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MX2018004296A - Combinacion de un agonista selectivo de il-2rbeta y un agonista il-15 de accion prolongada. - Google Patents

Combinacion de un agonista selectivo de il-2rbeta y un agonista il-15 de accion prolongada.

Info

Publication number
MX2018004296A
MX2018004296A MX2018004296A MX2018004296A MX2018004296A MX 2018004296 A MX2018004296 A MX 2018004296A MX 2018004296 A MX2018004296 A MX 2018004296A MX 2018004296 A MX2018004296 A MX 2018004296A MX 2018004296 A MX2018004296 A MX 2018004296A
Authority
MX
Mexico
Prior art keywords
acting
long
agonist
2rbeta
combination
Prior art date
Application number
MX2018004296A
Other languages
English (en)
Inventor
Charych Deborah
Kirk Peter
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of MX2018004296A publication Critical patent/MX2018004296A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2086—IL-13 to IL-16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

En una o más realizaciones de la invención, se proporciona un método, comprendiendo el método las etapas de administrar a un paciente con cáncer: (a) una cantidad activante de IL-2Rß de un agonista selectivo de IL-2Rß de acción prolongada; y (b) una cantidad activante de IL-15R de un resto de IL-15 de acción prolongada; en una o más realizaciones de la invención, se proporciona una composición, comprendiendo la composición: una cantidad activante de IL-2Rß de un agonista selectivo de IL-2Rß de acción prolongada y una cantidad activante de IL-15R de un resto de IL-15 de acción prolongada; en una o más realizaciones de la invención, se proporciona un kit, comprendiendo el kit: una cantidad activante de IL-2Rß de un agonista selectivo de IL-2Rß de acción prolongada; una cantidad activante de IL-15R de un resto de IL-15 de acción prolongada; e instrucciones para el uso del agonista selectivo de IL-2Rß y el resto de IL-15 de acción prolongada.
MX2018004296A 2015-10-08 2016-10-07 Combinacion de un agonista selectivo de il-2rbeta y un agonista il-15 de accion prolongada. MX2018004296A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562239207P 2015-10-08 2015-10-08
PCT/US2016/056088 WO2017062832A1 (en) 2015-10-08 2016-10-07 Combination of an il-2rbeta-selective agonist and a long-acting il-15 agonist

Publications (1)

Publication Number Publication Date
MX2018004296A true MX2018004296A (es) 2018-08-01

Family

ID=57249859

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018004296A MX2018004296A (es) 2015-10-08 2016-10-07 Combinacion de un agonista selectivo de il-2rbeta y un agonista il-15 de accion prolongada.

Country Status (10)

Country Link
US (1) US12233104B2 (es)
EP (1) EP3359182B1 (es)
JP (3) JP7407511B2 (es)
KR (1) KR102861230B1 (es)
CN (1) CN108135978A (es)
AU (1) AU2016335860B2 (es)
IL (1) IL258456B (es)
MA (1) MA47290A (es)
MX (1) MX2018004296A (es)
WO (1) WO2017062832A1 (es)

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CN111093688B (zh) 2017-05-15 2025-09-16 尼克塔治疗公司 长效白细胞介素-15受体激动剂以及相关免疫治疗组合物和方法
US11248025B2 (en) 2019-06-03 2022-02-15 Medikine, Inc. IL-2alpha receptor subunit binding compounds
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
US20250222027A1 (en) 2022-04-01 2025-07-10 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies

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Also Published As

Publication number Publication date
KR102861230B1 (ko) 2025-09-17
MA47290A (fr) 2019-11-27
EP3359182B1 (en) 2023-04-19
CN108135978A (zh) 2018-06-08
IL258456A (en) 2018-06-28
US12233104B2 (en) 2025-02-25
WO2017062832A1 (en) 2017-04-13
JP2023099731A (ja) 2023-07-13
EP3359182A1 (en) 2018-08-15
IL258456B (en) 2021-07-29
AU2016335860A1 (en) 2018-04-12
JP7407511B2 (ja) 2024-01-04
JP2018530568A (ja) 2018-10-18
KR20180063184A (ko) 2018-06-11
AU2016335860B2 (en) 2023-08-10
US20180296645A1 (en) 2018-10-18
JP2021066748A (ja) 2021-04-30
HK1253347A1 (en) 2019-06-14
CA3000211A1 (en) 2017-04-13

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