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MX2018004614A - Metodos para preparar celulas t para terapia de celulas t. - Google Patents

Metodos para preparar celulas t para terapia de celulas t.

Info

Publication number
MX2018004614A
MX2018004614A MX2018004614A MX2018004614A MX2018004614A MX 2018004614 A MX2018004614 A MX 2018004614A MX 2018004614 A MX2018004614 A MX 2018004614A MX 2018004614 A MX2018004614 A MX 2018004614A MX 2018004614 A MX2018004614 A MX 2018004614A
Authority
MX
Mexico
Prior art keywords
cells
cell therapy
methods
preparing
differentiation
Prior art date
Application number
MX2018004614A
Other languages
English (en)
Inventor
A Rosenberg Steven
P Restifo Nicholas
Sabatino Marianna
Perez Arianne
Original Assignee
Kite Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kite Pharma Inc filed Critical Kite Pharma Inc
Publication of MX2018004614A publication Critical patent/MX2018004614A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4268—MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46—Viral antigens
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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Abstract

En la presente se proporcionan métodos para retrasar o inhibir la maduración o diferenciación in vitro de células T para una terapia de células T, que comprende poner en contacto una o más células T de un sujeto en necesidad de terapia de células T con un inhibidor de AKT y al menos una de interleucina-7 (IL-7) exógena e interleucina-15 (IL-15) exógena, en donde las células T resultantes exhiben maduración o diferenciación retrasada. En algunas modalidades, el método comprende además administrar la una o más células T a un sujeto en necesidad de una terapia de células T.
MX2018004614A 2015-10-20 2016-10-20 Metodos para preparar celulas t para terapia de celulas t. MX2018004614A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562244036P 2015-10-20 2015-10-20
PCT/US2016/057983 WO2017070395A1 (en) 2015-10-20 2016-10-20 Methods of preparing t cells for t cell therapy

Publications (1)

Publication Number Publication Date
MX2018004614A true MX2018004614A (es) 2019-07-04

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MX2018004614A MX2018004614A (es) 2015-10-20 2016-10-20 Metodos para preparar celulas t para terapia de celulas t.
MX2022015555A MX2022015555A (es) 2015-10-20 2018-04-13 Metodos para preparar celulas t para terapia de celulas t.

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US (4) US20170136063A1 (es)
EP (2) EP3364969A4 (es)
JP (4) JP6952029B2 (es)
KR (3) KR20180063320A (es)
CN (2) CN108366995A (es)
AU (3) AU2016341966A1 (es)
BR (1) BR112018007864A2 (es)
CA (1) CA3001613C (es)
EA (1) EA201890996A1 (es)
HK (1) HK1255319A1 (es)
IL (4) IL292504B2 (es)
MX (2) MX2018004614A (es)
SG (1) SG11201802966TA (es)
TW (4) TW202521141A (es)
WO (1) WO2017070395A1 (es)

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