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MX2019001302A - Conjugados de farmaco con enlazadores autoestabilizantes que tienen propiedades fisioquimicas mejoradas. - Google Patents

Conjugados de farmaco con enlazadores autoestabilizantes que tienen propiedades fisioquimicas mejoradas.

Info

Publication number
MX2019001302A
MX2019001302A MX2019001302A MX2019001302A MX2019001302A MX 2019001302 A MX2019001302 A MX 2019001302A MX 2019001302 A MX2019001302 A MX 2019001302A MX 2019001302 A MX2019001302 A MX 2019001302A MX 2019001302 A MX2019001302 A MX 2019001302A
Authority
MX
Mexico
Prior art keywords
self
drug conjugates
physiochemical properties
improved physiochemical
stabilizing linkers
Prior art date
Application number
MX2019001302A
Other languages
English (en)
Inventor
Moquist Philip
Original Assignee
Seattle Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seattle Genetics Inc filed Critical Seattle Genetics Inc
Publication of MX2019001302A publication Critical patent/MX2019001302A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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  • Animal Behavior & Ethology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
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  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Peptides Or Proteins (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)

Abstract

Se describen compuestos y composiciones en los cuales una unidad de fármaco está ligada a una unidad de ligando de direccionamiento mediante una unidad de enlazador autoestabilizante a partir de la cual se libera un compuesto de fármaco o una porción de fármaco activo hacia el sitio de acción diana. También se describen métodos para el tratamiento de enfermedades caracterizadas por las células anormales diana, tales como el cáncer o una enfermedad autoinmunitaria, a través del uso de los compuestos y composiciones de la invención.
MX2019001302A 2016-08-09 2017-08-09 Conjugados de farmaco con enlazadores autoestabilizantes que tienen propiedades fisioquimicas mejoradas. MX2019001302A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662372455P 2016-08-09 2016-08-09
PCT/US2017/046157 WO2018031690A1 (en) 2016-08-09 2017-08-09 Drug conjugates with self-stabilizing linkers having improved physiochemical properties

Publications (1)

Publication Number Publication Date
MX2019001302A true MX2019001302A (es) 2019-06-12

Family

ID=61162990

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019001302A MX2019001302A (es) 2016-08-09 2017-08-09 Conjugados de farmaco con enlazadores autoestabilizantes que tienen propiedades fisioquimicas mejoradas.
MX2023013592A MX2023013592A (es) 2016-08-09 2023-12-13 Conjugados de farmaco con enlazadores autoestabilizantes que tienen propiedades fisioquimicas mejoradas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023013592A MX2023013592A (es) 2016-08-09 2023-12-13 Conjugados de farmaco con enlazadores autoestabilizantes que tienen propiedades fisioquimicas mejoradas.

Country Status (14)

Country Link
US (2) US11944689B2 (es)
EP (1) EP3496747A4 (es)
JP (2) JP7257951B2 (es)
KR (2) KR20190038579A (es)
CN (1) CN109562152B (es)
AU (2) AU2017310436B2 (es)
BR (1) BR112019001945A2 (es)
EA (1) EA201990470A1 (es)
IL (1) IL264453A (es)
MA (1) MA45945A (es)
MX (2) MX2019001302A (es)
SG (1) SG11201900699QA (es)
TW (2) TW202500191A (es)
WO (1) WO2018031690A1 (es)

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