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MX2018011053A - Acido hialuronico modificado, metodo para preparar el mismo y usos del mismo. - Google Patents

Acido hialuronico modificado, metodo para preparar el mismo y usos del mismo.

Info

Publication number
MX2018011053A
MX2018011053A MX2018011053A MX2018011053A MX2018011053A MX 2018011053 A MX2018011053 A MX 2018011053A MX 2018011053 A MX2018011053 A MX 2018011053A MX 2018011053 A MX2018011053 A MX 2018011053A MX 2018011053 A MX2018011053 A MX 2018011053A
Authority
MX
Mexico
Prior art keywords
hyaluronic acid
making same
modified
hydrogel
modified hyaluronic
Prior art date
Application number
MX2018011053A
Other languages
English (en)
Inventor
Linko Alexander
Villain Franck
Krause Andreas
Original Assignee
Merz Pharma Gmbh & Co Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma Gmbh & Co Kgaa filed Critical Merz Pharma Gmbh & Co Kgaa
Publication of MX2018011053A publication Critical patent/MX2018011053A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Birds (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere en general a un ácido hialurónico (HA) modificado y a un método para prepararlo, más específicamente a un derivado de HA modificado con (poli)glicerol preparado injertando glicidol en HA. La presente invención también se refiere al uso del derivado de HA para preparar una composición de relleno dérmico, un hidrogel que comprende HA reticulado y el derivado de HA modificado con poli (glicerol), y un método para preparar dicho hidrogel. Además, la presente invención se refiere al uso del hidrogel como un producto cosmético y/o estético, en particular como un relleno dérmico para relleno, reemplazo y/o aumento del tejido.
MX2018011053A 2016-03-24 2017-03-21 Acido hialuronico modificado, metodo para preparar el mismo y usos del mismo. MX2018011053A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16000715 2016-03-24
PCT/EP2017/056701 WO2017162676A1 (en) 2016-03-24 2017-03-21 Modified hyaluronic acid, method for making same and uses thereof

Publications (1)

Publication Number Publication Date
MX2018011053A true MX2018011053A (es) 2019-03-28

Family

ID=55642206

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018011053A MX2018011053A (es) 2016-03-24 2017-03-21 Acido hialuronico modificado, metodo para preparar el mismo y usos del mismo.

Country Status (16)

Country Link
US (1) US10640578B2 (es)
EP (1) EP3433284A1 (es)
JP (1) JP6946323B2 (es)
KR (1) KR102316644B1 (es)
CN (1) CN108779185B (es)
AR (1) AR107967A1 (es)
AU (1) AU2017237457B2 (es)
BR (1) BR112018068559B8 (es)
CA (1) CA3016272A1 (es)
IL (1) IL261574B2 (es)
MX (1) MX2018011053A (es)
RU (1) RU2733444C2 (es)
SG (1) SG11201807185UA (es)
TW (1) TWI727014B (es)
WO (1) WO2017162676A1 (es)
ZA (1) ZA201805424B (es)

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EP3765103A1 (en) 2018-03-12 2021-01-20 Merz Pharma GmbH & Co. KGaA Porous biomaterials for tissue regeneration
JP2022512363A (ja) * 2018-12-19 2022-02-03 メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー アルデヒド変性ヒアルロン酸、それを調製するための方法およびその用途
IL284082B2 (en) 2018-12-19 2025-07-01 Evolved By Nature Inc Silk-hyaluronic acid tissue fillers and methods for their preparation and use
RS67193B1 (sr) * 2018-12-20 2025-10-31 Lg Chemical Ltd Filer sa odličnim svojstvima filera koji obuhvata hidrogel hijaluronske kiseline
JP7784138B2 (ja) * 2019-10-01 2025-12-11 バイオポリメリ エス．アール．エル． 超分岐ポリグリセロールポリグリシジルエーテルおよび多糖用の架橋物質としてのその使用
FR3111903B1 (fr) 2020-06-24 2022-12-02 Lab Vivacy Procede d’incorporation de composes organiques en solution au sein d’un hydrogel
FR3113522B1 (fr) 2020-08-20 2025-04-18 Lab Vivacy procédé d’évaluation des caractéristiques rhéologiques d’un gel
AU2022205343B2 (en) * 2021-01-07 2024-11-14 Lg Chem, Ltd. Crosslinked hyaluronic acid hydrogel crosslinked using crosslinker and polyol, and filler comprising same
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US20230255863A1 (en) * 2021-07-29 2023-08-17 Innomed Technologies, Inc. Formulations containing erythritol and combination skin therapies
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US20250075009A1 (en) * 2022-01-14 2025-03-06 Jenkem Technology Co., Ltd. (Tianjin) Hyaluronic acid derivative or salt thereof, and preparation method therefor and application thereof
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FR3135399B1 (fr) 2022-03-30 2025-03-28 Lab Vivacy émulsion comprenant un hydrogel et de la graisse ou un dérivé de graisse
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Also Published As

Publication number Publication date
IL261574B2 (en) 2024-03-01
EP3433284A1 (en) 2019-01-30
BR112018068559A2 (pt) 2019-04-16
IL261574B1 (en) 2023-11-01
IL261574A (en) 2018-10-31
TWI727014B (zh) 2021-05-11
CN108779185A (zh) 2018-11-09
RU2733444C2 (ru) 2020-10-01
JP2019509385A (ja) 2019-04-04
CA3016272A1 (en) 2017-09-28
US10640578B2 (en) 2020-05-05
JP6946323B2 (ja) 2021-10-06
BR112018068559B8 (pt) 2022-11-01
US20190100605A1 (en) 2019-04-04
ZA201805424B (en) 2019-04-24
KR20180127983A (ko) 2018-11-30
RU2018129659A3 (es) 2020-05-27
AU2017237457A1 (en) 2018-09-06
RU2018129659A (ru) 2020-04-24
TW201805008A (zh) 2018-02-16
AU2017237457B2 (en) 2021-04-08
KR102316644B1 (ko) 2021-10-26
SG11201807185UA (en) 2018-09-27
CN108779185B (zh) 2021-09-17
AR107967A1 (es) 2018-07-04
WO2017162676A1 (en) 2017-09-28
BR112018068559B1 (pt) 2022-09-20

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