[go: up one dir, main page]

MX2019000429A - Anticuerpo dirigido contra s100a9 humanizado y usos del mismo. - Google Patents

Anticuerpo dirigido contra s100a9 humanizado y usos del mismo.

Info

Publication number
MX2019000429A
MX2019000429A MX2019000429A MX2019000429A MX2019000429A MX 2019000429 A MX2019000429 A MX 2019000429A MX 2019000429 A MX2019000429 A MX 2019000429A MX 2019000429 A MX2019000429 A MX 2019000429A MX 2019000429 A MX2019000429 A MX 2019000429A
Authority
MX
Mexico
Prior art keywords
receptor
antibody
humanized anti
tlr2
toll
Prior art date
Application number
MX2019000429A
Other languages
English (en)
Inventor
Sulea Traian
Tessier Philippe
Tardif Mélanie
Original Assignee
Univ Laval
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Laval filed Critical Univ Laval
Publication of MX2019000429A publication Critical patent/MX2019000429A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se proporciona un inhibidor del receptor tipo Toll 2 (TLR2) que bloquea específicamente una interacción entre S1009A y el receptor tipo Toll 2 (TLR2) y, más particularmente, un anticuerpo humanizado contra la proteína S100A9 para inhibir y tratar afecciones inflamatorias en un paciente humano. Particularmente, este anticuerpo humanizado es específico para bloquear la interacción entre la proteína S100A9 y el receptor TLR-2.
MX2019000429A 2015-07-13 2016-07-11 Anticuerpo dirigido contra s100a9 humanizado y usos del mismo. MX2019000429A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562191733P 2015-07-13 2015-07-13
PCT/CA2016/050810 WO2017008153A1 (en) 2015-07-13 2016-07-11 Humanized anti-s100a9 antibody and uses thereof

Publications (1)

Publication Number Publication Date
MX2019000429A true MX2019000429A (es) 2019-06-10

Family

ID=57756600

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019000429A MX2019000429A (es) 2015-07-13 2016-07-11 Anticuerpo dirigido contra s100a9 humanizado y usos del mismo.

Country Status (10)

Country Link
US (1) US11359010B2 (es)
EP (1) EP3481863A4 (es)
JP (1) JP6953033B2 (es)
KR (1) KR102234279B1 (es)
CN (1) CN109641951A (es)
AU (1) AU2016293391B2 (es)
BR (1) BR112019000635A2 (es)
EA (1) EA201990253A1 (es)
MX (1) MX2019000429A (es)
WO (1) WO2017008153A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019010566A1 (en) * 2017-07-10 2019-01-17 UNIVERSITé LAVAL ANTI-S100A8 / A9 TO INHIBIT THE IMMUNOSUPPRESSIVE ACTIVITY OF MDSC CELLS
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
AU2021313388A1 (en) 2020-07-23 2023-01-19 Erasmus University Medical Center Rotterdam (Erasmus Mc) S100 proteins as novel therapeutic targets in myeloproliferative neoplasms
CN114057860B (zh) * 2021-11-09 2023-10-20 中国科学技术大学 特定组氨酸甲基化修饰的s100a9蛋白免疫原、多克隆抗体及其制备方法
WO2025049915A1 (en) * 2023-08-31 2025-03-06 Exelixis, Inc. Ilt2 binding agents and uses thereof
WO2025085746A1 (en) * 2023-10-18 2025-04-24 Immunorx Pharma Inc. Humanized anti-s100a9 antibody

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE60327075D1 (de) * 2002-07-05 2009-05-20 Univ Laval Der entzündungsreaktionen
ATE510853T1 (de) * 2003-09-23 2011-06-15 Univ Muenchen Tech Tlr2-antagonistischer antikörper und dessen verwendung
US8841421B2 (en) * 2007-04-26 2014-09-23 Active Biotech, Ab S100A9 interaction screening method
US8420387B2 (en) * 2009-11-06 2013-04-16 Agrivida, Inc. Intein-modified enzymes, their production and industrial applications
WO2012155049A1 (en) * 2011-05-11 2012-11-15 Medimmune, Llc Treatment of lung inflammation

Also Published As

Publication number Publication date
US20210277101A1 (en) 2021-09-09
EA201990253A1 (ru) 2019-06-28
JP2019527212A (ja) 2019-09-26
JP6953033B2 (ja) 2021-10-27
KR20190032419A (ko) 2019-03-27
CA3030320A1 (en) 2017-01-19
CN109641951A (zh) 2019-04-16
BR112019000635A2 (pt) 2019-04-30
EP3481863A4 (en) 2020-03-11
EP3481863A1 (en) 2019-05-15
AU2016293391A1 (en) 2019-02-14
KR102234279B1 (ko) 2021-03-30
US11359010B2 (en) 2022-06-14
WO2017008153A1 (en) 2017-01-19
AU2016293391B2 (en) 2023-11-23

Similar Documents

Publication Publication Date Title
ZA202107931B (en) Anti-tau antibodies and methods of use
PH12017500861A1 (en) Anti-interleukin-33 antibodies and uses thereof
MX2024000300A (es) Anticuerpos antitau y metodos de uso.
MX2019001471A (es) Anticuerpos anti-siglec-7 para el tratamiento del cancer.
PH12016501894A1 (en) Anti-ox40 antibodies and methods of use
PH12017500877B1 (en) ANTI-CD79b ANTIBODIES AND METHODS OF USE
NZ731467A (en) Anti-tim3 antibodies and methods of use
MX2018010295A (es) Anticuerpos que tienen especificidad para atenuador de linfocitos b y t (btla) y usos de los mismos.
MY188940A (en) Anti-pd-l1 antibodies and diagnostic uses thereof
MX2019000429A (es) Anticuerpo dirigido contra s100a9 humanizado y usos del mismo.
WO2016062722A8 (en) Combination
MX2017004715A (es) Anticuerpos anti-ox40 humanizados y usos de los mismos.
HK1231513A1 (zh) 活化素抑制劑應答預測和用於治療的用途
MX2020011783A (es) Terapia de combinacion que involucra anticuerpos contra claudina 18.2 para tratamiento de cancer.
SG10201808940WA (en) Nox inhibitor and nfкb inhibitor containing methoxyflavone
PH12016500940A1 (en) HUMANIZED ANTI-Tau(pS422) ANTIBODIES AND METHODS OF USE
MY176855A (en) Anti-jagged1 antibodies and methods of use
EP3270966A4 (en) Combination of hdac inhibitor and anti-pd-1 antibody for treatment of cancer
EP3313433A4 (en) Combination of hdac inhibitor and anti-pd-l1 antibody for treatment of cancer
MX2015012428A (es) Tratamiento contra enfermedades mediadas th2 por inhibicion de bromodominios.
MX2018008732A (es) Inhibicion de la reaccion alergica usando un inhibidor de il-33.
PH12017501864A1 (en) Compositions and methods for treating autism
NZ754522A (en) Oxabicycloheptanes for modulation of immune response
MX2015009153A (es) Uso de agonistas del receptor nicotinico de acetilcolina alfa 7.
EA201891528A1 (ru) Композиции и способы обнаружения и лечения рака желудка