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MX2018011792A - Compuestos de pirrolotriazina como inhibidores de tyro3, axl y mer (tam). - Google Patents

Compuestos de pirrolotriazina como inhibidores de tyro3, axl y mer (tam).

Info

Publication number
MX2018011792A
MX2018011792A MX2018011792A MX2018011792A MX2018011792A MX 2018011792 A MX2018011792 A MX 2018011792A MX 2018011792 A MX2018011792 A MX 2018011792A MX 2018011792 A MX2018011792 A MX 2018011792A MX 2018011792 A MX2018011792 A MX 2018011792A
Authority
MX
Mexico
Prior art keywords
pyrrolotriazine compounds
inhibitors
tam inhibitors
compounds
tam
Prior art date
Application number
MX2018011792A
Other languages
English (en)
Inventor
M Burns David
Zhuo Jincong
Li Yun-Long
Mei Song
Glenn Joseph
Feng Hao
Huang Taisheng
Wang Xiaozhao
Barbosa Joseph
He Chunhong
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MX2018011792A publication Critical patent/MX2018011792A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente solicitud hace referencia a compuestos de Fórmula I: (ver Fórmula) o sales farmacéuticamente aceptable de estos, que son inhibidores de cinasas TAM que resultan útiles para el tratamiento de trastornos tales como cáncer.
MX2018011792A 2016-03-28 2017-03-27 Compuestos de pirrolotriazina como inhibidores de tyro3, axl y mer (tam). MX2018011792A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662314066P 2016-03-28 2016-03-28
US201662362934P 2016-07-15 2016-07-15
US201662438750P 2016-12-23 2016-12-23
PCT/US2017/024270 WO2017172596A1 (en) 2016-03-28 2017-03-27 Pyrrolotriazine compounds as tam inhibitors

Publications (1)

Publication Number Publication Date
MX2018011792A true MX2018011792A (es) 2019-07-04

Family

ID=58489114

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018011792A MX2018011792A (es) 2016-03-28 2017-03-27 Compuestos de pirrolotriazina como inhibidores de tyro3, axl y mer (tam).

Country Status (31)

Country Link
US (5) US9981975B2 (es)
EP (2) EP4321513A3 (es)
JP (4) JP7034084B2 (es)
KR (3) KR102744951B1 (es)
CN (3) CN114456175B (es)
AU (3) AU2017241524B2 (es)
CL (1) CL2018002759A1 (es)
CO (1) CO2018011550A2 (es)
CR (1) CR20180516A (es)
DK (1) DK3436461T3 (es)
EC (3) ECSP18081153A (es)
ES (1) ES2967866T3 (es)
FI (1) FI3436461T3 (es)
HR (1) HRP20231614T1 (es)
HU (1) HUE064656T2 (es)
IL (2) IL261957B (es)
LT (1) LT3436461T (es)
MD (1) MD3436461T2 (es)
MX (1) MX2018011792A (es)
MY (1) MY202022A (es)
PE (1) PE20190175A1 (es)
PH (1) PH12018502102A1 (es)
PL (1) PL3436461T3 (es)
PT (1) PT3436461T (es)
RS (1) RS65129B1 (es)
SG (2) SG11201808582RA (es)
SI (1) SI3436461T1 (es)
SM (1) SMT202300480T1 (es)
TW (3) TWI753892B (es)
UA (1) UA123785C2 (es)
WO (1) WO2017172596A1 (es)

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EP3436461A1 (en) 2019-02-06
SMT202300480T1 (it) 2024-01-10
KR20190013721A (ko) 2019-02-11
IL293496B1 (en) 2023-01-01
CR20180516A (es) 2019-03-05
CL2018002759A1 (es) 2019-02-15
KR102483020B1 (ko) 2023-01-04
ECSP24026455A (es) 2024-07-31
CO2018011550A2 (es) 2018-12-14
KR20230008241A (ko) 2023-01-13
JP2022084663A (ja) 2022-06-07
TWI876724B (zh) 2025-03-11
AU2024201172C1 (en) 2025-09-25
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US10442810B2 (en) 2019-10-15
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MD3436461T2 (ro) 2024-05-31
TW202436299A (zh) 2024-09-16
EP4321513A3 (en) 2024-05-08
PT3436461T (pt) 2024-01-23
PH12018502102A1 (en) 2019-07-29
AU2021245220A1 (en) 2021-11-04
US20170275290A1 (en) 2017-09-28
ES2967866T3 (es) 2024-05-06
HUE064656T2 (hu) 2024-04-28
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US11591338B2 (en) 2023-02-28
IL293496B2 (en) 2023-05-01
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US20180327412A1 (en) 2018-11-15
CN114456176B (zh) 2024-08-30
CN114456175A (zh) 2022-05-10
EP4321513A2 (en) 2024-02-14
JP7271750B2 (ja) 2023-05-11
JP2023106404A (ja) 2023-08-01
MY202022A (en) 2024-03-29
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TW202241903A (zh) 2022-11-01
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CN109348715B (zh) 2021-12-31
PE20190175A1 (es) 2019-02-01

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