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MX2018001208A - Moleculas con direccion a las celulas que comprenden efectores de la subunidad a de la toxina shiga y epitopos de celulas-t cd8+. - Google Patents

Moleculas con direccion a las celulas que comprenden efectores de la subunidad a de la toxina shiga y epitopos de celulas-t cd8+.

Info

Publication number
MX2018001208A
MX2018001208A MX2018001208A MX2018001208A MX2018001208A MX 2018001208 A MX2018001208 A MX 2018001208A MX 2018001208 A MX2018001208 A MX 2018001208A MX 2018001208 A MX2018001208 A MX 2018001208A MX 2018001208 A MX2018001208 A MX 2018001208A
Authority
MX
Mexico
Prior art keywords
cell
targeting molecules
shiga toxin
immune
epitope
Prior art date
Application number
MX2018001208A
Other languages
English (en)
Inventor
Poma Eric
Willert Erin
kim Jason
Original Assignee
Molecular Templates Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/965,882 external-priority patent/US20160177284A1/en
Application filed by Molecular Templates Inc filed Critical Molecular Templates Inc
Publication of MX2018001208A publication Critical patent/MX2018001208A/es

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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Abstract

La presente invención proporciona moléculas con dirección a las células que pueden suministrar una carga de epítopo de células-T CD8+ a la senda de presentación de MHC clase I de la célula. Las moléculas con dirección a las células de la invención se pueden utilizar para suministrar virtualmente cualquier epítopo de células-T CD8+ desde un espacio extracelular hasta la senda de MHC clase I de una célula objetivo, la cual puede ser una célula maligna y/o una célula no inmunitaria. La célula objetivo entonces puede exhibir, sobre una superficie celular, el epítopo de células-T CD8+ suministrado que forma complejo con la molécula de MHC I. Las moléculas con dirección a las células de la invención tienen usos que incluyen el marcado dirigido y/o la aniquilación de tipos de células específicos dentro de una mezcla de tipos de células, incluyendo dentro de un cordado, así como la estimulación de respuestas inmunitarias benéficas. Las moléculas con dirección a las células de la invención tienen usos, por ejemplo, en el tratamiento de una variedad de enfermedades, trastornos y afecciones, incluyendo cánceres, tumores, anormalidades del crecimiento, trastornos inmunológicos e infecciones microbianas.
MX2018001208A 2015-07-26 2016-07-25 Moleculas con direccion a las celulas que comprenden efectores de la subunidad a de la toxina shiga y epitopos de celulas-t cd8+. MX2018001208A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562197048P 2015-07-26 2015-07-26
US14/965,882 US20160177284A1 (en) 2014-01-27 2015-12-10 Cell-targeted molecules comprising amino-terminus proximal or amino-terminal shiga toxin a subunit effector regions
PCT/US2016/043902 WO2017019623A2 (en) 2015-07-26 2016-07-25 Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes

Publications (1)

Publication Number Publication Date
MX2018001208A true MX2018001208A (es) 2018-03-26

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ID=57885282

Family Applications (1)

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MX2018001208A MX2018001208A (es) 2015-07-26 2016-07-25 Moleculas con direccion a las celulas que comprenden efectores de la subunidad a de la toxina shiga y epitopos de celulas-t cd8+.

Country Status (11)

Country Link
US (1) US20170143814A1 (es)
EP (1) EP3325510A2 (es)
JP (2) JP6884133B2 (es)
KR (1) KR20180030085A (es)
CN (1) CN107922493A (es)
AU (1) AU2016297920A1 (es)
CA (1) CA2991259A1 (es)
HK (1) HK1248258A1 (es)
IL (1) IL256317B (es)
MX (1) MX2018001208A (es)
WO (1) WO2017019623A2 (es)

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