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MX2018003592A - Sales y formas solidas de un antibiotico de monobactam. - Google Patents

Sales y formas solidas de un antibiotico de monobactam.

Info

Publication number
MX2018003592A
MX2018003592A MX2018003592A MX2018003592A MX2018003592A MX 2018003592 A MX2018003592 A MX 2018003592A MX 2018003592 A MX2018003592 A MX 2018003592A MX 2018003592 A MX2018003592 A MX 2018003592A MX 2018003592 A MX2018003592 A MX 2018003592A
Authority
MX
Mexico
Prior art keywords
salts
solid forms
monobactam
antibiotic
oxo
Prior art date
Application number
MX2018003592A
Other languages
English (en)
Other versions
MX377532B (es
Inventor
Mutz Michael
Lowell Simmons Robert
Casarez Anthony
Ernst Moser Heinz
Reck Folkert
Aubin Eric
Fisch Andreas
Li Zaixing
Lindvall Mika
Ulrich Riebesehl Bernd
Schoenhentz Marc
Sethuraman Vijay
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2018003592A publication Critical patent/MX2018003592A/es
Publication of MX377532B publication Critical patent/MX377532B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La invención proporciona nuevas formas sólidas, sales y polimorfos del ácido 1- (((Z) - (1- (2-aminotiazol-4-il) -2-oxo-2 - (((3S, 4R) -2- ácido oxo-4 - ((2-oxooxazolidin-3-il) metil) -1-sulfoazetidin-3-il) amino) etiliden) amino) oxi) ciclopropanocarboxílico (al que se hace referencia en este documento como Compuesto X), composiciones farmacéuticas que los contienen, y procesos para su fabricación y uso en terapia.
MX2018003592A 2015-09-23 2016-09-20 Sales y formas sólidas de un antibiótico de monobactam. MX377532B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562222430P 2015-09-23 2015-09-23
PCT/CN2016/099482 WO2017050218A1 (en) 2015-09-23 2016-09-20 Salts and solid forms of monobactam antibiotic

Publications (2)

Publication Number Publication Date
MX2018003592A true MX2018003592A (es) 2018-06-18
MX377532B MX377532B (es) 2025-03-10

Family

ID=58385723

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018003592A MX377532B (es) 2015-09-23 2016-09-20 Sales y formas sólidas de un antibiótico de monobactam.

Country Status (26)

Country Link
US (1) US10919887B2 (es)
EP (1) EP3353175B1 (es)
JP (1) JP6837480B2 (es)
KR (1) KR102749337B1 (es)
CN (1) CN108137573B (es)
AU (1) AU2016327264B2 (es)
CA (1) CA2999794C (es)
CL (2) CL2018000745A1 (es)
CY (1) CY1123509T1 (es)
DK (1) DK3353175T3 (es)
EA (2) EA037569B1 (es)
ES (1) ES2817537T3 (es)
HR (1) HRP20201423T1 (es)
HU (1) HUE050849T2 (es)
IL (1) IL258254B (es)
LT (1) LT3353175T (es)
MA (1) MA42946B1 (es)
MX (1) MX377532B (es)
PH (1) PH12018500653B1 (es)
PL (1) PL3353175T3 (es)
PT (1) PT3353175T (es)
RS (1) RS60805B1 (es)
RU (1) RU2754180C2 (es)
SI (1) SI3353175T1 (es)
SM (1) SMT202000480T1 (es)
WO (1) WO2017050218A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3661933B1 (en) 2017-08-02 2022-03-23 Novartis AG Process for preparing 1-(((z)-(1-(2-aminothiazol-4-yl)-2-oxo-2-(((3s,4r)-2-oxo-4-((2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3- yl)amino)ethylidene)amino)oxy)cyclopropane carboxylic acid
CN111032792A (zh) * 2017-08-16 2020-04-17 株式会社Lg化学 包含zif类粉末的白色颜料、聚合物树脂膜和使用白色颜料改变介质的颜色的方法
US20200360349A1 (en) * 2017-11-10 2020-11-19 Novartis Ag Administration of monobactam for the treatment of urinary tract infection
JP7280273B2 (ja) * 2018-01-29 2023-05-23 メッドシャイン ディスカバリー インコーポレイテッド 細菌感染を治療するための単環β－ラクタム化合物
JP7179185B2 (ja) * 2018-12-18 2022-11-28 メッドシャイン ディスカバリー インコーポレイテッド 医薬の製造おける単環式β－ラクタム化合物の使用
KR102786898B1 (ko) * 2019-11-22 2025-03-25 쑤저우 얼예 파마슈티칼 컴퍼니 리미티드 설포닐우레아 고리 치환 모노시클릭 β-락탐계 항생제
CN114828850B (zh) 2019-12-19 2024-08-13 深圳嘉科生物科技有限公司 化合物在制药中的应用
CN113754651B (zh) 2020-06-02 2023-04-18 中国医学科学院医药生物技术研究所 一种β-内酰胺化合物、其用途及其制备方法
CN114728953B (zh) * 2020-08-06 2024-04-09 宁夏农林科学院 β-内酰胺类化合物，及其制备方法以及其作为抗菌素的应用
WO2022185241A1 (en) 2021-03-04 2022-09-09 Bp Asset Vi, Inc. Process for manufacturing a monobactam antibiotic
WO2022185240A1 (en) 2021-03-04 2022-09-09 Bp Asset Vi, Inc. Formulation of a monobactam antibiotic
CN115304594B (zh) * 2022-10-12 2023-02-14 苏州二叶制药有限公司 磺酰脲环取代的化合物的盐型及其晶型

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NZ205240A (en) 1980-02-07 1984-07-31 Squibb & Sons Inc Sulphonamide derivatives,being starting materials for producing beta-lactams
EP0048953B1 (en) 1980-09-29 1988-03-09 E.R. Squibb & Sons, Inc. Beta-lactam antibiotics
US4775670A (en) 1980-09-29 1988-10-04 E. R. Squibb & Sons, Inc. 2-oxo-1-azetidinesulfonic acid salts
WO1982001873A1 (en) 1980-12-05 1982-06-10 Takeda Chemical Industries Ltd 1-sulfo-2-oxoazetidine derivatives and process for their preparation
US4782147A (en) 1980-12-05 1988-11-01 Takeda Chemical Industries, Ltd. 1-sulfo-2-oxoazetidine derivatives and their production
CA1262128A (en) 1981-08-27 1989-10-03 Christian N. Hubschwerlen .beta.-lactams
IL67451A (en) 1981-12-25 1987-10-20 Takeda Chemical Industries Ltd 4-cyano-2-azetidinones and production thereof and process for the preparation of 4-carbamoyl-2-azetidinones using them
AU564150B2 (en) * 1982-04-30 1987-08-06 Takeda Chemical Industries Ltd. 1-sulfo-2-azetidinone derivatives
CA1203806A (en) 1982-05-31 1986-04-29 Susumu Nakagawa 2-oxo-1-azetidinesulfonic acid derivatives, process for production thereof, and use thereof
DE3377061D1 (en) 1982-06-03 1988-07-21 Hoffmann La Roche Process for the preparation of 1-sulfo-2-oxoazetidine derivatives
JPS6153282A (ja) 1984-08-22 1986-03-17 Banyu Pharmaceut Co Ltd 単環β−ラクタム誘導体
JPS6153283A (ja) 1984-08-24 1986-03-17 Banyu Pharmaceut Co Ltd ２−オキソ−１−アゼチジンスルホン酸誘導体
US4610824A (en) 1984-10-09 1986-09-09 E. R. Squibb & Sons, Inc. Hydrazide derivatives of monocyclic beta-lactam antibiotics
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NZ591728A (en) 2008-10-31 2012-12-21 Shionogi & Co Cephalosporin having catechol group
JP2012512863A (ja) * 2008-12-19 2012-06-07 ファイザー・インク モノカルバム
DK2646436T3 (en) 2010-11-29 2015-06-29 Pfizer monobactams
UY34585A (es) 2012-01-24 2013-09-02 Aicuris Gmbh & Co Kg Compuestos b-lactámicos sustituidos con amidina, su preparación y uso
CN103044416A (zh) 2012-12-17 2013-04-17 浙江华方药业有限责任公司 一种卡芦莫南钠的合成方法
WO2015103583A1 (en) 2014-01-06 2015-07-09 President And Fellows Of Harvard College Monobactams and methods of their synthesis and use
TWI714525B (zh) * 2014-03-24 2021-01-01 瑞士商諾華公司 用於治療細菌感染之單內醯胺（ｍｏｎｏｂａｃｔａｍ）有機化合物

Also Published As

Publication number Publication date
EA202092620A1 (ru) 2021-06-30
RU2754180C2 (ru) 2021-08-30
CY1123509T1 (el) 2022-03-24
AU2016327264B2 (en) 2019-06-27
CA2999794C (en) 2023-08-15
MA42946B1 (fr) 2020-10-28
KR20180054816A (ko) 2018-05-24
SMT202000480T1 (it) 2020-11-10
DK3353175T3 (da) 2020-09-14
EP3353175A1 (en) 2018-08-01
HUE050849T2 (hu) 2021-01-28
IL258254B (en) 2021-02-28
US10919887B2 (en) 2021-02-16
JP6837480B2 (ja) 2021-03-03
CN108137573B (zh) 2021-06-11
CA2999794A1 (en) 2017-03-30
LT3353175T (lt) 2020-10-12
WO2017050218A1 (en) 2017-03-30
RS60805B1 (sr) 2020-10-30
IL258254A (en) 2018-05-31
PH12018500653A1 (en) 2018-10-01
HRP20201423T1 (hr) 2020-12-11
PH12018500653B1 (en) 2022-05-04
KR102749337B1 (ko) 2025-01-03
EP3353175A4 (en) 2019-06-26
EP3353175B1 (en) 2020-08-12
ES2817537T3 (es) 2021-04-07
MA42946A (fr) 2018-08-01
JP2018528241A (ja) 2018-09-27
PT3353175T (pt) 2020-09-10
BR112018005805A2 (pt) 2018-10-16
US20180273522A1 (en) 2018-09-27
HK1257271A1 (en) 2019-10-18
RU2018114480A (ru) 2019-10-23
AU2016327264A1 (en) 2018-05-10
CN108137573A (zh) 2018-06-08
EA201890771A1 (ru) 2018-09-28
EA037569B1 (ru) 2021-04-15
PL3353175T3 (pl) 2021-02-22
CL2019003324A1 (es) 2020-04-17
CL2018000745A1 (es) 2018-06-22
SI3353175T1 (sl) 2020-11-30
MX377532B (es) 2025-03-10
RU2018114480A3 (es) 2020-06-09

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