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MX2018015315A - Agentes antivirales contra la hepatitis b. - Google Patents

Agentes antivirales contra la hepatitis b.

Info

Publication number
MX2018015315A
MX2018015315A MX2018015315A MX2018015315A MX2018015315A MX 2018015315 A MX2018015315 A MX 2018015315A MX 2018015315 A MX2018015315 A MX 2018015315A MX 2018015315 A MX2018015315 A MX 2018015315A MX 2018015315 A MX2018015315 A MX 2018015315A
Authority
MX
Mexico
Prior art keywords
hepatitis
hbv
present
antiviral agents
compounds
Prior art date
Application number
MX2018015315A
Other languages
English (en)
Inventor
Peng Xiaowen
Cao Hui
Jin Meizhong
Li Wei
Qiu Yao-Ling
Gao Xuri
Kass Jorden
Sun Or Yat
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of MX2018015315A publication Critical patent/MX2018015315A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención describe compuestos de Fórmula (I), o sales aceptables farmacéuticamente de estos: que inhiben la(s) proteína(s) codificada(s) por el virus de la hepatitis B (VHB) o interfieren con la función del ciclo de vida del virus de la hepatitis B y son útiles además como agentes antivirales. La presente invención se relaciona además con las composiciones farmacéuticas que comprenden los compuestos antes mencionados para la administración a un sujeto que padece de infección por el VHB. La invención se refiere, además, a métodos para tratar una infección por VHB en un sujeto mediante la administración de una composición farmacéutica que comprende los compuestos de la presente invención.
MX2018015315A 2016-06-10 2017-06-08 Agentes antivirales contra la hepatitis b. MX2018015315A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662348419P 2016-06-10 2016-06-10
US201762443245P 2017-01-06 2017-01-06
PCT/US2017/036553 WO2017214395A1 (en) 2016-06-10 2017-06-08 Hepatitis b antiviral agents

Publications (1)

Publication Number Publication Date
MX2018015315A true MX2018015315A (es) 2019-04-25

Family

ID=60573663

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018015315A MX2018015315A (es) 2016-06-10 2017-06-08 Agentes antivirales contra la hepatitis b.

Country Status (15)

Country Link
US (3) US10189846B2 (es)
EP (1) EP3468561A4 (es)
JP (1) JP2019521972A (es)
KR (1) KR20190027814A (es)
CN (1) CN109843296A (es)
AU (1) AU2017277664A1 (es)
BR (1) BR112018075465A2 (es)
CA (1) CA3028228A1 (es)
CL (1) CL2018003492A1 (es)
CO (1) CO2019000069A2 (es)
IL (1) IL263535A (es)
MX (1) MX2018015315A (es)
PH (1) PH12018550201A1 (es)
SG (1) SG11201810834WA (es)
WO (1) WO2017214395A1 (es)

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