | JP6929367B2 (es) |
| KR (1) | KR102244500B1 (es) |
| CN (1) | CN109789137B (es) |
| AR (1) | AR110468A1 (es) |
| AU (1) | AU2017325910B2 (es) |
| BR (1) | BR112019004923A2 (es) |
| CA (1) | CA3033046C (es) |
| CL (1) | CL2019000624A1 (es) |
| CO (1) | CO2019003632A2 (es) |
| DK (1) | DK3512518T3 (es) |
| ES (1) | ES2934721T3 (es) |
| FI (1) | FI3512518T3 (es) |
| HR (1) | HRP20230062T8 (es) |
| HU (1) | HUE060906T2 (es) |
| LT (1) | LT3512518T (es) |
| MX (1) | MX374304B (es) |
| MY (1) | MY196269A (es) |
| PE (1) | PE20190707A1 (es) |
| PH (1) | PH12019500466A1 (es) |
| PL (1) | PL3512518T3 (es) |
| PT (1) | PT3512518T (es) |
| RS (1) | RS63894B1 (es) |
| RU (1) | RU2747306C2 (es) |
| SG (1) | SG11201901294QA (es) |
| SI (1) | SI3512518T1 (es) |
| SM (1) | SMT202300006T1 (es) |
| TW (1) | TWI743193B (es) |
| WO (1) | WO2018050043A1 (es) |
| ZA (1) | ZA201900890B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1057075C (zh) * | 1997-09-10 | 2000-10-04 | 中国石油化工总公司 | 低碳烯烃直接水合连续生产低碳醇的方法 |
| EP3790881A4 (en) * | 2018-05-11 | 2022-03-09 | Alar Pharmaceuticals Inc. | LONG-ACTING INJECTABLE FORMULATIONS AND CRYSTALLINE FORMS OF BUPRENORPHINE DERIVATIVES |
| BR112021012210A2 (pt) * | 2018-12-27 | 2021-08-31 | Alar Pharmaceuticals Inc. | Formulação injetável de liberação sustentada de naltrexona |
| EP3936112A1 (en) * | 2020-07-07 | 2022-01-12 | Occlugel | Hydrophilic degradable microspheres for delivering buprenorphine |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2382577C (en) | 1999-08-27 | 2008-01-22 | Southern Research Institute | Injectable buprenorphine microparticle compositions and their use |
| EP1554290B1 (en) | 2002-10-25 | 2009-09-30 | Euro-Celtique S.A. | Analogs and prodrugs of buprenorphine |
| TWI226830B (en) * | 2002-11-12 | 2005-01-21 | Chi Mei Foundation Medical Ct | Novel ester derivatives of buprenorphine and their preparation processes, and long acting analgesic pharmaceutical compositions |
| CN1263760C (zh) * | 2002-11-12 | 2006-07-12 | 财团法人奇美医院 | 新颖的丁丙诺啡酯衍生物及其制备方法，以及长效作用镇痛药学组合物 |
| ATE382050T1 (de) | 2002-11-25 | 2008-01-15 | Chi Mei Foundation Medical Ct | Buprenorphinesterderivate, verfahren zu ihrer herstellung, und langwirksame analgetische arzneimittel |
| ATE401054T1 (de) | 2004-06-04 | 2008-08-15 | Camurus Ab | Flüssige depotformulierungen |
| KR20080071185A (ko) * | 2005-11-21 | 2008-08-01 | 쉐링-프라우 리미티드 | 부프레노르핀을 포함하는 약제학적 조성물 |
| GB0606124D0 (en) * | 2006-03-28 | 2006-05-03 | Reckitt Benckiser Healthcare | Buprenorphine derivatives and uses thereof |
| US7511054B2 (en) * | 2006-09-22 | 2009-03-31 | Alltranz Inc. | Transdermally deliverable opioid prodrugs, abuse-resistant compositions and methods of using opioid prodrugs |
| US20090181068A1 (en) * | 2008-01-14 | 2009-07-16 | Dunn Richard L | Low Viscosity Liquid Polymeric Delivery System |
| GB2481018B (en) | 2010-06-08 | 2015-03-18 | Rb Pharmaceuticals Ltd | Injectable flowable composition comprising buprenorphine |
| GB2513060B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
| FR2975912B1 (fr) | 2011-05-30 | 2013-06-14 | Flamel Tech Sa | Composition a liberation controlee de buprenorphine |
| US9393211B2 (en) | 2013-03-15 | 2016-07-19 | Oakwood Laboratories LLC | High drug load buprenorphine microspheres and method of producing same |
| GB201404139D0 (en) * | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
| GB201419091D0 (en) * | 2014-10-27 | 2014-12-10 | Camurus Ab | Formulations |
-
2017
- 2017-09-12 MY MYPI2019000910A patent/MY196269A/en unknown
- 2017-09-12 AU AU2017325910A patent/AU2017325910B2/en active Active
- 2017-09-12 DK DK17850245.6T patent/DK3512518T3/da active
- 2017-09-12 PT PT178502456T patent/PT3512518T/pt unknown
- 2017-09-12 CA CA3033046A patent/CA3033046C/en active Active
- 2017-09-12 JP JP2019535434A patent/JP6929367B2/ja active Active
- 2017-09-12 RS RS20230034A patent/RS63894B1/sr unknown
- 2017-09-12 SM SM20230006T patent/SMT202300006T1/it unknown
- 2017-09-12 SI SI201731295T patent/SI3512518T1/sl unknown
- 2017-09-12 HU HUE17850245A patent/HUE060906T2/hu unknown
- 2017-09-12 LT LTEPPCT/CN2017/101327T patent/LT3512518T/lt unknown
- 2017-09-12 RU RU2019102895A patent/RU2747306C2/ru active
- 2017-09-12 MX MX2019002675A patent/MX374304B/es active IP Right Grant
- 2017-09-12 EP EP17850245.6A patent/EP3512518B1/en active Active
- 2017-09-12 HR HRP20230062TT patent/HRP20230062T8/hr unknown
- 2017-09-12 TW TW106131215A patent/TWI743193B/zh active
- 2017-09-12 SG SG11201901294QA patent/SG11201901294QA/en unknown
- 2017-09-12 FI FIEP17850245.6T patent/FI3512518T3/fi active
- 2017-09-12 BR BR112019004923A patent/BR112019004923A2/pt not_active Application Discontinuation
- 2017-09-12 KR KR1020197009185A patent/KR102244500B1/ko active Active
- 2017-09-12 CN CN201780055635.3A patent/CN109789137B/zh active Active
- 2017-09-12 PE PE2019000487A patent/PE20190707A1/es unknown
- 2017-09-12 WO PCT/CN2017/101327 patent/WO2018050043A1/en not_active Ceased
- 2017-09-12 PL PL17850245.6T patent/PL3512518T3/pl unknown
- 2017-09-12 US US16/098,864 patent/US10744132B2/en active Active
- 2017-09-12 ES ES17850245T patent/ES2934721T3/es active Active
- 2017-09-13 AR ARP170102519A patent/AR110468A1/es not_active Application Discontinuation
-
2019
- 2019-02-12 ZA ZA2019/00890A patent/ZA201900890B/en unknown
- 2019-03-01 PH PH12019500466A patent/PH12019500466A1/en unknown
- 2019-03-12 CL CL2019000624A patent/CL2019000624A1/es unknown
- 2019-04-11 CO CONC2019/0003632A patent/CO2019003632A2/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |