MX2019000527A - Inhibidores de cinasa dependiente de ciclina 7 (cdk7). - Google Patents
Inhibidores de cinasa dependiente de ciclina 7 (cdk7).Info
- Publication number
- MX2019000527A MX2019000527A MX2019000527A MX2019000527A MX2019000527A MX 2019000527 A MX2019000527 A MX 2019000527A MX 2019000527 A MX2019000527 A MX 2019000527A MX 2019000527 A MX2019000527 A MX 2019000527A MX 2019000527 A MX2019000527 A MX 2019000527A
- Authority
- MX
- Mexico
- Prior art keywords
- subject
- diseases
- cdk7
- dependent kinase
- cycline
- Prior art date
Links
- XEIVCDDCSGGZSG-UHFFFAOYSA-N 7-[3-[(3-formylphenoxy)methyl]-1,5-dimethylpyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1H-indole-2-carboxylic acid Chemical compound Cc1c(c(COc2cccc(C=O)c2)nn1C)-c1cccc2c(CCCOc3cccc4ccccc34)c([nH]c12)C(O)=O XEIVCDDCSGGZSG-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 102100026810 Cyclin-dependent kinase 7 Human genes 0.000 abstract 2
- 101710106276 Cyclin-dependent kinase 7 Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002062 proliferating effect Effects 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000011594 Autoinflammatory disease Diseases 0.000 abstract 1
- 206010060999 Benign neoplasm Diseases 0.000 abstract 1
- 208000034578 Multiple myelomas Diseases 0.000 abstract 1
- 206010035226 Plasma cell myeloma Diseases 0.000 abstract 1
- 230000001594 aberrant effect Effects 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente invención proporciona nuevos compuestos de la Fórmula (I) y sales, solvatos, hidratos, tautómeros, estereoisómeros, derivados etiquetados isotópicamente y composiciones farmacéuticamente aceptables de los mismos. También se proporcionan métodos y kits que incluyen los compuestos o composiciones para tratar o prevenir enfermedades proliferativas (por ejemplo, cánceres (por ejemplo, leucemia, melanoma, mieloma múltiple), neoplasias benignas, angiogénesis, enfermedades inflamatorias, enfermedades autoinflamatorias y enfermedades autoinmunes) en un sujeto. El tratamiento de un sujeto con una enfermedad proliferativa usando un compuesto o composición de la invención puede inhibir la actividad aberrante de la cinasa dependiente de ciclina 7 (CDK7) y, por lo tanto, inducir la apoptosis celular y/o inhibir la transcripción en el sujeto.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662361852P | 2016-07-13 | 2016-07-13 | |
| PCT/US2017/042017 WO2018013867A1 (en) | 2016-07-13 | 2017-07-13 | Inhibitors of cyclin dependnt kinase 7 (cdk7) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019000527A true MX2019000527A (es) | 2019-08-12 |
| MX392308B MX392308B (es) | 2025-03-24 |
Family
ID=59501528
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019000527A MX392308B (es) | 2016-07-13 | 2017-07-13 | Inhibidores de cinasa dependiente de ciclina 7 (cdk7). |
| MX2022005898A MX2022005898A (es) | 2016-07-13 | 2019-01-11 | Inhibidores de cinasa dependiente de ciclina 7 (cdk7). |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022005898A MX2022005898A (es) | 2016-07-13 | 2019-01-11 | Inhibidores de cinasa dependiente de ciclina 7 (cdk7). |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20230062491A1 (es) |
| EP (2) | EP3484871B1 (es) |
| JP (2) | JP7058636B2 (es) |
| KR (1) | KR102587758B1 (es) |
| CN (1) | CN110036004A (es) |
| AU (2) | AU2017295863B2 (es) |
| BR (1) | BR112019000716A2 (es) |
| CA (1) | CA3030795A1 (es) |
| ES (1) | ES2954278T3 (es) |
| IL (2) | IL264222B (es) |
| MX (2) | MX392308B (es) |
| RU (1) | RU2019103870A (es) |
| SG (2) | SG11201900328WA (es) |
| WO (1) | WO2018013867A1 (es) |
| ZA (2) | ZA201900874B (es) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10913983B2 (en) | 2017-07-18 | 2021-02-09 | University Of South Carolina | Sensitivity markers and uses for CDK7 inhibitors in breast cancers |
| AU2019209475A1 (en) | 2018-01-16 | 2020-08-20 | Syros Pharmaceuticals, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
| US11311542B2 (en) | 2018-01-16 | 2022-04-26 | Syros Pharmaceuticals, Inc. | Inhibitors of cyclin dependent kinase 7 (CDK7) |
| PE20201202A1 (es) * | 2018-04-26 | 2020-11-11 | Pfizer | Inhibidores de cinasa dependientes de ciclina |
| JP2021151955A (ja) * | 2018-05-22 | 2021-09-30 | 株式会社カネカ | 光学活性−ｃｉｓ−アミノピペリジンの製造方法 |
| CN109206427A (zh) * | 2018-09-25 | 2019-01-15 | 安徽医科大学 | 芳香杂环乙烯基吡唑并嘧啶类化合物、药物制剂及制备方法与应用 |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| TWI835909B (zh) * | 2018-11-01 | 2024-03-21 | 美商錫羅斯製藥公司 | 週期素依賴性激酶7(cdk7)之抑制劑 |
| JP2022515705A (ja) | 2018-11-01 | 2022-02-22 | サイロス ファーマシューティカルズ， インコーポレイテッド | サイクリン依存性キナーゼ７（ｃｄｋ７）の非共有結合性阻害剤を用いてバイオマーカーにより特定された患者におけるがんを処置する方法 |
| US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| CA3132387A1 (en) * | 2019-04-23 | 2020-10-29 | Dana-Farber Cancer Institute, Inc. | Degraders of cyclin-dependent kinase 12 (cdk12) and uses thereof |
| WO2020223469A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| AU2020328025A1 (en) * | 2019-08-14 | 2022-03-03 | Incyte Corporation | Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors |
| CN112430208A (zh) * | 2019-08-26 | 2021-03-02 | 东莞市东阳光仿制药研发有限公司 | 一种pf-06651600中间体的制备方法 |
| CN119930611A (zh) | 2019-10-11 | 2025-05-06 | 因赛特公司 | 作为cdk2抑制剂的双环胺 |
| CN114901284A (zh) * | 2019-10-29 | 2022-08-12 | 希洛斯医药品股份有限公司 | 用细胞周期蛋白依赖性激酶7(cdk7)抑制剂治疗生物标志物鉴定的患者的癌症的方法 |
| CN111393415B (zh) * | 2020-04-30 | 2020-11-20 | 苏州信诺维医药科技有限公司 | 一种杂芳腈类化合物及其应用 |
| WO2021243280A2 (en) * | 2020-05-29 | 2021-12-02 | Syros Pharmaceuticals, Inc. | Methods of treating cancer in patients with an anomalous kras gene or deletions within chromosome 9 |
| CN111675708A (zh) * | 2020-06-10 | 2020-09-18 | 南京合巨药业有限公司 | 一种6-氰基-7-氮杂吲哚及其衍生物的制备方法 |
| CN112661745A (zh) * | 2020-07-24 | 2021-04-16 | 浙江同源康医药股份有限公司 | 用作cdk7激酶抑制剂的化合物及其应用 |
| CN114133394B (zh) * | 2020-08-12 | 2023-12-08 | 赛诺哈勃药业（成都）有限公司 | 一种选择性针对细胞周期依赖性激酶12活性的化合物、制备方法及医药用途 |
| SI4214202T1 (sl) * | 2020-09-15 | 2025-05-30 | Pfizer Inc. | Trdne oblike inhibitorja cdk4 |
| CN114249712A (zh) * | 2020-09-24 | 2022-03-29 | 广州费米子科技有限责任公司 | 嘧啶基衍生物、其制备方法及其用途 |
| WO2022089444A1 (zh) * | 2020-10-28 | 2022-05-05 | 恒元生物医药科技(苏州)有限公司 | 一种含氮杂环化合物及其应用 |
| KR20230128304A (ko) * | 2020-12-24 | 2023-09-04 | 지티 아페이론 테라퓨틱스 리미티드 | 방향족 이종고리 화합물, 약학 조성물 및 이의 용도 |
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| CN117384135A (zh) * | 2022-07-04 | 2024-01-12 | 浙江同源康医药股份有限公司 | 用作cdk7激酶抑制剂的化合物及其应用 |
| CN118176189B (zh) * | 2022-07-08 | 2025-10-28 | 成都苑东生物制药股份有限公司 | 一种嘧啶类衍生物、其制备方法及用途 |
| AU2023370363A1 (en) | 2022-10-25 | 2025-04-24 | Tuojie Biotech (Shanghai) Co., Ltd. | Piperidinopyrimidine derivative, preparation method therefor and use thereof in medicine |
| CN118206535A (zh) * | 2022-12-16 | 2024-06-18 | 杭州阿诺生物医药科技有限公司 | 细胞周期蛋白k降解剂及其应用 |
| CN115819406B (zh) * | 2023-02-24 | 2023-06-02 | 淄博百极荣创医药科技有限公司 | 3-(4-嘧啶)-1h-吲哚类化合物的合成方法 |
| CN116082337B (zh) * | 2023-03-16 | 2023-06-23 | 英矽智能科技(上海)有限公司 | 炔基取代的杂环化合物，其制法与医药上的用途 |
| WO2024255845A1 (zh) * | 2023-06-14 | 2024-12-19 | 中国科学院上海药物研究所 | 一类蛋白降解剂及其药物组合物和用途 |
| CN120813579A (zh) * | 2023-06-19 | 2025-10-17 | 英矽智能科技(上海)有限公司 | 大环类化合物的合成及其在医药上的用途 |
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2017
- 2017-07-13 EP EP17746235.5A patent/EP3484871B1/en active Active
- 2017-07-13 ES ES17746235T patent/ES2954278T3/es active Active
- 2017-07-13 WO PCT/US2017/042017 patent/WO2018013867A1/en not_active Ceased
- 2017-07-13 SG SG11201900328WA patent/SG11201900328WA/en unknown
- 2017-07-13 KR KR1020197004222A patent/KR102587758B1/ko active Active
- 2017-07-13 BR BR112019000716A patent/BR112019000716A2/pt not_active Application Discontinuation
- 2017-07-13 CA CA3030795A patent/CA3030795A1/en active Pending
- 2017-07-13 MX MX2019000527A patent/MX392308B/es unknown
- 2017-07-13 SG SG10202012466PA patent/SG10202012466PA/en unknown
- 2017-07-13 CN CN201780057760.8A patent/CN110036004A/zh active Pending
- 2017-07-13 RU RU2019103870A patent/RU2019103870A/ru unknown
- 2017-07-13 AU AU2017295863A patent/AU2017295863B2/en active Active
- 2017-07-13 EP EP23177402.7A patent/EP4295852A3/en not_active Withdrawn
- 2017-07-13 JP JP2019502013A patent/JP7058636B2/ja active Active
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2019
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2021
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2022
- 2022-02-08 US US17/667,288 patent/US20230062491A1/en not_active Abandoned
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2023
- 2023-02-10 ZA ZA2023/01672A patent/ZA202301672B/en unknown
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2024
- 2024-04-15 US US18/635,402 patent/US20240360165A1/en active Pending
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