[go: up one dir, main page]

MX2018004642A - Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía. - Google Patents

Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía.

Info

Publication number
MX2018004642A
MX2018004642A MX2018004642A MX2018004642A MX2018004642A MX 2018004642 A MX2018004642 A MX 2018004642A MX 2018004642 A MX2018004642 A MX 2018004642A MX 2018004642 A MX2018004642 A MX 2018004642A MX 2018004642 A MX2018004642 A MX 2018004642A
Authority
MX
Mexico
Prior art keywords
trajectory
fermentation
genetic engineering
buk
ptb
Prior art date
Application number
MX2018004642A
Other languages
English (en)
Other versions
MX391661B (es
Inventor
Bruce Yarnton Haycock Behrendorff James
Paul Mueller Alexander
Kopke Michael
Edward Hill Ryan
Overgaard Jensen Rasmus
Juminaga Darmawi
Original Assignee
Lanzatech New Zealand Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lanzatech New Zealand Ltd filed Critical Lanzatech New Zealand Ltd
Publication of MX2018004642A publication Critical patent/MX2018004642A/es
Publication of MX391661B publication Critical patent/MX391661B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C12P7/28—Acetone-containing products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01002—Alcohol dehydrogenase (NADP+) (1.1.1.2), i.e. aldehyde reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/07—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with an iron-sulfur protein as acceptor (1.2.7)
    • C12Y102/07005—Aldehyde ferredoxin oxidoreductase (1.2.7.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01008—Phosphate acetyltransferase (2.3.1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01009—Acetyl-CoA C-acetyltransferase (2.3.1.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01019—Phosphate butyryltransferase (2.3.1.19)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02001—Acetate kinase (2.7.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02007—Butyrate kinase (2.7.2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/0202—Acyl-CoA hydrolase (3.1.2.20)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se refiere a una bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía y métodos relacionados a esta. En particular, la invención proporciona una bacteria que comprende una fosfato butiriltransferasa (Ptb) y una butirato cinasa (Buk) (Ptb-Buk) que actúa en sustratos no nativos para producir una amplia variedad de productos e intermediarios. En ciertas modalidades, la invención se refiere a la introducción de Ptb-Buk en un microorganismo que se fija a C1 capaz de producir productos a partir de un sustrato gaseoso.
MX2018004642A 2015-10-13 2016-10-13 Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía MX391661B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562240850P 2015-10-13 2015-10-13
PCT/US2016/056926 WO2017066498A1 (en) 2015-10-13 2016-10-13 Genetically engineered bacterium comprising energy-generating fermentation pathway

Publications (2)

Publication Number Publication Date
MX2018004642A true MX2018004642A (es) 2019-04-15
MX391661B MX391661B (es) 2025-03-21

Family

ID=58499646

Family Applications (4)

Application Number Title Priority Date Filing Date
MX2018004642A MX391661B (es) 2015-10-13 2016-10-13 Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía
MX2023003058A MX2023003058A (es) 2015-10-13 2016-10-13 Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía.
MX2022003568A MX2022003568A (es) 2015-10-13 2016-10-13 Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía.
MX2021003330A MX2021003330A (es) 2015-10-13 2018-04-13 Bacteria dise?ada por ingenieria genetica que comprende una trayectoria de fermentacion que genera energia.

Family Applications After (3)

Application Number Title Priority Date Filing Date
MX2023003058A MX2023003058A (es) 2015-10-13 2016-10-13 Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía.
MX2022003568A MX2022003568A (es) 2015-10-13 2016-10-13 Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía.
MX2021003330A MX2021003330A (es) 2015-10-13 2018-04-13 Bacteria dise?ada por ingenieria genetica que comprende una trayectoria de fermentacion que genera energia.

Country Status (12)

Country Link
US (3) US9738875B2 (es)
EP (2) EP3901267A1 (es)
JP (2) JP6905518B2 (es)
KR (2) KR20180056785A (es)
CN (2) CN113322220A (es)
AU (2) AU2016339989B2 (es)
CA (6) CA3151149C (es)
EA (2) EA202190729A1 (es)
MX (4) MX391661B (es)
MY (5) MY205862A (es)
WO (1) WO2017066498A1 (es)
ZA (5) ZA201802346B (es)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130323820A1 (en) 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
WO2016042012A1 (en) * 2014-09-17 2016-03-24 Global Bioenergies Methods for producing 3-hydroxy-3-methylbutyric acid
WO2016210384A2 (en) 2015-06-25 2016-12-29 Synlogic, Inc. Bacteria engineered to treat metabolic diseases
MX391661B (es) * 2015-10-13 2025-03-21 Lanzatech Nz Inc Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía
GB201603915D0 (en) * 2016-03-07 2016-04-20 Chain Biotechnology Ltd Method and microbes for the production of chiral compounds
CN109477063A (zh) 2016-05-14 2019-03-15 朗泽科技有限公司 具有改变的醛：铁氧还蛋白氧化还原酶活性的微生物和相关方法
WO2018098349A1 (en) 2016-11-22 2018-05-31 The Penn State Research Foundation Devices and methods for generating electrical current from methane
CN107177609B (zh) * 2017-05-15 2020-12-11 大连理工大学 一种fruB基因过表达的重组梭菌、其构建方法及应用
CN107083406B (zh) * 2017-05-27 2021-02-02 浙江华睿生物技术有限公司 (r)-3-羟基丁酸的生产方法
WO2019006255A1 (en) * 2017-06-30 2019-01-03 Invista North America S.A.R.L. METHODS, MATERIALS, SYNTHETIC HOSTS AND REAGENTS FOR HYDROCARBON BIOSYNTHESIS AND DERIVATIVES
CA3074292C (en) 2017-09-08 2021-08-24 Lanzatech, Inc. Processes and systems for metabolite production using hydrogen rich c1-containing substrates
EA202090833A1 (ru) * 2017-09-28 2020-07-16 Ланцатек, Инк. Нокауты в генах микроорганизмов вуда-льюнгдаля
US11505809B2 (en) 2017-09-28 2022-11-22 Inv Nylon Chemicals Americas Llc Organisms and biosynthetic processes for hydrocarbon synthesis
WO2019107516A1 (ja) * 2017-11-30 2019-06-06 東レ株式会社 ３－ヒドロキシアジピン酸、α－ヒドロムコン酸および／またはアジピン酸を生産するための遺伝子改変微生物および当該化学品の製造方法
US11555209B2 (en) 2017-12-19 2023-01-17 Lanzatech, Inc. Microorganisms and methods for the biological production of ethylene glycol
EP3743520A4 (en) * 2018-01-23 2021-11-10 Lanzatech, Inc. TWO-STAGE FERMENTATION PROCESS FOR MANUFACTURING A PRODUCT
US11661613B2 (en) 2018-02-01 2023-05-30 Inv Nylon Chemicals Americas, Llc Methods and materials for the biosynthesis of hydroxy fatty acid anions and/or derivatives thereof and/or compounds related thereto
MY202145A (en) 2018-02-12 2024-04-05 Lanzatech Inc Process for improving carbon conversion efficiency
JP2021520814A (ja) 2018-04-20 2021-08-26 ランザテク，インコーポレイテッド 断続的な電解流
CN109251940B (zh) * 2018-10-30 2020-10-16 浙江华睿生物技术有限公司 一种产β-羟基-β-甲基丁酸工程菌的构建方法
CN112955558A (zh) 2018-11-19 2021-06-11 朗泽科技有限公司 发酵和气化的集成
CN112969795A (zh) 2019-02-08 2021-06-15 朗泽科技有限公司 用于回收沸点接近的产物的方法
CA3127429A1 (en) 2019-03-20 2020-09-24 Global Bioenergies Improved means and methods for producing isobutene from acetyl-coa
FR3096373B1 (fr) 2019-05-24 2024-09-13 Ifp Energies Now Outil genetique optimisé pour modifier les bacteries
CN112955560A (zh) 2019-07-11 2021-06-11 朗泽科技有限公司 优化气体利用的方法
WO2021011763A1 (en) * 2019-07-16 2021-01-21 San Diego State University (SDSU) Foundation, dba San Diego State University Research Foundation Products of manufacture and methods for methane capturing using biofiltration
CN112280722B (zh) * 2019-07-23 2022-03-08 清华大学 用于生产光学纯1,3-丁二醇的重组菌及其应用
CN112280723B (zh) * 2019-07-23 2022-08-19 清华大学 联产1,3-丙二醇和1,3-丁二醇的重组菌及其应用
JP7376041B2 (ja) * 2019-09-11 2023-11-08 公益財団法人地球環境産業技術研究機構 形質転換体及びそれを用いる１，３－ブタンジオールの製造方法
CN111089914A (zh) * 2019-11-07 2020-05-01 河北首朗新能源科技有限公司 微生物发酵生产乙醇中代谢物的高效液相检测方法
US20230044934A1 (en) * 2019-12-23 2023-02-09 Co2Bioclean Gmbh Novel bioplastics
JP7475598B2 (ja) * 2020-03-04 2024-04-30 大阪瓦斯株式会社 １，３－ブタンジオールの製造方法
US11932818B2 (en) 2020-03-16 2024-03-19 Lanzatech, Inc. Tail gas of gas fermentation to dry gasification feedstock
BR112022018609A2 (pt) 2020-03-18 2022-11-08 Lanzatech Inc Microrganismo capaz de produzir 2-feniletanol, e, método de produção de 2-feniletanol
CN111220762A (zh) * 2020-03-24 2020-06-02 河北首朗新能源科技有限公司 一种乙醇梭菌蛋白中有机物的含量的检测方法及应用
WO2021222265A1 (en) * 2020-04-29 2021-11-04 Lanzatech, Inc. FERMENTATIVE PRODUCTION OF β-KETOADIPATE FROM GASEOUS SUBSTRATES
MY197253A (en) * 2020-06-06 2023-06-08 Lanzatech Inc Microorganism with knock-in at acetolactate decarboxylase gene locus
EP4217501A4 (en) * 2020-09-25 2025-03-19 Lanzatech, Inc. Recombinant microorganisms and uses therefor
KR102443037B1 (ko) 2020-10-23 2022-09-14 한국과학기술연구원 에탄올을 포함하는 합성 가스로부터 2,3-부탄디올 제조용 배지 조성물 및 이를 이용한 2,3-부탄디올 생산 방법
EP4208554A4 (en) 2021-02-08 2024-03-20 Lanzatech, Inc. RECOMBINANT MICROORGANISMS AND THEIR USES
JP7645685B2 (ja) * 2021-03-31 2025-03-14 大阪瓦斯株式会社 ２－ヒドロキシイソ酪酸産生能を有する微生物及び２－ヒドロキシイソ酪酸の製造方法
CA3213232A1 (en) 2021-04-09 2022-10-13 Robert John CONRADO Process and apparatus for providing a feedstock
CN115369048B (zh) * 2021-05-17 2023-10-20 华东理工大学 一种产玉米黄质的解脂耶氏酵母基因工程菌及其构建方法和应用
US12241105B2 (en) 2021-07-20 2025-03-04 Lanzatech, Inc. Recombinant microorganisms and uses therefor
TW202307202A (zh) 2021-08-06 2023-02-16 美商朗澤科技有限公司 用於改良乙二醇之生物產生的微生物及方法
US12091648B2 (en) 2021-11-03 2024-09-17 Lanzatech, Inc. System and method for generating bubbles in a vessel
CN116376856B (zh) * 2022-04-06 2023-11-03 深圳蓝晶生物科技有限公司 表达乙酰乙酰辅酶a还原酶变体的工程化微生物及提高pha产量的方法
US11913056B2 (en) 2022-04-06 2024-02-27 Shenzhen Bluepha Biosciences Co., Ltd. Engineered microorganisms expressing acetoacetyl-CoA reductase variants and method for improving the yield of PHA
US12280331B2 (en) 2022-04-29 2025-04-22 Lanzatech, Inc. Low residence time gas separator
US12077800B2 (en) 2022-06-16 2024-09-03 Lanzatech, Inc. Liquid distributor system and process of liquid distribution
JP2025525373A (ja) 2022-06-21 2025-08-05 ランザテク，インコーポレイテッド Ｃ１－基質からのタンデムリピートタンパク質及び化学産物の連続共産生のための微生物及び方法
AU2023289395A1 (en) 2022-06-21 2025-01-09 Lanzatech, Inc. Microorganisms and methods for the continuous co-production of high-value, specialized proteins and chemical products from c1-substrates
US12129503B2 (en) 2022-08-10 2024-10-29 Lanzatech, Inc. Carbon sequestration in soils with production of chemical products
WO2024253883A1 (en) 2023-06-05 2024-12-12 Lanzatech, Inc. Integrated gas fermentation and carbon black processes
US12281344B2 (en) 2023-06-05 2025-04-22 Lanzatech, Inc. Integrated gas fermentation

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593886A (en) 1992-10-30 1997-01-14 Gaddy; James L. Clostridium stain which produces acetic acid from waste gases
UA72220C2 (uk) 1998-09-08 2005-02-15 Байоенджініерінг Рісорсиз, Інк. Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання
CN1217001C (zh) * 2002-01-04 2005-08-31 清华大学 一种生产d－(－)－3－羟基丁酸的方法
ZA200802682B (en) * 2005-09-29 2009-09-30 Du Pont Fermentive production of four carbon alcohols
NZ546496A (en) 2006-04-07 2008-09-26 Lanzatech New Zealand Ltd Gas treatment process
US7704723B2 (en) 2006-08-31 2010-04-27 The Board Of Regents For Oklahoma State University Isolation and characterization of novel clostridial species
NZ553984A (en) 2007-03-19 2009-07-31 Lanzatech New Zealand Ltd Alcohol production process
KR101114918B1 (ko) * 2007-08-09 2012-02-15 주식회사 엘지화학 재조합 미생물을 이용한 광학활성（ｓ）-3-하이드록시부탄산 및（ｓ）-3-하이드록시부티레이트 에스테르의 제조방법
KR101042242B1 (ko) * 2007-09-07 2011-06-17 한국과학기술원 1,4-부탄디올 생성능을 가지는 변이체 및 이를 이용한1,4-부탄디올의 제조방법
EP2217696B1 (en) 2007-11-13 2015-09-16 Lanzatech New Zealand Limited Novel bacteria and methods of use thereof
CN113430119A (zh) * 2008-03-27 2021-09-24 基因组股份公司 用于产生己二酸和其他化合物的微生物
PT2307556T (pt) 2008-06-09 2020-10-23 Lanzatech New Zealand Ltd Produção de butanodiol mediante fermentação microbiana anaeróbia
CN102083990B (zh) 2008-07-04 2016-05-04 财富科学家股份有限公司 通过3-羟基烷酸的酶促脱羧制备烯
WO2010022763A1 (en) * 2008-08-25 2010-03-04 Metabolic Explorer Method for the preparation of 2-hydroxy-isobutyrate
KR20110122672A (ko) * 2008-12-30 2011-11-10 다니스코 유에스 인크. 이소프렌 및 공-산물을 제조하는 방법
SG179048A1 (en) * 2009-09-09 2012-04-27 Genomatica Inc Microorganisms and methods for the co-production of isopropanol with primary alcohols, diols and acids
EP2295593A1 (en) 2009-09-15 2011-03-16 Philippe Marliere Method for the enymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-CoA
SG181607A1 (en) * 2009-12-10 2012-07-30 Genomatica Inc Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol
EP2336341A1 (en) 2009-12-21 2011-06-22 Philippe Marliere Method for producing an alkene comprising the step of converting an alcohol by an enzymatic dehydration step
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US20120040421A1 (en) 2010-03-10 2012-02-16 Lanza Tech New Zealand Limited Acid production by fermentation
WO2012024522A2 (en) 2010-08-19 2012-02-23 Lanzatech New Zealand Limited A process for producing chemicals using microbial fermentation of substrates comprising carbon monoxide
US20130157322A1 (en) 2010-08-26 2013-06-20 Lanzatech New Zealand Limited Process for producing ethanol and ethylene via fermentation
US20110236941A1 (en) * 2010-10-22 2011-09-29 Lanzatech New Zealand Limited Recombinant microorganism and methods of production thereof
US8271519B2 (en) 2010-11-01 2012-09-18 Sas Institute Inc. Systems and methods for fast remote data access from a spreadsheet
US9365868B2 (en) 2011-02-25 2016-06-14 Lanzatech New Zealand Limited Fermentation process for producing isopropanol using a recombinant microorganism
DK2678432T3 (en) 2011-02-25 2018-11-26 Lanzatech New Zealand Ltd RECOMBINANT MICROORGANISMS AND APPLICATIONS THEREOF
EP2753700B1 (en) 2011-09-08 2020-02-19 Lanzatech New Zealand Limited A fermentation process
CN104395455B (zh) 2012-01-31 2020-05-19 朗泽科技新西兰有限公司 重组微生物及其使用方法
EP2855690B1 (en) 2012-05-30 2018-07-11 Lanzatech New Zealand Limited Recombinant microorganisms and their uses
US20130323820A1 (en) * 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
CN104919037A (zh) 2012-06-08 2015-09-16 朗泽科技新西兰有限公司 重组微生物和其用途
US9347076B2 (en) 2012-06-21 2016-05-24 Lanzatech New Zealand Limited Recombinant microorganisms that make biodiesel
CN105051179B (zh) 2012-08-28 2018-06-15 朗泽科技新西兰有限公司 重组微生物和其用途
US8787096B1 (en) 2013-01-16 2014-07-22 Qualcomm Incorporated N-well switching circuit
EP2813575A1 (de) * 2013-06-14 2014-12-17 Evonik Industries AG Verfahren zur Herstellung von organischen Verbindungen aus Knallgas und CO2 über Acetoacetyl-CoA als Zwischenprodukt
SI3077501T1 (sl) * 2013-12-03 2022-02-28 Genomatica, Inc. Mikroorganizmi in metode za izboljšanje donosa izdelkov z uporabo sinteze acetil-coa
WO2015085015A1 (en) 2013-12-03 2015-06-11 Lanzatech New Zealand Limited Microorganisms and methods for the production of ketones
CA2932236A1 (en) 2013-12-31 2015-07-09 Global Bioenergies 3-hydroxyisovalerate (hiv) synthase variants
CN107075464A (zh) 2014-09-03 2017-08-18 环球生物能源公司 从乙酰‑coa产生烯烃的重组微生物
MX391661B (es) * 2015-10-13 2025-03-21 Lanzatech Nz Inc Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía

Also Published As

Publication number Publication date
US20180105847A1 (en) 2018-04-19
MX391661B (es) 2025-03-21
US9738875B2 (en) 2017-08-22
CA3051235A1 (en) 2017-04-20
US20170101631A1 (en) 2017-04-13
MY205861A (en) 2024-11-16
EP3362567A1 (en) 2018-08-22
MY194651A (en) 2022-12-09
CA3151149A1 (en) 2017-04-20
EP3362567A4 (en) 2019-03-27
KR20210037002A (ko) 2021-04-05
MX2022003568A (es) 2023-06-13
JP6905518B2 (ja) 2021-07-21
AU2016339989A1 (en) 2018-05-10
CN108884467A (zh) 2018-11-23
AU2021203008B2 (en) 2024-01-11
CN113322220A (zh) 2021-08-31
MX2023003058A (es) 2023-04-05
US9957531B1 (en) 2018-05-01
MY200202A (en) 2023-12-13
EA201890952A1 (ru) 2018-09-28
MY205862A (en) 2024-11-17
ZA201904454B (en) 2022-09-28
BR112018007338A2 (pt) 2018-10-23
ZA201802346B (en) 2019-12-18
EA202190729A1 (ru) 2022-01-31
ZA201904455B (en) 2021-01-27
JP2018530342A (ja) 2018-10-18
CA3001596C (en) 2019-09-17
CA3151146C (en) 2024-03-19
ZA202102053B (en) 2024-06-26
CA3051235C (en) 2022-05-03
CA3001596A1 (en) 2017-04-20
CA3051234A1 (en) 2017-04-20
CA3151120A1 (en) 2017-04-20
AU2021203008A1 (en) 2021-06-10
CA3151149C (en) 2024-03-26
CA3151146A1 (en) 2017-04-20
CA3051234C (en) 2020-09-15
US20180208952A1 (en) 2018-07-26
MX2021003330A (es) 2021-05-14
WO2017066498A1 (en) 2017-04-20
AU2021203008B9 (en) 2024-01-25
MY205860A (en) 2024-11-16
KR20180056785A (ko) 2018-05-29
JP2021166530A (ja) 2021-10-21
AU2016339989B2 (en) 2022-11-17
ZA202100646B (en) 2022-08-31
EP3901267A1 (en) 2021-10-27
US10316337B2 (en) 2019-06-11

Similar Documents

Publication Publication Date Title
MX2018004642A (es) Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía.
PH12019500281A1 (en) Regulation of gene expression using engineered nucleases
MX2021005226A (es) Regulacion de expresion genica mediada por nucleasa.
ZA201606933B (en) Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
AR105776A1 (es) Recombinación mejorada de loci genómicos
MY192824A (en) Compound targeting il-23a and tnf-alpha and uses thereof
WO2016071505A9 (en) Microbial production of the flavonoids garbanzol, resokaempferol and fisetin
BR112016016539A2 (pt) micro-organismos recombinantes enriquecidos com carboidratos
MY188962A (en) A microorganism of genus corynebacterium having an ability to produce l-arginine and an method for producing l-arginine using the same
MY189896A (en) Microorganisms of the genus corynebacterium having l-isoleucine producing ability and methods for producing l-isoleucine using the same
MX2021007245A (es) Microorganismos para la produccion de putrescina u ornitina y procedimiento para la produccion de putrescina u ornitina usando los mismos.
DK3272860T3 (da) Pyruvatdehydrogenase-mutant, mikroorganisme, der omfatter mutanten, og fremgangsmåde til fremstilling af L-aminosyre ved anvendelse af mikroorganismen
CO2017000367A2 (es) Producción microbiana de dioles grasos
MX2016000634A (es) Metodo optimizado para la ruptura de paredes celulares de chlorella por medio de homogeneizacion a muy alta presion.
MX2018014764A (es) Metodo para producir acido 3-hidroxiadipico.
MY171648A (en) Microorganism producing l-lysine and method for producing l-lysine using the same
MY186338A (en) Method for producing ?-hydromuconic acid
MX2023002009A (es) Sistemas y metodos para controlar una planta de energia.
MX2018014769A (es) Metodo para producir acido a-hidromuconico.
PH12014500175A1 (en) Maize plants having a partially or fully multiplied genome and uses thereof
MY190149A (en) Corynebacterium sp. microorganisms having l-lysine-producing ability and l-lysine producing method using same
MX392300B (es) Elementos reguladores de planta y metodos para usarlos.
BR112017024855A2 (pt) métodos de produção de aldc
UA114997C2 (uk) Рекомбінантний мікроорганізм з роду escherichia, що виробляє l-амінокислоту, та спосіб одержання l-амінокислоти
MX2020006849A (es) Cebada con actividad enzimatica hidrolitica incrementada.