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MX2018012539A - Composiciones y métodos de células t receptoras de aloantígeno quimérico. - Google Patents

Composiciones y métodos de células t receptoras de aloantígeno quimérico.

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Publication number
MX2018012539A
MX2018012539A MX2018012539A MX2018012539A MX2018012539A MX 2018012539 A MX2018012539 A MX 2018012539A MX 2018012539 A MX2018012539 A MX 2018012539A MX 2018012539 A MX2018012539 A MX 2018012539A MX 2018012539 A MX2018012539 A MX 2018012539A
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MX
Mexico
Prior art keywords
callar
compositions
cells
methods
chemeric
Prior art date
Application number
MX2018012539A
Other languages
English (en)
Inventor
C Milone Michael
ARRUDA Valder
Richman Sarah
Samelson-Jones Benjamin
Original Assignee
Univ Pennsylvania
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Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of MX2018012539A publication Critical patent/MX2018012539A/es

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K2239/21—Transmembrane domain
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Abstract

La invención incluye composiciones que comprenden al menos un receptor de aloantígeno quimérico (CALLAR) específico para un aloanticuerpo, vectores que comprenden el mismo, composiciones que comprenden vectores de CALLAR empacados en partículas virales, y células T recombinantes que comprenden el CALLAR; la invención también incluye métodos para preparar una célula T genéticamente modificada que expresa un CALLAR, en donde el CALLAR expresado comprende un factor VIII o fragmento del mismo en el dominio extracelular.
MX2018012539A 2016-04-15 2017-04-14 Composiciones y métodos de células t receptoras de aloantígeno quimérico. MX2018012539A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662322937P 2016-04-15 2016-04-15
PCT/US2017/027754 WO2017181101A1 (en) 2016-04-15 2017-04-14 Compositions and methods of chimeric alloantigen receptor t cells

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MX2018012539A true MX2018012539A (es) 2019-07-08

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MX2018012539A MX2018012539A (es) 2016-04-15 2017-04-14 Composiciones y métodos de células t receptoras de aloantígeno quimérico.

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US (3) US20190153064A1 (es)
EP (1) EP3443076A4 (es)
JP (3) JP2019513394A (es)
KR (1) KR20190003550A (es)
CN (1) CN109328230A (es)
AU (2) AU2017248817A1 (es)
CA (1) CA3020599A1 (es)
MX (1) MX2018012539A (es)
RU (1) RU2018140056A (es)
WO (1) WO2017181101A1 (es)

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US20190153064A1 (en) 2019-05-23
AU2023222993A1 (en) 2023-11-02
RU2018140056A3 (es) 2020-10-16
US20220220188A1 (en) 2022-07-14
KR20190003550A (ko) 2019-01-09
JP2019513394A (ja) 2019-05-30
EP3443076A4 (en) 2020-04-15
WO2017181101A1 (en) 2017-10-19
AU2017248817A1 (en) 2018-11-15
US20260028386A1 (en) 2026-01-29
EP3443076A1 (en) 2019-02-20
JP2024138334A (ja) 2024-10-08
RU2018140056A (ru) 2020-05-15
CN109328230A (zh) 2019-02-12
JP2022133308A (ja) 2022-09-13
CA3020599A1 (en) 2017-10-19

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