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MX2018004524A - Derivados de eter ciclico de pirazolo[1,5-a]pirimidin-3-carboxiami da. - Google Patents

Derivados de eter ciclico de pirazolo[1,5-a]pirimidin-3-carboxiami da.

Info

Publication number
MX2018004524A
MX2018004524A MX2018004524A MX2018004524A MX2018004524A MX 2018004524 A MX2018004524 A MX 2018004524A MX 2018004524 A MX2018004524 A MX 2018004524A MX 2018004524 A MX2018004524 A MX 2018004524A MX 2018004524 A MX2018004524 A MX 2018004524A
Authority
MX
Mexico
Prior art keywords
pyrazolo
ether derivatives
carboxyam
ide
pyrimidine
Prior art date
Application number
MX2018004524A
Other languages
English (en)
Other versions
MX376458B (es
Inventor
Hoenke Christoph
Frattini Sara
Giovannini Riccardo
Ferrara Marco
Bertani Barbara
FOSSATI Giacomo
Hobson Scott
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2018004524A publication Critical patent/MX2018004524A/es
Publication of MX376458B publication Critical patent/MX376458B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
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    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)

Abstract

La invención se refiere a derivados de éter espirocíclico de pirazolo[1,5-a]pirimidin-3-carboxiamida de la Fórmula general (I) que son inhibidores de la fosfodiesterasa 2, útiles en el tratamiento de enfermedades del sistema nervioso central y otras enfermedades. Además, la invención se refiere a procesos para preparar composiciones farmacéuticas, así como a procesos para la fabricación de compuestos de acuerdo con la invención.
MX2018004524A 2015-10-13 2016-10-12 Derivados de éter cíclico de pirazolo[1,5-a]pirimidin-3-carboxiamida. MX376458B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15189600.8A EP3156405A1 (en) 2015-10-13 2015-10-13 Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
PCT/EP2016/074380 WO2017064082A1 (en) 2015-10-13 2016-10-12 Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide

Publications (2)

Publication Number Publication Date
MX2018004524A true MX2018004524A (es) 2018-06-27
MX376458B MX376458B (es) 2025-03-07

Family

ID=54293164

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018004524A MX376458B (es) 2015-10-13 2016-10-12 Derivados de éter cíclico de pirazolo[1,5-a]pirimidin-3-carboxiamida.

Country Status (30)

Country Link
US (5) US10023575B2 (es)
EP (2) EP3156405A1 (es)
JP (1) JP6626965B2 (es)
KR (1) KR102611558B1 (es)
CN (2) CN114181213B (es)
AU (1) AU2016338602B2 (es)
BR (1) BR112018004347B1 (es)
CA (1) CA3001929C (es)
CL (1) CL2018000856A1 (es)
CO (1) CO2018003756A2 (es)
CY (1) CY1125323T1 (es)
DK (1) DK3362453T3 (es)
EA (1) EA035350B1 (es)
ES (1) ES2912223T3 (es)
HR (1) HRP20220595T1 (es)
IL (1) IL258070B (es)
LT (1) LT3362453T (es)
MA (1) MA42988B1 (es)
MX (1) MX376458B (es)
MY (1) MY195169A (es)
NZ (1) NZ740119A (es)
PE (2) PE20190778A1 (es)
PH (1) PH12018500796B1 (es)
PL (1) PL3362453T3 (es)
PT (1) PT3362453T (es)
RS (1) RS63218B1 (es)
SA (1) SA518391334B1 (es)
SI (1) SI3362453T1 (es)
UA (1) UA124576C2 (es)
WO (1) WO2017064082A1 (es)

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Publication number Priority date Publication date Assignee Title
EP3156405A1 (en) 2015-10-13 2017-04-19 Boehringer Ingelheim International GmbH Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
RU2671964C1 (ru) * 2017-08-30 2018-11-08 Сиа Эволед Пиразоло[1,5-а]пиримидинкарбоксилаты гадолиния и органические светодиоды на их основе
CN112867722B (zh) * 2019-01-18 2022-09-23 苏州亚盛药业有限公司 作为mcl-1抑制剂的大螺环醚(macrocyclic spiroethers)
CN110339197A (zh) * 2019-06-24 2019-10-18 中山大学 一种防治血管性痴呆的磷酸二酯酶9a抑制剂的用途
PH12022550877A1 (en) * 2019-10-16 2023-03-27 Chemocentryx Inc Heteroaryl-biphenyl amines for the treatment of pd-l1 diseases

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Also Published As

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SI3362453T1 (sl) 2022-06-30
IL258070A (en) 2018-05-31
AU2016338602A1 (en) 2018-03-15
HRP20220595T1 (hr) 2022-06-10
EP3362453A1 (en) 2018-08-22
US11691977B2 (en) 2023-07-04
SA518391334B1 (ar) 2021-03-29
UA124576C2 (uk) 2021-10-13
DK3362453T3 (da) 2022-06-07
MA42988B1 (fr) 2022-04-29
CO2018003756A2 (es) 2018-07-10
LT3362453T (lt) 2022-05-25
MX376458B (es) 2025-03-07
PE20181447A1 (es) 2018-09-12
PL3362453T3 (pl) 2022-07-25
CY1125323T1 (el) 2024-12-13
WO2017064082A1 (en) 2017-04-20
EP3156405A1 (en) 2017-04-19
US20210032259A1 (en) 2021-02-04
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US10479794B2 (en) 2019-11-19
US20170101411A1 (en) 2017-04-13
JP2018534279A (ja) 2018-11-22
PH12018500796A1 (en) 2018-10-29
BR112018004347B1 (pt) 2023-12-05
EA035350B1 (ru) 2020-05-29
KR20180063316A (ko) 2018-06-11
CN108137602A (zh) 2018-06-08
PH12018500796B1 (en) 2022-10-26
BR112018004347A2 (pt) 2018-10-09
US10023575B2 (en) 2018-07-17
US12351584B2 (en) 2025-07-08
ES2912223T3 (es) 2022-05-25
EA201890922A1 (ru) 2018-11-30
CN114181213A (zh) 2022-03-15
JP6626965B2 (ja) 2019-12-25
CA3001929A1 (en) 2017-04-20
PE20190778A1 (es) 2019-06-06
PT3362453T (pt) 2022-05-04
CN108137602B (zh) 2021-09-28
US20200039991A1 (en) 2020-02-06
RS63218B1 (sr) 2022-06-30
CN114181213B (zh) 2024-08-30
IL258070B (en) 2020-06-30
MY195169A (en) 2023-01-11
HK1254651A1 (en) 2019-07-26
AU2016338602B2 (en) 2020-07-16
US20180134720A1 (en) 2018-05-17
EP3362453B1 (en) 2022-03-30
CA3001929C (en) 2023-11-28
CL2018000856A1 (es) 2018-07-27
KR102611558B1 (ko) 2023-12-11
US10875867B2 (en) 2020-12-29
US20230286993A1 (en) 2023-09-14
MA42988A (fr) 2021-04-07

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