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MX2019001767A - Anticuerpos monoclonales que se unen al dominio de union a lipidos de la proteina de la capside del virus de la hepatitis c (vhc). - Google Patents

Anticuerpos monoclonales que se unen al dominio de union a lipidos de la proteina de la capside del virus de la hepatitis c (vhc).

Info

Publication number
MX2019001767A
MX2019001767A MX2019001767A MX2019001767A MX2019001767A MX 2019001767 A MX2019001767 A MX 2019001767A MX 2019001767 A MX2019001767 A MX 2019001767A MX 2019001767 A MX2019001767 A MX 2019001767A MX 2019001767 A MX2019001767 A MX 2019001767A
Authority
MX
Mexico
Prior art keywords
binding domain
monoclonal antibodies
lipid binding
hcv core
antibodies
Prior art date
Application number
MX2019001767A
Other languages
English (en)
Inventor
A Muerhoff Scott
Marohnic Christopher
Ziemann Robert
Ahlberg April
Hawksworth David
Tieman Bryan
Otis Kathy
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX2019001767A publication Critical patent/MX2019001767A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • C07K16/118—
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae
    • G01N2333/183—Flaviviridae, e.g. pestivirus, mucosal disease virus, bovine viral diarrhoea virus, classical swine fever virus (hog cholera virus) or border disease virus
    • G01N2333/186—Hepatitis C; Hepatitis NANB
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Tropical Medicine & Parasitology (AREA)

Abstract

Se proveen anticuerpos monoclonales para la detección de antígenos del virus de la hepatitis C (VHC). Los anticuerpos son específicamente inmunorreactivos con al menos un epítopo del dominio de unión de lípido de los residuos de aminoácido 134-171 del antígeno de núcleo de VHC. Se proveen además métodos de inmunoensayo para usar anticuerpos, kits y composiciones que comprenden los anticuerpos para detectar la infección por VHC.
MX2019001767A 2013-03-14 2015-09-14 Anticuerpos monoclonales que se unen al dominio de union a lipidos de la proteina de la capside del virus de la hepatitis c (vhc). MX2019001767A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361783529P 2013-03-14 2013-03-14

Publications (1)

Publication Number Publication Date
MX2019001767A true MX2019001767A (es) 2019-06-17

Family

ID=51528692

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015012825A MX376492B (es) 2013-03-14 2013-12-23 Anticuerpos monoclonares que se unen al dominio de unión a lípidos de la proteína de la cápside del virus de la hepatitis c (vhc)
MX2019001767A MX2019001767A (es) 2013-03-14 2015-09-14 Anticuerpos monoclonales que se unen al dominio de union a lipidos de la proteina de la capside del virus de la hepatitis c (vhc).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015012825A MX376492B (es) 2013-03-14 2013-12-23 Anticuerpos monoclonares que se unen al dominio de unión a lípidos de la proteína de la cápside del virus de la hepatitis c (vhc)

Country Status (7)

Country Link
US (7) US9371374B2 (es)
EP (3) EP3564384A1 (es)
JP (2) JP6739329B2 (es)
CN (2) CN105378099B (es)
CA (1) CA2906417C (es)
MX (2) MX376492B (es)
WO (1) WO2014143343A1 (es)

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