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MX2018013728A - Metodo de produccion de celastrol y derivados de triterpeno pentaciclicos. - Google Patents

Metodo de produccion de celastrol y derivados de triterpeno pentaciclicos.

Info

Publication number
MX2018013728A
MX2018013728A MX2018013728A MX2018013728A MX2018013728A MX 2018013728 A MX2018013728 A MX 2018013728A MX 2018013728 A MX2018013728 A MX 2018013728A MX 2018013728 A MX2018013728 A MX 2018013728A MX 2018013728 A MX2018013728 A MX 2018013728A
Authority
MX
Mexico
Prior art keywords
producing
celastrol
pentacyclic triterpene
triterpene derivatives
extract
Prior art date
Application number
MX2018013728A
Other languages
English (en)
Other versions
MX386585B (es
Inventor
Nguyen Thien
COUSY Adrien
Steward Nicolas
Original Assignee
Fabre Pierre Dermo Cosmetique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabre Pierre Dermo Cosmetique filed Critical Fabre Pierre Dermo Cosmetique
Publication of MX2018013728A publication Critical patent/MX2018013728A/es
Publication of MX386585B publication Critical patent/MX386585B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H4/00—Plant reproduction by tissue culture techniques ; Tissue culture techniques therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/11—Preparation or pretreatment of starting material involving culturing conditions, e.g. cultivation in the dark or under defined water stress

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Environmental Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un método para producir un extracto crudo enriquecido en triterpenos pentacíclicos, incluyendo celastrol, a partir de células de una planta de la familia Celastraceae; a un extracto crudo enriquecido que puede obtenerse usando tal método; a aplicaciones terapéuticas de tal extracto; y a composiciones farmacéuticas y dermocosméticas que contienen tal extracto.
MX2018013728A 2016-05-12 2017-05-12 Método de producción de celastrol y derivados de triterpeno pentacíclicos. MX386585B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1654240A FR3051116B1 (fr) 2016-05-12 2016-05-12 Procede de production du celastrol et de derives triterpeniques pentacycliques
PCT/EP2017/061504 WO2017194757A1 (fr) 2016-05-12 2017-05-12 Procede de production du celastrol et de derives triterpeniques pentacycliques

Publications (2)

Publication Number Publication Date
MX2018013728A true MX2018013728A (es) 2019-08-01
MX386585B MX386585B (es) 2025-03-19

Family

ID=56404155

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018013728A MX386585B (es) 2016-05-12 2017-05-12 Método de producción de celastrol y derivados de triterpeno pentacíclicos.

Country Status (11)

Country Link
US (1) US20190134128A1 (es)
EP (1) EP3454875B1 (es)
KR (1) KR102513830B1 (es)
BR (1) BR112018073117B1 (es)
ES (1) ES2831835T3 (es)
FR (1) FR3051116B1 (es)
MX (1) MX386585B (es)
PT (1) PT3454875T (es)
RU (1) RU2743715C1 (es)
SG (1) SG11201809948XA (es)
WO (1) WO2017194757A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3047665B1 (fr) * 2016-02-17 2020-12-11 Pf Medicament Celastrol et ses derives dans le traitement des tumeurs et pathologies pre-cancereuses cutanees
LU101117B1 (en) * 2019-02-07 2020-08-07 Luxembourg Institute Of Science And Tech (List) METHOD FOR PRODUCING A COMPOSITION COMPRISING A 3-O-p-COUMAROYL ESTER OF TORMENTIC ACID FROM A PLANT CELL CULTURE, APPLICATIONS THEREOF AS ANTIPARASITIC AGENT FOR THE TREATMENT OF TRYPANOSOMIASIS
FR3095754B1 (fr) * 2019-05-10 2021-11-19 Fabre Pierre Dermo Cosmetique Triterpènes pentacycliques dans le traitement du vitiligo
FR3120790B1 (fr) 2021-03-10 2024-03-15 Fabre Pierre Dermo Cosmetique Association d’un extrait de myrte et d’un extrait de Tripterygium wilfordii pour lutter contre l’inflammation induite par C. acnes
US20250333774A1 (en) 2021-10-19 2025-10-30 Glaxosmithkline Biologicals Sa Saponin Production
FR3132632B1 (fr) * 2022-02-17 2025-05-23 Fabre Pierre Dermo Cosmetique Composition comprenant un extrait de myrte et un extrait de Tripterygium wilfordii pour lutter contre l’acné des zones non lésionnelles de la peau acnéique
CA3253348A1 (en) 2022-06-15 2023-12-21 Glaxosmithkline Biologicals Sa ENZYMATIC MODIFICATION OF SAPONINS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101086642B1 (ko) * 2009-02-27 2011-11-24 강원대학교산학협력단 셀라스트롤을 유효성분으로 포함하는 알러지 질환 예방 및 치료용 조성물
FR2952072B1 (fr) * 2009-11-05 2013-09-27 Pf Medicament Procede de production de triptolide
AU2012223307A1 (en) * 2011-03-01 2013-08-29 Phytomedics Corporation Inc. Methods of processing extracts of a T. wilfordii Hook F. plant
CN103159822B (zh) * 2013-03-04 2016-05-18 华侨大学 雷公藤甲素及其衍生物组合物的制备方法

Also Published As

Publication number Publication date
FR3051116B1 (fr) 2019-06-07
FR3051116A1 (fr) 2017-11-17
EP3454875B1 (fr) 2020-09-23
ES2831835T3 (es) 2021-06-09
KR20190006523A (ko) 2019-01-18
SG11201809948XA (en) 2018-12-28
RU2743715C1 (ru) 2021-02-24
BR112018073117B1 (pt) 2022-10-25
PT3454875T (pt) 2020-12-11
EP3454875A1 (fr) 2019-03-20
CA3023192A1 (fr) 2017-11-16
BR112018073117A2 (pt) 2019-03-06
KR102513830B1 (ko) 2023-03-23
MX386585B (es) 2025-03-19
US20190134128A1 (en) 2019-05-09
WO2017194757A1 (fr) 2017-11-16

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