MX2018007219A - Metodos para preparacion de compuestos heterociclicos de 1,3-benzodioxol. - Google Patents
Metodos para preparacion de compuestos heterociclicos de 1,3-benzodioxol.Info
- Publication number
- MX2018007219A MX2018007219A MX2018007219A MX2018007219A MX2018007219A MX 2018007219 A MX2018007219 A MX 2018007219A MX 2018007219 A MX2018007219 A MX 2018007219A MX 2018007219 A MX2018007219 A MX 2018007219A MX 2018007219 A MX2018007219 A MX 2018007219A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- methods
- benzodioxol
- compounds
- heterociclic compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 title 1
- -1 1,3-benzodioxole heterocyclic compounds Chemical class 0.000 abstract 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se relaciona con métodos novedosos para la preparación de compuestos heterocíclicos de 1,3-benzodioxol e intermedios para estos. Los compuestos son útiles como inhibidores de PDE4.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15201053 | 2015-12-18 | ||
| PCT/EP2016/081368 WO2017103058A1 (en) | 2015-12-18 | 2016-12-16 | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018007219A true MX2018007219A (es) | 2018-08-01 |
| MX385592B MX385592B (es) | 2025-03-18 |
Family
ID=54850367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018007219A MX385592B (es) | 2015-12-18 | 2016-12-16 | Metodos para preparacion de compuestos heterociclicos de 1,3-benzodioxol. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11370799B2 (es) |
| EP (1) | EP3390407B1 (es) |
| JP (1) | JP6934872B2 (es) |
| KR (1) | KR20180095888A (es) |
| CN (2) | CN108368126B (es) |
| AU (1) | AU2016369371C1 (es) |
| CA (1) | CA3007432A1 (es) |
| DK (1) | DK3390407T3 (es) |
| ES (1) | ES2961237T3 (es) |
| IL (1) | IL259617B (es) |
| MX (1) | MX385592B (es) |
| NZ (1) | NZ742952A (es) |
| PL (1) | PL3390407T3 (es) |
| PT (1) | PT3390407T (es) |
| RU (1) | RU2761337C2 (es) |
| TW (1) | TWI732808B (es) |
| WO (1) | WO2017103058A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2702451T3 (es) * | 2014-06-23 | 2019-03-01 | Leo Pharma As | Métodos para la preparación de compuestos heterocíclicos de 1,3-benzodioxol |
| NZ742952A (en) | 2015-12-18 | 2025-02-28 | Union Therapeutics As | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
| WO2018234299A1 (en) * | 2017-06-20 | 2018-12-27 | Leo Pharma A/S | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
| CN111727191B (zh) | 2017-12-15 | 2024-01-05 | 联合疗法公司 | 取代的氮杂环丁烷二氢噻吩并吡啶类化合物及其作为磷酸二酯酶抑制剂的用途 |
| WO2020148271A1 (en) | 2019-01-15 | 2020-07-23 | UNION therapeutics A/S | Modified release tablet formulations containing phosphodiesterase inhibitors |
| WO2022200339A1 (en) | 2021-03-22 | 2022-09-29 | UNION therapeutics A/S | Treatment of hidradenitis suppurativa with orismilast |
| GB202205715D0 (en) | 2022-04-19 | 2022-06-01 | Union Therapeutics As | Treatment of neutrophilic dermatoses |
| GB202306662D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Dosage regimen |
| GB202306663D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Combination therapy |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514996B2 (en) | 1995-05-19 | 2003-02-04 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of benzofuran or benzodioxole |
| DE10205274A1 (de) | 2002-02-08 | 2003-08-21 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen enthaltend neben Anticholinergika heterocyclische Verbindungen |
| WO2004005276A1 (ja) | 2002-07-03 | 2004-01-15 | Kyowa Hakko Kogyo Co., Ltd. | １，３−ベンゾジオキソール−２−スピロシクロアルカン誘導体の製造法 |
| JP2006008522A (ja) | 2004-06-22 | 2006-01-12 | Sumitomo Chemical Co Ltd | ２，３−ジヒドロキシ−４−アルコキシ−アシルベンゼン類の製造方法 |
| DE602007012105D1 (de) | 2006-07-14 | 2011-03-03 | Chiesi Farma Spa | Derivate von 1-phenyl-2-pyridinylalkylenalkohole als phosphodiesteraseinhibitoren |
| HRP20110464T1 (hr) | 2006-12-22 | 2011-07-31 | Leo Pharma A/S | Supstituirani acetofenoni korisni kao inhibitori pde4 |
| SI2114951T1 (sl) * | 2007-02-28 | 2014-08-29 | Leo Pharma A/S | Novi zaviralci fosfodiesteraze |
| CN101631792B (zh) * | 2007-02-28 | 2013-05-01 | 利奥制药有限公司 | 新的磷酸二酯酶抑制剂 |
| SI2585469T1 (sl) | 2010-06-24 | 2016-11-30 | Leo Pharma A/S | Heterociklične spojine benzodioksola ali benzodioksepina kot zaviralci fostodiesteraze |
| JP2012229192A (ja) | 2011-04-13 | 2012-11-22 | Jsr Corp | （ポリ）イソシアヌレート化合物の製造方法 |
| WO2014096018A1 (en) * | 2012-12-19 | 2014-06-26 | Leo Pharma A/S | Methods for the preparation of substituted acetophenones |
| ES2702451T3 (es) | 2014-06-23 | 2019-03-01 | Leo Pharma As | Métodos para la preparación de compuestos heterocíclicos de 1,3-benzodioxol |
| NZ742952A (en) | 2015-12-18 | 2025-02-28 | Union Therapeutics As | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
| WO2018234299A1 (en) | 2017-06-20 | 2018-12-27 | Leo Pharma A/S | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
-
2016
- 2016-12-16 NZ NZ742952A patent/NZ742952A/en unknown
- 2016-12-16 CN CN201680073306.7A patent/CN108368126B/zh active Active
- 2016-12-16 KR KR1020187020400A patent/KR20180095888A/ko not_active Ceased
- 2016-12-16 PT PT168166536T patent/PT3390407T/pt unknown
- 2016-12-16 WO PCT/EP2016/081368 patent/WO2017103058A1/en not_active Ceased
- 2016-12-16 PL PL16816653.6T patent/PL3390407T3/pl unknown
- 2016-12-16 CN CN202111110500.7A patent/CN114085234B/zh active Active
- 2016-12-16 TW TW105141706A patent/TWI732808B/zh active
- 2016-12-16 AU AU2016369371A patent/AU2016369371C1/en not_active Ceased
- 2016-12-16 DK DK16816653.6T patent/DK3390407T3/da active
- 2016-12-16 MX MX2018007219A patent/MX385592B/es unknown
- 2016-12-16 EP EP16816653.6A patent/EP3390407B1/en active Active
- 2016-12-16 US US16/062,760 patent/US11370799B2/en active Active
- 2016-12-16 JP JP2018531584A patent/JP6934872B2/ja active Active
- 2016-12-16 RU RU2018126363A patent/RU2761337C2/ru active
- 2016-12-16 CA CA3007432A patent/CA3007432A1/en active Pending
- 2016-12-16 ES ES16816653T patent/ES2961237T3/es active Active
-
2018
- 2018-05-27 IL IL259617A patent/IL259617B/en active IP Right Grant
-
2022
- 2022-05-23 US US17/664,483 patent/US20230073362A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016369371A1 (en) | 2018-06-21 |
| BR112018011589A2 (en) | 2018-11-27 |
| US11370799B2 (en) | 2022-06-28 |
| CA3007432A1 (en) | 2017-06-22 |
| HK1258964A1 (zh) | 2019-11-22 |
| RU2018126363A (ru) | 2020-01-22 |
| EP3390407B1 (en) | 2023-10-11 |
| ES2961237T3 (es) | 2024-03-11 |
| TW201725208A (zh) | 2017-07-16 |
| CN108368126B (zh) | 2021-10-08 |
| KR20180095888A (ko) | 2018-08-28 |
| AU2016369371B2 (en) | 2020-12-24 |
| CN108368126A (zh) | 2018-08-03 |
| EP3390407A1 (en) | 2018-10-24 |
| CN114085234A (zh) | 2022-02-25 |
| IL259617B (en) | 2021-05-31 |
| US20200262842A1 (en) | 2020-08-20 |
| RU2761337C2 (ru) | 2021-12-07 |
| RU2018126363A3 (es) | 2020-03-26 |
| NZ742952A (en) | 2025-02-28 |
| JP2018537510A (ja) | 2018-12-20 |
| AU2016369371C1 (en) | 2021-05-13 |
| WO2017103058A1 (en) | 2017-06-22 |
| PL3390407T3 (pl) | 2024-01-29 |
| PT3390407T (pt) | 2023-11-03 |
| IL259617A (en) | 2018-07-31 |
| JP6934872B2 (ja) | 2021-09-15 |
| MX385592B (es) | 2025-03-18 |
| CN114085234B (zh) | 2024-12-17 |
| TWI732808B (zh) | 2021-07-11 |
| DK3390407T3 (da) | 2023-11-06 |
| US20230073362A1 (en) | 2023-03-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2018007219A (es) | Metodos para preparacion de compuestos heterociclicos de 1,3-benzodioxol. | |
| CU20180001A7 (es) | Derivados de oxopiridina sustituidos y procesos para su preparación | |
| PH12018500718A1 (en) | Compounds useful as modulators of trpm8 | |
| CR20190566A (es) | Inhibidores de quinasay usos de los mismos | |
| EA201792535A1 (ru) | Гетероциклические амиды в качестве ингибиторов киназ | |
| EA201891211A1 (ru) | Ингибиторы cxcr2 | |
| EA201890373A1 (ru) | Пиридиновые соединения, пригодные для борьбы с фитопатогенными грибами | |
| EA201591728A1 (ru) | Гетероциклические соединения и способы их применения | |
| EA201692193A1 (ru) | Способы получения ингибитора jak1 и его новых форм | |
| EA201890749A1 (ru) | ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ (ACC) И ИХ ПРИМЕНЕНИЕ | |
| PH12018500408A1 (en) | Bicyclic compounds as atx inhibitors | |
| EA201692219A1 (ru) | Способы получения противовирусных соединений | |
| MX377277B (es) | Derivados de fenoximetilo. | |
| UA116920C2 (uk) | Інгібітори fgfr4 | |
| MX2018001890A (es) | Compuestos biciclicos como inhibidores de autotaxina (atx). | |
| UA113062C2 (xx) | Похідні 5-фтор-4-іміно-3-(заміщеного)-3,4-дигідропіримідин-2(1h)ону | |
| EA201591889A1 (ru) | 6-(5-гидрокси-1h-пиразол-1-ил)никотинамидные ингибиторы phd | |
| EA201790395A1 (ru) | Производные аминотриазина, подходящие для применения в качестве соединений-ингибиторов tank-связывающей киназы | |
| EA201792021A1 (ru) | Ингибитор jak | |
| MX2016015565A (es) | Ciertos inhibidores de la proteina quinasa. | |
| EA202091397A1 (ru) | Бензохинолоновые ингибиторы vmat2 | |
| TW201613934A (en) | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds | |
| MX2017015034A (es) | Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca). | |
| MX373320B (es) | Compuestos inhibidores de pde2. | |
| LT3288944T (lt) | Imidazopirazinonai, kaip pde1 inhibitoriai |