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MX2018008882A - Composicion y metodo para el diagnostico y tratamiento de trastornos relacionados con hierro. - Google Patents

Composicion y metodo para el diagnostico y tratamiento de trastornos relacionados con hierro.

Info

Publication number
MX2018008882A
MX2018008882A MX2018008882A MX2018008882A MX2018008882A MX 2018008882 A MX2018008882 A MX 2018008882A MX 2018008882 A MX2018008882 A MX 2018008882A MX 2018008882 A MX2018008882 A MX 2018008882A MX 2018008882 A MX2018008882 A MX 2018008882A
Authority
MX
Mexico
Prior art keywords
iron
related disorders
diagnosis
treatment
composition
Prior art date
Application number
MX2018008882A
Other languages
English (en)
Inventor
Bernhard Mueller
Andreas Popp
Jennifer M Perez
Original Assignee
Abbvie Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Deutschland filed Critical Abbvie Deutschland
Publication of MX2018008882A publication Critical patent/MX2018008882A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un anticuerpo monoclonal humanizado aislado anti-molécula de orientación repulsiva c (RGMc) que comprende una región determinante de complementariedad (CDR)1 que consiste en la secuencia de aminoácidos de SEQ ID NO: 17, una CDR2 que consiste en la secuencia de aminoácidos de SEQ ID NO: 18, y una CDR3 que consiste en la secuencia de aminoácidos de SEQ ID NO: 19, y una región variable de la cadena ligera que comprende una CDR1 que consiste en la secuencia de aminoácidos de SEQ ID NO: 20, una CDR2 que consiste en la secuencia de aminoácidos de SEQ ID NO: 21, y una CDR3 que consiste en la secuencia de aminoácidos de SEQ ID NO: 22.
MX2018008882A 2011-12-14 2014-06-13 Composicion y metodo para el diagnostico y tratamiento de trastornos relacionados con hierro. MX2018008882A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161570715P 2011-12-14 2011-12-14

Publications (1)

Publication Number Publication Date
MX2018008882A true MX2018008882A (es) 2021-06-15

Family

ID=47436267

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014007177A MX357708B (es) 2011-12-14 2012-12-13 Composicion y metodo para el diagnostico y tratamiento de trastornos relacionados con hierro.
MX2018008882A MX2018008882A (es) 2011-12-14 2014-06-13 Composicion y metodo para el diagnostico y tratamiento de trastornos relacionados con hierro.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2014007177A MX357708B (es) 2011-12-14 2012-12-13 Composicion y metodo para el diagnostico y tratamiento de trastornos relacionados con hierro.

Country Status (8)

Country Link
US (5) US10118958B2 (es)
EP (2) EP2791173B1 (es)
JP (6) JP6342812B2 (es)
CN (2) CN107459576A (es)
AU (5) AU2012352168C1 (es)
CA (2) CA3204283A1 (es)
MX (2) MX357708B (es)
WO (1) WO2013090635A2 (es)

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JP2023528223A (ja) 2020-05-13 2023-07-04 ディスク・メディシン・インコーポレイテッド 骨髄線維症を処置するための抗ヘモジュベリン（ｈｊｖ）抗体
US20230183339A1 (en) * 2020-05-13 2023-06-15 Disc Medicine, Inc. Anti-hemojuvelin (hjv) antibodies for treating anemia of chronic disease
WO2022098812A1 (en) 2020-11-04 2022-05-12 Keros Therapeutics, Inc. Methods of treating iron overload
AU2022394462A1 (en) * 2021-11-17 2024-05-02 AbbVie Deutschland GmbH & Co. KG Methods for treating anemia of kidney disease
WO2025182763A1 (ja) * 2024-02-29 2025-09-04 富士レビオ株式会社 検出方法、検出装置、並びに、これらに用いる処理液及びキット

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