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MX2018012349A - Metodo para la cuantificacion de la pureza de muestras de particulas sub-visibles. - Google Patents

Metodo para la cuantificacion de la pureza de muestras de particulas sub-visibles.

Info

Publication number
MX2018012349A
MX2018012349A MX2018012349A MX2018012349A MX2018012349A MX 2018012349 A MX2018012349 A MX 2018012349A MX 2018012349 A MX2018012349 A MX 2018012349A MX 2018012349 A MX2018012349 A MX 2018012349A MX 2018012349 A MX2018012349 A MX 2018012349A
Authority
MX
Mexico
Prior art keywords
primary particles
objects
detected
purity
sub
Prior art date
Application number
MX2018012349A
Other languages
English (en)
Other versions
MX380840B (es
Inventor
Kylberg Gustaf
Maria SINTORN Ida-
Ryner Martin
Nilsson Josefina
Original Assignee
Intelligent Virus Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intelligent Virus Imaging Inc filed Critical Intelligent Virus Imaging Inc
Publication of MX2018012349A publication Critical patent/MX2018012349A/es
Publication of MX380840B publication Critical patent/MX380840B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B21/00—Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant
    • G01B21/28—Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant for measuring areas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B15/00—Measuring arrangements characterised by the use of electromagnetic waves or particle radiation, e.g. by the use of microwaves, X-rays, gamma rays or electrons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/02—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material
    • G01N23/04—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/40—Extraction of image or video features
    • G06V10/44—Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/601—Detection means characterised by use of a special device being a microscope, e.g. atomic force microscopy [AFM]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0038—Investigating nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/103—Particle shape
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00—Investigating materials by wave or particle radiation
    • G01N2223/40—Imaging
    • G01N2223/401—Imaging image processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00—Investigating materials by wave or particle radiation
    • G01N2223/40—Imaging
    • G01N2223/405—Imaging mapping of a material property

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Theoretical Computer Science (AREA)
  • Multimedia (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Signal Processing (AREA)
  • Electromagnetism (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Image Analysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

El método es para la cuantificación de la pureza de muestras de partículas sub-visibles. Una muestra que será analizada es colocada en un microscopio electrónico con el fin de obtener una imagen de microscopia electrónica (100) de la muestra. La muestra contiene objetos (114). Los objetos (114) que tengan tamaños diferentes al intervalo de tamaño de las partículas primarias (120) y tamaños que están dentro del intervalo de tamaño de las partículas primarias (120) son mejorados. Los objetos (114) son detectados como siendo partículas primarias (120) o restos (106). Las partículas primarias detectadas (120) son excluidas de los objetos (114) de una manera tal que los objetos (114) contienen restos (106) pero no partículas primarias (120). Es medida una primera área total (T1) de los restos detectados (106). Es medida una segunda área total (T2) de las partículas primarias detectadas (120).
MX2018012349A 2016-09-30 2017-09-11 Método para la cuantificación de la pureza de muestras de partículas sub-visibles. MX380840B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662402003P 2016-09-30 2016-09-30
PCT/US2017/050962 WO2018063785A1 (en) 2016-09-30 2017-09-11 Method for quantification of purity of sub-visible particle samples

Publications (2)

Publication Number Publication Date
MX2018012349A true MX2018012349A (es) 2018-12-17
MX380840B MX380840B (es) 2025-03-12

Family

ID=61762953

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018012349A MX380840B (es) 2016-09-30 2017-09-11 Método para la cuantificación de la pureza de muestras de partículas sub-visibles.

Country Status (24)

Country Link
US (2) US10451566B2 (es)
EP (1) EP3349872B1 (es)
JP (1) JP6790091B2 (es)
KR (1) KR102176815B1 (es)
CN (1) CN109715259B (es)
AU (1) AU2017335569B2 (es)
BR (1) BR112018012570A2 (es)
CA (1) CA2997325C (es)
CL (1) CL2018002522A1 (es)
DK (1) DK3349872T3 (es)
EA (1) EA036586B1 (es)
ES (1) ES2774533T3 (es)
HU (1) HUE048000T2 (es)
IL (1) IL259279B (es)
MA (1) MA42888B1 (es)
MX (1) MX380840B (es)
MY (1) MY193420A (es)
NZ (1) NZ741498A (es)
PL (1) PL3349872T3 (es)
PT (1) PT3349872T (es)
SA (1) SA519401436B1 (es)
SG (1) SG11201805521XA (es)
UA (1) UA125437C2 (es)
WO (1) WO2018063785A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018063785A1 (en) * 2016-09-30 2018-04-05 Intelligent Virus Imaging Inc. Method for quantification of purity of sub-visible particle samples
KR102192033B1 (ko) * 2019-03-05 2020-12-16 서울대학교산학협력단 전자현미경 이미지 분석 방법
CN112697658B (zh) * 2019-10-23 2024-09-10 中国石油化工股份有限公司 存储器、电子显微镜颗粒几何性质测定方法、设备和装置
CN116563249A (zh) * 2023-05-11 2023-08-08 中国食品药品检定研究院 一种眼内注射剂的亚可见颗粒质控方法、系统及设备
CN116817804B (zh) * 2023-08-24 2023-11-03 江苏集创原子团簇科技研究院有限公司 一种多层石墨烯中离子注入深度精确标定方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3931927B2 (ja) * 1996-12-13 2007-06-20 株式会社ブリヂストン シリカ微小粒子又はカーボンブラック微小粒子形態の自動計測方法
US5917927A (en) * 1997-03-21 1999-06-29 Satake Corporation Grain inspection and analysis apparatus and method
WO2003025858A2 (en) * 2001-09-17 2003-03-27 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Method for identifying and quantifying characteristics of seeds and other small objects
WO2003095986A1 (en) * 2002-05-14 2003-11-20 Amersham Biosciences Niagara, Inc. System and methods for rapid and automated screening of cells
JP4761346B2 (ja) * 2005-03-28 2011-08-31 国立大学法人名古屋大学 ２層カーボンナノチューブ含有組成物
BRPI0609760C1 (pt) * 2005-04-15 2021-07-27 Intelligent Virus Imaging Inc "método de análise de partículas de vírus"
US8805039B2 (en) * 2005-10-12 2014-08-12 Intelligent Virus Imaging Inc Identification and classification of virus particles in textured electron micrographs
CN101681427B (zh) * 2007-05-30 2012-12-05 智能病毒成像公司 对图像中的病毒粒子进行计数和分割的方法
US8712141B2 (en) * 2007-05-30 2014-04-29 Intelligent Virus Imagaing Inc. Method for counting and segmenting viral particles in an image
SE532499C2 (sv) * 2008-01-18 2010-02-09 Hemocue Ab Metod och apparat för analys av partiklar i ett vätskeformigt prov
JP2011095182A (ja) * 2009-10-30 2011-05-12 Sysmex Corp 細胞分析装置及び細胞分析方法
EP2335825A1 (en) * 2009-12-21 2011-06-22 F. Hoffmann-La Roche AG Unit and device for the preparation of cells and/or particles in a liquid and method for microscopic analysis
CN111610138B (zh) * 2011-04-15 2023-06-09 罗氏血液诊断股份有限公司 测量细胞体积和成份
WO2018063785A1 (en) * 2016-09-30 2018-04-05 Intelligent Virus Imaging Inc. Method for quantification of purity of sub-visible particle samples

Also Published As

Publication number Publication date
IL259279A (en) 2018-07-31
US20190376910A1 (en) 2019-12-12
CN109715259A (zh) 2019-05-03
CA2997325A1 (en) 2018-03-30
US20190011378A1 (en) 2019-01-10
BR112018012570A2 (pt) 2018-12-04
NZ741498A (en) 2020-03-27
PT3349872T (pt) 2020-03-13
PL3349872T3 (pl) 2020-06-15
EA201890740A1 (ru) 2019-08-30
ES2774533T3 (es) 2020-07-21
MA42888B1 (fr) 2020-03-31
EA036586B1 (ru) 2020-11-26
CN109715259B (zh) 2021-02-26
HUE048000T2 (hu) 2020-05-28
DK3349872T3 (da) 2020-03-16
CA2997325C (en) 2023-03-28
IL259279B (en) 2021-10-31
US10451566B2 (en) 2019-10-22
EP3349872A1 (en) 2018-07-25
US11002689B2 (en) 2021-05-11
KR102176815B1 (ko) 2020-11-10
MY193420A (en) 2022-10-12
SA519401436B1 (ar) 2022-01-10
AU2017335569A1 (en) 2018-05-10
AU2017335569B2 (en) 2019-11-21
SG11201805521XA (en) 2018-07-30
JP2019532253A (ja) 2019-11-07
UA125437C2 (uk) 2022-03-09
JP6790091B2 (ja) 2020-11-25
MX380840B (es) 2025-03-12
MA42888A1 (fr) 2018-11-30
WO2018063785A1 (en) 2018-04-05
KR20190039464A (ko) 2019-04-12
EP3349872A4 (en) 2019-06-26
CL2018002522A1 (es) 2018-11-30
EP3349872B1 (en) 2019-12-11

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