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MX2017017124A - 6-amino-quinolin-3-carbonitrilos como moduladores de cancer osaka tiroides (cot). - Google Patents

6-amino-quinolin-3-carbonitrilos como moduladores de cancer osaka tiroides (cot).

Info

Publication number
MX2017017124A
MX2017017124A MX2017017124A MX2017017124A MX2017017124A MX 2017017124 A MX2017017124 A MX 2017017124A MX 2017017124 A MX2017017124 A MX 2017017124A MX 2017017124 A MX2017017124 A MX 2017017124A MX 2017017124 A MX2017017124 A MX 2017017124A
Authority
MX
Mexico
Prior art keywords
carbonitrils
quinoline
amino
cot
modulators
Prior art date
Application number
MX2017017124A
Other languages
English (en)
Inventor
Phillips Gary
O Link John
M Zipfel Sheila
A Kirschberg Thorsten
j watkins William
M Bacon Elizabeth
J Cottell Jeromy
D Schroeder Scott
Chou Chien-Hung
G Taylor James
L Stevens Kirk
Kim Musong
t clark Christopher
E Wright Nathan
Balan Gayatri
H Squires Neil
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MX2017017124A publication Critical patent/MX2017017124A/es

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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

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Abstract

La presente descripción se refiere en términos generales a moduladores de Cot (cáncer Osaka Tiroides) y a métodos de uso y fabricación de los mismos.
MX2017017124A 2015-07-06 2016-06-30 6-amino-quinolin-3-carbonitrilos como moduladores de cancer osaka tiroides (cot). MX2017017124A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562189155P 2015-07-06 2015-07-06
US201562269061P 2015-12-17 2015-12-17
PCT/US2016/040552 WO2017007694A1 (en) 2015-07-06 2016-06-30 6-amino-quinoline-3-carbonitrils as cot modulators

Publications (1)

Publication Number Publication Date
MX2017017124A true MX2017017124A (es) 2018-03-09

Family

ID=56497863

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017017124A MX2017017124A (es) 2015-07-06 2016-06-30 6-amino-quinolin-3-carbonitrilos como moduladores de cancer osaka tiroides (cot).

Country Status (18)

Country Link
US (2) US9815818B2 (es)
EP (1) EP3319955B1 (es)
JP (1) JP6525362B2 (es)
KR (2) KR20200022527A (es)
CN (1) CN108026067B (es)
AU (1) AU2016289817B2 (es)
BR (1) BR112018000187A2 (es)
CA (1) CA2991572A1 (es)
EA (1) EA201792612A1 (es)
ES (1) ES2849953T3 (es)
IL (1) IL256432A (es)
MX (1) MX2017017124A (es)
NZ (1) NZ738538A (es)
PL (1) PL3319955T3 (es)
PT (1) PT3319955T (es)
SI (1) SI3319955T1 (es)
TW (1) TWI711611B (es)
WO (1) WO2017007694A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016057931A1 (en) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
US9815818B2 (en) 2015-07-06 2017-11-14 Gilead Sciences, Inc. Cot modulators and methods of use thereof
EP3456717B1 (en) 2015-07-06 2021-03-17 Gilead Sciences, Inc. 4,6-diamino-quinoline-3-carbonitrile derivative as cancer osaka thyroid (cot) modulator for treating inflammatory disease
EP3478674B1 (en) 2016-06-30 2020-05-13 Gilead Sciences, Inc. 4,6-diaminoquinazolines as cot modulators and methods of use thereof
CN108329306A (zh) * 2017-07-09 2018-07-27 曹艳 一种用于治疗艾滋病药物的制备方法
JPWO2019065516A1 (ja) * 2017-09-26 2020-09-10 日本曹達株式会社 キノリン化合物および農園芸用殺菌剤
TW202235416A (zh) * 2019-06-14 2022-09-16 美商基利科學股份有限公司 Cot 調節劑及其使用方法
EP4126231A1 (en) 2020-03-30 2023-02-08 Gilead Sciences, Inc. Solid forms of (s)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1h-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound
PL4126862T3 (pl) 2020-04-02 2025-09-08 Gilead Sciences, Inc. Sposób wytwarzania związku będącego inhibitorem cot
TW202304435A (zh) 2021-06-04 2023-02-01 美商基利科學股份有限公司 治療ｎａｓｈ之方法
CN115433096B (zh) * 2022-09-16 2024-02-06 浙江省农业科学院 一种抗臭氧剂的制备方法
WO2024245157A1 (zh) * 2023-05-30 2024-12-05 浙江星浩澎博医药有限公司 氮杂喹啉环衍生物

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UA73073C2 (uk) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
SG145744A1 (en) 2003-08-19 2008-09-29 Wyeth Corp Process for the preparation of 4-amino-3- quinolinecarbonitriles
JP2008540656A (ja) * 2005-05-18 2008-11-20 ワイス Ｔｐｌ２キナーゼの３−シアノキノリン阻害物質ならびにそれを製造および使用する方法
EP1881981A1 (en) 2005-05-18 2008-01-30 Wyeth 4, 6-diamino-[1,7] naphthyridine-3-carbonitrile inhibitors of tpl2 kinase and methods of making and using the same
MX2008012482A (es) 2006-03-31 2008-10-10 Abbott Lab Compuestos de indazol.
WO2008055950A1 (en) * 2006-11-09 2008-05-15 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
US20130059851A1 (en) 2010-03-09 2013-03-07 Dana-Farber Cancer Institute, Inc. Methods of Diagnosing and Treating Cancer in Patients Having or Developing Resistance to a First Cancer Therapy
IN2015DN03795A (es) * 2012-10-24 2015-10-02 Inserm Inst Nat De La Santé Et De La Rech Médicale
US9815818B2 (en) 2015-07-06 2017-11-14 Gilead Sciences, Inc. Cot modulators and methods of use thereof
EP3456717B1 (en) 2015-07-06 2021-03-17 Gilead Sciences, Inc. 4,6-diamino-quinoline-3-carbonitrile derivative as cancer osaka thyroid (cot) modulator for treating inflammatory disease
EP3478674B1 (en) 2016-06-30 2020-05-13 Gilead Sciences, Inc. 4,6-diaminoquinazolines as cot modulators and methods of use thereof

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Publication number Publication date
TWI711611B (zh) 2020-12-01
AU2016289817A1 (en) 2018-01-18
PL3319955T3 (pl) 2021-05-04
ES2849953T3 (es) 2021-08-24
EP3319955A1 (en) 2018-05-16
KR20180022981A (ko) 2018-03-06
JP2018520160A (ja) 2018-07-26
SI3319955T1 (sl) 2021-01-29
US9815818B2 (en) 2017-11-14
US20170362201A1 (en) 2017-12-21
AU2016289817B2 (en) 2019-01-31
TW201713643A (zh) 2017-04-16
WO2017007694A1 (en) 2017-01-12
HK1252613A1 (en) 2019-05-31
US20170008873A1 (en) 2017-01-12
KR102082331B1 (ko) 2020-02-27
US10316017B2 (en) 2019-06-11
PT3319955T (pt) 2021-01-05
CA2991572A1 (en) 2017-01-12
EA201792612A1 (ru) 2018-07-31
IL256432A (en) 2018-02-28
CN108026067A (zh) 2018-05-11
KR20200022527A (ko) 2020-03-03
NZ738538A (en) 2019-06-28
EP3319955B1 (en) 2020-11-25
JP6525362B2 (ja) 2019-06-05
CN108026067B (zh) 2021-01-12
BR112018000187A2 (pt) 2018-09-04

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