[go: up one dir, main page]

MX2018015656A - Compuestos heterociclicos como antibacterianos. - Google Patents

Compuestos heterociclicos como antibacterianos.

Info

Publication number
MX2018015656A
MX2018015656A MX2018015656A MX2018015656A MX2018015656A MX 2018015656 A MX2018015656 A MX 2018015656A MX 2018015656 A MX2018015656 A MX 2018015656A MX 2018015656 A MX2018015656 A MX 2018015656A MX 2018015656 A MX2018015656 A MX 2018015656A
Authority
MX
Mexico
Prior art keywords
antibacterials
heterocyclic compounds
compounds
tuberculosis
medicaments
Prior art date
Application number
MX2018015656A
Other languages
English (en)
Inventor
Jean- Marie Bernard Raboisson Pierre
Émile Georges Guillemont Jérôme
Tahri Abdellah
Original Assignee
Janssen Sciences Ireland Unlimited Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Unlimited Co filed Critical Janssen Sciences Ireland Unlimited Co
Publication of MX2018015656A publication Critical patent/MX2018015656A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invencion se refiere a los siguientes compuestos en los que los numeros enteros son tal como se definen en la descripcion, y en donde los compuestos pueden ser utiles como medicamentos, por ejemplo, para su uso en el tratamiento de la tuberculosis.
MX2018015656A 2016-06-16 2017-06-15 Compuestos heterociclicos como antibacterianos. MX2018015656A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16174719 2016-06-16
PCT/EP2017/064652 WO2017216281A1 (en) 2016-06-16 2017-06-15 Heterocyclic compounds as antibacterials

Publications (1)

Publication Number Publication Date
MX2018015656A true MX2018015656A (es) 2019-03-14

Family

ID=56132837

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018015656A MX2018015656A (es) 2016-06-16 2017-06-15 Compuestos heterociclicos como antibacterianos.

Country Status (12)

Country Link
US (1) US11179396B2 (es)
EP (1) EP3472158A1 (es)
JP (1) JP2019518046A (es)
KR (1) KR20190017948A (es)
CN (1) CN109476657A (es)
AU (1) AU2017286368B2 (es)
BR (1) BR112018076126A2 (es)
CA (1) CA3026010A1 (es)
EA (1) EA201990043A1 (es)
MA (1) MA45377A (es)
MX (1) MX2018015656A (es)
WO (1) WO2017216281A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT202200220T1 (it) 2015-07-02 2022-07-21 Janssen Sciences Ireland Unlimited Co Composti antibatterici
WO2017049321A1 (en) 2015-09-17 2017-03-23 Miller Marvin J Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection
JP2019518046A (ja) 2016-06-16 2019-06-27 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー 抗菌薬としての複素環式化合物
CN110831630A (zh) 2017-03-01 2020-02-21 爱尔兰詹森科学公司 组合疗法
CN111108105B (zh) 2017-09-22 2023-03-31 朱比兰特埃皮帕德有限公司 作为pad抑制剂的杂环化合物
PL3697785T3 (pl) 2017-10-18 2023-08-07 Jubilant Epipad LLC Związki imidazopirydynowe jako inhibitory pad
KR20200085836A (ko) 2017-11-06 2020-07-15 주빌런트 프로델 엘엘씨 Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체
DK3704120T3 (da) 2017-11-24 2024-05-21 Jubilant Episcribe Llc Heterocykliske forbindelser som prmt5-inhibitorer
EP3765453A1 (en) 2018-03-13 2021-01-20 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation
EP4028399B1 (en) 2019-09-13 2024-02-14 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
CN114746089A (zh) * 2019-09-26 2022-07-12 结核病药物开发全球联盟公司 噻唑甲酰胺化合物及其用于治疗分枝杆菌感染的用途
AU2020358643A1 (en) 2019-09-30 2022-05-26 Janssen Sciences Ireland Unlimited Company 4-quinolinone antibacterial compounds
AU2020360560A1 (en) 2019-09-30 2022-03-10 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
EP4308239A1 (en) 2021-03-16 2024-01-24 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
BR112023018655A2 (pt) 2021-03-17 2023-12-12 Janssen Sciences Ireland Unlimited Co Compostos antibacterianos
MX2023010941A (es) 2021-03-17 2023-11-28 Janssen Sciences Ireland Unlimited Co Compuestos antibacterianos.
WO2022214519A1 (en) 2021-04-07 2022-10-13 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
WO2022214520A1 (en) 2021-04-07 2022-10-13 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
US20250034171A1 (en) 2021-10-28 2025-01-30 Janssen Sciences Ireland Unlimited Company Imidazopyridine amides and related compounds for use in the treatment of bacterial infections
WO2024089170A1 (en) 2022-10-27 2024-05-02 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
WO2024223859A1 (en) 2023-04-26 2024-10-31 Janssen Pharmaceutica Nv Antibacterial compounds

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9509673A (pt) 1994-11-15 1997-09-30 Upjohn Co Compostos e uso dos mesmos
JPH11506430A (ja) * 1995-05-11 1999-06-08 ファルマシア・アンド・アップジョン・カンパニー スピロ環式および二環式ジアジニル−およびカルバジニル−オキサゾリジノン
BRPI0312927B8 (pt) 2002-07-25 2021-05-25 Janssen Pharmaceutica Nv "compostos, derivados de quinolina, composição, seu uso como inibidores micobacteriais, bem como processo para preparação dos referidos derivados".
AR042956A1 (es) 2003-01-31 2005-07-13 Vertex Pharma Inhibidores de girasa y usos de los mismos
MA27360A1 (fr) 2004-11-23 2005-06-01 Brahim Bennani Synthese et application des spiro-isoxazolines comme agents anti-tuberculeux
JP2010513495A (ja) 2006-12-20 2010-04-30 シェーリング コーポレイション 新規なｊｎｋ阻害剤
TW200901969A (en) 2007-06-06 2009-01-16 Smithkline Beecham Corp Chemical compounds
TWI498115B (zh) 2007-12-27 2015-09-01 Daiichi Sankyo Co Ltd 咪唑羰基化合物
CA2712613C (en) 2008-03-26 2017-02-28 Global Alliance For Tb Drug Development Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones
AU2009294850B2 (en) 2008-09-22 2015-07-02 Oregon Health & Science University Methods for detecting a Mycobacterium tuberculosis infection
MX2011006997A (es) 2008-12-30 2011-10-21 Sunesis Pharmaceuticals Inc Compuestos de heteroarilo utiles como inhibidores de cinasa de factor recombinante activado (raf).
BR112012010752B1 (pt) 2009-11-05 2021-07-20 University Of Notre Dame Du Lac Compostos imidazo[1,2-a]piridina
AU2011229423B2 (en) * 2010-03-18 2015-12-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Anti-infective compounds
US9029389B2 (en) 2011-04-21 2015-05-12 Institut Pasteur Korea Anti-inflammation compounds
US9199981B2 (en) 2011-09-01 2015-12-01 Novartis Ag Compounds and compositions as C-kit kinase inhibitors
CN103797011B (zh) 2011-09-01 2016-03-30 诺华股份有限公司 作为c-Kit激酶抑制剂的化合物和组合物
CA2865525C (en) 2012-03-02 2019-05-21 Genentech, Inc. Amido spirocyclic amide and sulfonamide derivatives
KR101918469B1 (ko) 2012-06-04 2018-11-15 한국화학연구원 바이사이클릭 니트로이미다졸 유도체 또는 이들의 광학이성질체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약제학적 조성물
KR102178590B1 (ko) * 2012-07-18 2020-11-13 유니버시티 오브 노트르 담 듀락 5,5-헤테로방향족 항-감염 화합물
EA201590339A1 (ru) * 2012-08-10 2015-06-30 Янссен Сайенсиз Айрлэнд Юси Новые антибактериальные соединения
KR101650716B1 (ko) 2012-11-22 2016-08-24 한국화학연구원 바이시클릭니트로이미다졸 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 결핵의 예방 또는 치료용 약학적 조성물
DK3027615T3 (da) 2013-08-02 2021-10-25 Pasteur Institut Korea Antiinfektionsforbindelser
KR101564425B1 (ko) 2013-11-26 2015-10-30 한국화학연구원 신규한 바이사이클릭 니트로이미다졸 카바메이트 화합물, 이를 제조하는 방법 및 이를 유효성분으로 함유하는 결핵 질환의 예방 또는 치료용 약제학적 조성물
CN105524058B (zh) * 2014-10-21 2018-03-27 广州艾格生物科技有限公司 吡唑并[1,5‑a]吡啶类化合物及其应用
WO2016073524A1 (en) 2014-11-03 2016-05-12 The Regents Of The University Of California Multi-drug therapies for tuberculosis treatment
SMT202200220T1 (it) 2015-07-02 2022-07-21 Janssen Sciences Ireland Unlimited Co Composti antibatterici
JP2019518046A (ja) 2016-06-16 2019-06-27 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー 抗菌薬としての複素環式化合物
CN109415349A (zh) 2016-06-16 2019-03-01 爱尔兰詹森科学公司 杂环化合物作为抗细菌剂
CN110831630A (zh) 2017-03-01 2020-02-21 爱尔兰詹森科学公司 组合疗法

Also Published As

Publication number Publication date
AU2017286368A1 (en) 2018-12-06
WO2017216281A1 (en) 2017-12-21
EP3472158A1 (en) 2019-04-24
CN109476657A (zh) 2019-03-15
US20190134046A1 (en) 2019-05-09
BR112018076126A2 (pt) 2019-03-26
MA45377A (fr) 2019-04-24
CA3026010A1 (en) 2017-12-21
AU2017286368B2 (en) 2021-02-25
KR20190017948A (ko) 2019-02-20
EA201990043A1 (ru) 2019-05-31
US11179396B2 (en) 2021-11-23
JP2019518046A (ja) 2019-06-27

Similar Documents

Publication Publication Date Title
MX2018015656A (es) Compuestos heterociclicos como antibacterianos.
ZA201708692B (en) Antibacterial compounds
MX2018015657A (es) Compuestos heterociclico como antibacterianos.
PH12019502646A1 (en) Pyrazole magl inhibitors
NZ736665A (en) Heterocyclic amides as kinase inhibitors
MY187540A (en) Compounds active towards bromodomains
SG10201811454WA (en) Materials and methods for controlling infections
MX2017011997A (es) Carbamatos de piperacina y metodos de preparacion y uso.
MX2016016143A (es) Compuestos de [1,2,4]triazol sustituido.
PH12019502002A1 (en) Combination theraphy
PH12014501991B1 (en) Phenicol antibacterials
AU2015299431B2 (en) Pyrrolidinone derivatives as metAP-2 inhibitors
PH12018501279A1 (en) Compositions comprising 15-hepe and methods of using the same
MX2021010886A (es) Uso de medicamentos para disminuir la evolucion de la enfermedad de parkinson.
MX2017007188A (es) Compuesto antimicotico.
PH12014501534A1 (en) Inhibitors of iap
PH12016501865A1 (en) Pyridine-2-amides useful as cb2 agonists
GEP20186893B (en) Pyrazines modulators of gpr6
MX382092B (es) Compuestos heterocíclicos para el tratamiento de enfermedades.
MX2016004078A (es) Formulacion de atazanavir y cobicistat para el tratamiento del virus de inmunodeficiencia humana (vih).
MX2015013755A (es) Formulacion farmaceutica para uso en el tratamiento y/o prevencion de restenosis.
MX2022003816A (es) Compuestos antibacterianos.
MX2022003814A (es) Compuestos antibacterianos de 4-quinolinona.
UA93017U (uk) Препарат "нановулін-врх"
HK1240079A1 (en) Method for treating hyperhidrosis