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MX2015012428A - Tratamiento contra enfermedades mediadas th2 por inhibicion de bromodominios. - Google Patents

Tratamiento contra enfermedades mediadas th2 por inhibicion de bromodominios.

Info

Publication number
MX2015012428A
MX2015012428A MX2015012428A MX2015012428A MX2015012428A MX 2015012428 A MX2015012428 A MX 2015012428A MX 2015012428 A MX2015012428 A MX 2015012428A MX 2015012428 A MX2015012428 A MX 2015012428A MX 2015012428 A MX2015012428 A MX 2015012428A
Authority
MX
Mexico
Prior art keywords
treating
brd9
brd7
bromodomain
inhibition
Prior art date
Application number
MX2015012428A
Other languages
English (en)
Inventor
Benjamin Fauber
Terry Crawford
Christopher G Nasveschuk
Hon-Ren Huang
Robert J Sims Iii
Brian K Albrecht
Steven Magnuson
Alexandre Cote
Jose M Lora
Andres Salmeron
Alexander M Taylor
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2015012428A publication Critical patent/MX2015012428A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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Abstract

Se proporcionan métodos para el tratamiento de enfermedades mediadas de citocina Th2 por medio de la función inhibitoria de bromodominios.
MX2015012428A 2013-03-15 2014-03-14 Tratamiento contra enfermedades mediadas th2 por inhibicion de bromodominios. MX2015012428A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361798644P 2013-03-15 2013-03-15
PCT/US2014/029252 WO2014144721A2 (en) 2013-03-15 2014-03-14 Treating th2-mediated diseases by inhibition of bromodomains

Publications (1)

Publication Number Publication Date
MX2015012428A true MX2015012428A (es) 2016-01-12

Family

ID=50942309

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012428A MX2015012428A (es) 2013-03-15 2014-03-14 Tratamiento contra enfermedades mediadas th2 por inhibicion de bromodominios.

Country Status (11)

Country Link
US (1) US20160024504A1 (es)
EP (1) EP2968263A2 (es)
JP (1) JP2016519672A (es)
KR (1) KR20150132198A (es)
CN (1) CN105050595A (es)
BR (1) BR112015023184A2 (es)
CA (1) CA2906100A1 (es)
HK (1) HK1211471A1 (es)
MX (1) MX2015012428A (es)
RU (1) RU2015144185A (es)
WO (1) WO2014144721A2 (es)

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CA2799420C (en) 2010-05-14 2018-10-02 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating neoplasia, inflammatory disease and other disorders
CA2799403C (en) 2010-05-14 2020-01-21 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating leukemia
MX379463B (es) 2013-11-08 2025-03-10 Dana Farber Cancer Inst Inc Terapia de combinación para el cáncer usando inhibidores de la proteína bromodominio y extra-terminal.
WO2015127351A1 (en) * 2014-02-24 2015-08-27 Celgene Corporation Methods of using an activator of cereblon for neural cell expansion and the treatment of central nervous system disorders
RU2722179C2 (ru) 2014-02-28 2020-05-28 Тэнша Терапеутикс, Инк. Лечение состояний, ассоциированных с гиперинсулинемией
JP6767969B2 (ja) 2014-09-05 2020-10-14 ジェネンテック， インコーポレイテッド がんの処置における使用のためのｐｃａｆおよびｇｃｎ５阻害剤としての式（ｉ）のフタラジン誘導体
JP6814730B2 (ja) 2014-09-05 2021-01-20 ジェネンテック， インコーポレイテッド 治療用化合物およびその使用
BR112017008714A2 (pt) 2014-10-27 2017-12-19 Tensha Therapeutics Inc inibidores de bromodomínio
WO2016112298A1 (en) * 2015-01-09 2016-07-14 Genentech, Inc. Pyridazinone derivatives and their use in the treatment of cancer
BR112018006689A2 (pt) * 2015-10-02 2018-10-09 Dana Farber Cancer Inst Inc terapia de combinação de inibidores de bromodomínio e bloqueio de ponto de controle
CN114617962A (zh) 2016-04-27 2022-06-14 艾伯维公司 使用抗-il-13抗体治疗il-13活性在其中有害的疾病的方法
EP3830112A4 (en) * 2018-07-30 2022-12-21 University of Southern California IMPROVING THE EFFICIENCY AND SAFETY OF ADOPTIVE CELLULAR THERAPIES
CN109125729A (zh) * 2018-09-06 2019-01-04 苏州吉玛基因股份有限公司 与非小细胞肺癌诊疗相关的基因BRD9及其siRNAs和应用
CN109180547A (zh) * 2018-10-16 2019-01-11 王莉 用于治疗2型糖尿病的维生素d药物的合成方法及应用
GB201905721D0 (en) 2019-04-24 2019-06-05 Univ Dundee Compounds
WO2022183056A1 (en) * 2021-02-26 2022-09-01 Salk Institute For Biological Studies Modulating regulatory t cell function in autoimmune disease and cancer

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US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
IL155991A0 (en) * 2000-12-01 2003-12-23 Max Planck Gesellschaft Rna interference mediating small rna molecules
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WO2013097052A1 (en) * 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors

Also Published As

Publication number Publication date
KR20150132198A (ko) 2015-11-25
HK1211471A1 (en) 2016-05-27
CA2906100A1 (en) 2014-09-18
EP2968263A2 (en) 2016-01-20
RU2015144185A (ru) 2017-04-26
CN105050595A (zh) 2015-11-11
US20160024504A1 (en) 2016-01-28
WO2014144721A2 (en) 2014-09-18
WO2014144721A3 (en) 2015-04-16
JP2016519672A (ja) 2016-07-07
BR112015023184A2 (pt) 2017-11-21

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